APhA Members Elect Sacks, D'Angelo toTop Posts

Sacks, Philip; D'Angelo, Angele C.; Bectel, Maurice Q.; Miller, Jacob W.; Hussar, Daniel A.; Giacolini, Earl; Certo, Natalie M.

doi:10.1016/s0003-0465(16)33682-5

Journal of the American Pharmaceutical Association (1961)

1976

DOI: 10.1016/s0003-0465(16)33682-5

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APhA Members Elect Sacks, D'Angelo toTop Posts

Philip Sacks

Angele C. D'Angelo

Maurice Q. Bectel³

et al.

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“…IT IS WELL known that in the brain glucose is metabolized predominantly via the Embden-Meyerhof (EM) pathway, but the presence of the hexose monophosphate (HMP) pathway and the activation of this pathway by applications of various stimuli in vitro (NISHI-MURA &KIMURA, 1965 andAPPEL &PARROT, 1970) and in vivo (HOSTETLER & LANDAU, 1967) have also been reported. However, several reports indicated that hardly any activity of the HMP was detected in vitro (DI PlETRO & WEINHOUSE, 1959;BLOOM, 1955;SACKS, 1961 andONEILL et al, 1965).…”

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confidence: 99%

ACTIVATION OF HEXOSE MONOPHOSPHATE PATHWAY IN BRAIN BY ELECTRICAL STIMULATION IN VITRO

Kimura

Naito

Nakagawa

et al. 1974

Journal of Neurochemistry

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Abstract— The incubation of cerebral cortical slices for 15 min in Krebs‐Ringer‐tris (pH 7.6) solution at 37°C with [1‐14C]glucose or [6‐14C]glucose as substrates yielded a C‐1:C‐6 14CO2 ratio of 1.21, whereas this ratio increased to 3.01 after the application of electrical stimulation (ES). Tissue levels of 6‐phosphoglu‐conate (6PG) and glucose 6‐phosphate (G6P), intermediary metabolites of hexose monophosphate (HMP) pathway, were 7 and 180 nmol/g tissue following 15 min incubation, and increased by 33 and 45 per cent respectively following the application of ES. Activities of 6‐phosphogluconate dehydrogenase (6PGDH, 6‐phospho‐d‐gluconate: NADP+ 2‐oxidoreductase, EC 1.1.1.44) and glucose‐6‐phosphate dehydrogenase (G6PDH, d‐glucose‐6‐phosphate: NADP+ 1‐oxidoreductase, EC 1.1.1.49), important enzymes in regulating the activity of HMP pathway, in cerebral cortical slices were 689 and 907 pmol/mg protein/min and were increased by 66 and 25 per cent respectively by the application of ES. Synaptosomal G6PDH and 6PGDH activities were maximally activated by the addition of 40 mm‐Na+ to the reaction mixture, whereas no activation by Na+ was observed in microsomal G6PDH and 6PGDH. Amobarbital inhibited more strongly the Embden–Meyerhof (EM) pathway than the HMP pathway, while imipramine had a stronger inhibitory effect on HMP pathway than on EM pathway in the electrically stimulated cerebral tissues. The present results indicate that the HMP shunt pathway in the cerebral cortex is activated by the application of ES in vitro, possibly at synaptic regions and may play an important metabolic and functional role in the brain.

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mentioning

confidence: 99%

ACTIVATION OF HEXOSE MONOPHOSPHATE PATHWAY IN BRAIN BY ELECTRICAL STIMULATION IN VITRO

Kimura

Naito

Nakagawa

et al. 1974

Journal of Neurochemistry

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APhA Members Elect Sacks, D'Angelo toTop Posts

Cited by 1 publication

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ACTIVATION OF HEXOSE MONOPHOSPHATE PATHWAY IN BRAIN BY ELECTRICAL STIMULATION IN VITRO

ACTIVATION OF HEXOSE MONOPHOSPHATE PATHWAY IN BRAIN BY ELECTRICAL STIMULATION IN VITRO

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