Apelin, Omentin-1, and Vaspin in patients with essential hypertension: association of adipokines with trace elements, inflammatory cytokines, and oxidative damage markers

Cinemre, Fatma Behice Serinkan; Cinemre, Hakan; Bahtiyar, Nurten; Kahyaoğlu, Behlül; Ağaç, Mustafa Tarık; Shundo, Harika; Sevinç, Leyla; Aydemir, Birsen

doi:10.1007/s11845-020-02272-w

Cited by 12 publications

(9 citation statements)

References 55 publications

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“…It is mainly expressed by visceral adipocytes, subcutaneous adipocytes, gastric gland and epidermal adipocytes, and embryonic adipocytes. Not only does Vaspin improve glucose tolerance, maintains insulin sensitivity, and reduces obesity and obesity-related inflammatory complications, but more and more evidences have found that Vaspin also plays a crucial role in cardiovascular and cerebrovascular diseases such as atherosclerosis [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Apelin and Vaspin on Hemorrhagic Transformation in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis and Analysis of Related Factors

Zhu

Yan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Acute ischemic stroke (CIS) is a high-risk condition among the elderly, and intravenous thrombolytic therapy (ITT) is the most effective means for it. However, ITT is prone to induce hemorrhagic transformation (HT) that further threatens the life and health of patients. As paramount substances in cardiovascular and cerebrovascular diseases, adipocyte factor (Apelin) and serine protease inhibitor (Vaspin) are strongly bound up with CIS. Objective. To analyze the predictive significance of Apelin and Vaspin on HT in CIS patients after ITT and offer effective reference to HT prevention in the future. Methods. A total of 109 CIS patients treated with intravenous thrombolysis (IT) in two hospitals between June 2017 and February 2018 were enrolled. Among them, 48 patients who suffered HT after therapy were assigned to the research group (Res group) and the other 61 patients who did not suffer it after therapy were assigned to the control group (Con group). Serum Apelin, Vaspin, inflammatory factors, and oxidative stress levels were quantified, and receiver operating characteristic (ROC) curves were drawn for analyzing the predictive value of Apelin and Vaspin on HT after ITT and their associations with inflammatory factors and oxidative stress. CIS patients who suffered HT were followed up for 3 years for prognostic significance analysis of Apelin and Vaspin. Results. After ITT, the Res group showed lower Apelin and Vaspin levels than the Con group (all P < 0.05 ), and patients with a higher HT grade had lower Apelin and Vaspin levels (all P < 0.05 ). The joint detection of Apelin and Vaspin showed a sensitivity of 77.08% and a specificity of 73.77% for forecasting HT in CIS patients after thrombolytic therapy (all P < 0.001 ). In addition, after thrombolytic therapy, the Res group presented higher levels of interleukin-1β (IL-1β) and IL-6 as well as malondialdehyde (MDA) than the Con group, and the levels had negative associations with Apelin and Vaspin (all P < 0.05 ). The Res group showed a lower superoxide dismutase (SOD) level than the Con group, and the level presented a positive association with Apelin and Vaspin (all P < 0.05 ). According to Logistic analysis, IL-1β, IL-6, and MDA were independent risk factors for HT in CIS patients after IT, while Apelin, Vaspin, and SOD were independent protective factors (all P < 0.05 ). According to the follow-up results, Apelin and Vaspin demonstrated excellent value in forecasting the death of patients with both CIS and HT ( P < 0.05 ), and their lower levels indicate a higher risk of death (all P < 0.05 ). Conclusion. Apelin and Vaspin can help effectively forecast the occurrence of HT in CIS patients after ITT as independent protective factors of HT, so they are of a high clinical application value.

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Section: Introductionmentioning

confidence: 99%

Predictive Value of Apelin and Vaspin on Hemorrhagic Transformation in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis and Analysis of Related Factors

Zhu

Yan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Meanwhile, a decrease in serum Zn levels associated with increased IMA levels has been so far reported in psoriasis patients [ 37 ]. Patients with hypertension record an increase in IMA levels, Cu, Fe, and superoxide dismutase activity, malonaldehyde levels, and a corresponding decrease in Zn levels [ 38 ]. Although IMA levels are implicated in many cancers including prostate cancer [ 39 ], the interaction of serum IMA and Zn levels in cancer is not yet recorded.…”

Section: Resultsmentioning

confidence: 99%

Zinc in Prostate Health and Disease: A Mini Review

Karunasinghe

2022

Biomedicines

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Introduction-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. Method-General information on Zn in biology and multiple aspects of Zn involvement in prostate health and disease were referred to in PubMed. Results-The most influential feature of Zn towards prostate health is its ability to retain sufficient citrate levels for a healthy prostate. Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. There are multiple associations of Zn cellular influx and efflux transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling with prostate cancer outcomes. Such Zn marker variations associated with prostate cancer recorded from biological matrices may improve algorithms for prostate cancer screening, prognosis, and management when coupled with standard clinical practices. Discussion-The influence of Zn in prostatic health and disease is multidimensional, therefore more personalized Zn requirements may be beneficial. Several opportunities exist to utilize and improve understanding of Zn associations with prostate health and disease.

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“…The fact that hypertension and MetS have similar pathophysiological mechanisms and synergistic interactions through changes at the molecular and cellular basis explains the significant difference in circulating omentin-1 levels between the groups in our study. 31 On the other hand, Kilic et al 32 and Vu et al 33 failed to show the relationship between circulating omentin-1 levels and nascent MetS. However, study findings may differ depending on age, study design, inclusion and exclusion criteria, heterogeneity of MetS components in the study populations, ethnic diversity, drug use, and measurement techniques.…”

Section: Original Researchmentioning

confidence: 95%

Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension

Sanlialp

Nar

2022

Journal of Investigative Medicine

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The prevalence of metabolic syndrome (MetS) is more common in patients with hypertension and is associated with an increased risk of target organ damage and/or cardiovascular disease (CVD). Omentin-1 is a beneficial adipokine considered to play a role in MetS and MetS-related states such as obesity, diabetes, and coronary artery disease. The aim of this study was to determine the relationship between circulating omentin-1 levels and MetS uncomplicated by diabetes or CVD (nascent MetS) in patients with hypertension. In this study, 110 patients (54 men, 49%; average age: 49.72±11.32 years) treated for hypertension but without overt diabetes and/or CVD were enrolled. 66 patients were stratified into MetS (+) (group 1) and 44 patients into MetS (−) (group 2) according to the American Heart Association/National Heart, Lung, and Blood Institute criteria. The triglyceride glucose (TyG) index was used to assess insulin resistance. Circulating omentin-1 levels in venous blood samples were measured by an ELISA kit. Circulating omentin-1 levels in patients with MetS were significantly lower than in patients without MetS (46.35 ng/mL (42.70–57.70 ng/mL) vs 130.95 ng/mL (62.83–236.48 ng/mL), p<0.001). Omentin-1 was inversely correlated with TyG index (r=−0.204, p=0.033). In a multivariate logistic regression analysis, omentin-1, TyG index, and body mass index were independent predictors of MetS. A receiver operating characteristic curve analysis determined that the best cut-off value for omentin-1 in predicting MetS was 62.20 ng/mL and the area under the curve was 0.880 (95% CI 0.817 to 0.942, p<0.001). The findings of this study suggest that circulating omentin-1 levels are inversely related to the presence of MetS and may be a reliable marker to predict the development of MetS in patients with hypertension.

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Apelin, Omentin-1, and Vaspin in patients with essential hypertension: association of adipokines with trace elements, inflammatory cytokines, and oxidative damage markers

Cited by 12 publications

References 55 publications

Predictive Value of Apelin and Vaspin on Hemorrhagic Transformation in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis and Analysis of Related Factors

Predictive Value of Apelin and Vaspin on Hemorrhagic Transformation in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis and Analysis of Related Factors

Zinc in Prostate Health and Disease: A Mini Review

Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension

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