Apelin/APJ system: A novel promising target for neurodegenerative diseases

Luo, Huaiqing; Han, Li; Xu, Jin

doi:10.1002/jcp.29001

Cited by 43 publications

(26 citation statements)

References 236 publications

(321 reference statements)

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“…Moreover, the apelin domain was also significantly enriched by the genes identified from mRNA expression ( p = 1.15 E −2). Apelin has been proposed as a promising target for AD 26 , 27 . Apelin are expressed in various parts of the central nervous system in humans 28 and plays an important role in the pathogenesis of AD 27 .…”

Section: Resultsmentioning

confidence: 99%

MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification

et al. 2021

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To fully utilize the advances in omics technologies and achieve a more comprehensive understanding of human diseases, novel computational methods are required for integrative analysis of multiple types of omics data. Here, we present a novel multi-omics integrative method named Multi-Omics Graph cOnvolutional NETworks (MOGONET) for biomedical classification. MOGONET jointly explores omics-specific learning and cross-omics correlation learning for effective multi-omics data classification. We demonstrate that MOGONET outperforms other state-of-the-art supervised multi-omics integrative analysis approaches from different biomedical classification applications using mRNA expression data, DNA methylation data, and microRNA expression data. Furthermore, MOGONET can identify important biomarkers from different omics data types related to the investigated biomedical problems.

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Section: Resultsmentioning

confidence: 99%

MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification

et al. 2021

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“…The beneficial effects of apelin on muscle metabolism are probably mediated by the stimulation of AMP-activated protein kinase and Akt and the resultant mitochondriogenesis [13,27]. Downregulation of apelin in mice exhibited age-dependent decline in multiple organs, whereas systemic restoration of apelin improved cognitive and cardiovascular dysfunction, resulting in increased mammalian health span [8,9,11,12,28]. Because these physiologic alterations including musculoskeletal weakness and neurodegeneration are major manifestations of frailty, apelin could be expected not only as a therapeutic target to slow or reverse aging process but also as a clinical biomarker to assess the frailty status.…”

Section: Discussionmentioning

confidence: 99%

“…Apelin is an active endogenous peptide that acts via G protein-coupled apelin receptor (APJ) to exert diverse functional effects [7]. This pleiotropic molecule is involved in multiple biologic processes, including cardiovascular regulation, neuroprotection, immunity, and glucose metabolism [8][9][10]. Apelin has been recently receiving great attention as a promising target for antiaging intervention, primarily based on results from genetically altered mice [11].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between circulating apelin level and frailty-related functional parameters in older adults: a cross-sectional study

et al. 2020

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Background Apelin, an active endogenous peptide, has been recently receiving great attention as a promising target for antiaging intervention, primarily based on results from genetically altered mice. To validate previous experimental data and investigate the possible role of apelin in humans, in this study, we examined serum apelin level in relation to frailty and its associated parameters in a cohort of ambulatory, community-dwelling older adults. Methods Blood samples were collected from 80 participants who underwent a comprehensive geriatric assessment, and apelin level was measured using an enzyme immunoassay kit. Phenotypic frailty and deficit-accumulation frailty index (FI) were assessed using widely validated approaches, proposed by Fried and Rockwood groups, respectively. Results After adjustment for sex, age, and body mass index, serum apelin level was found to be not significantly different according to phenotypic frailty status (P = 0.550) and not associated with FI, grip strength, gait speed, time to complete 5 chair stands, and muscle mass (P = 0.433 to 0.982). To determine whether the association between serum apelin level and frailty has a threshold effect, we divided the participants into quartiles according to serum apelin level. However, there were no differences in terms of frailty-related parameters and the risk for frailty among the quartile groups (P = 0.248 to 0.741). Conclusions The serum apelin level was not associated with both phenotypic frailty and functional parameters in older adults, despite its beneficial effects against age-related physiologic decline in animal models. Further large-scale longitudinal studies are necessary to understand the definite role of circulating apelin in frailty risk assessment.

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“…Moreover, APLN inhibited the excitotoxicity mediated by N-methyl-D-aspartic acid (NMDA) receptor in the hippocampus of rats (O' Donnell et al, 2007). Apelin may be beneficial to inhibit Alzheimer's disease (AD) pathology by inhibiting the role of Ang II and regulating the PI3K/AKT/GSK-3β signaling pathways to inhibit hyperphosphorylation [58]. The disruption of Ca 2+ homeostasis may be involved in the pathology of neurodegenerative diseases.…”

Section: Apelin In Neurologicalmentioning

confidence: 99%

“…The disruption of Ca 2+ homeostasis may be involved in the pathology of neurodegenerative diseases. APLN shows an inhibitory effect on the development of neurodegenerative diseases by reducing the Ca 2+ concentration caused by increased sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA) activity, suggesting that APLN may be a potential target for the treatment of neurodegenerative diseases [58]. It was reported that epilepsy is associated with increased OS, which may increase susceptibility to attention deficit hyperactivity disorder (ADHD) [16].…”

Section: Apelin In Neurologicalmentioning

confidence: 99%

Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases

Feng

Jiang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Apelin, a peptide hormone, is an endogenous ligand for G protein-coupled receptor and has been shown to be widely expressed in human and animal tissues, such as the central nervous system and adipose tissue. Recent studies indicate that the apelin/APJ system is involved in the regulation of multiple physiological and pathological processes, and it is associated with cardiovascular diseases, metabolic disorders, neurological diseases, ischemia-reperfusion injury, aging, eclampsia, deafness, and tumors. The occurrence and development of these diseases are closely related to the local inflammatory response. Oxidative stress is that the balance between oxidation and antioxidant is broken, and reactive oxygen species are produced in large quantities, causing cell or molecular damage, which leads to vascular damage and a series of inflammatory reactions. Hence, this article reviewed recent advances in the relationship between apelin/APJ and oxidative stress, and inflammation-related diseases, and highlights them as potential therapeutic targets for oxidative stress-related inflammatory diseases.

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Apelin/APJ system: A novel promising target for neurodegenerative diseases

Cited by 43 publications

References 236 publications

MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification

MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification

Lack of association between circulating apelin level and frailty-related functional parameters in older adults: a cross-sectional study

Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases

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