Aphasia induced by gliomas growing in the ventrolateral frontal region: Assessment with diffusion MR tractography, functional MR imaging and neuropsychology

Bizzi, Alberto; Nava, Simone; Ferré, Francesca; Castelli, Gianmarco; Aquino, Domenico; Ciaraffa, Francesca; Broggi, Giovanni; DiMeco, Francesco; Piacentini, Sylvie

doi:10.1016/j.cortex.2011.11.015

Cited by 84 publications

(61 citation statements)

References 73 publications

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“…In fact, in our study, there is a high density of speech arrest sites just posterior to the precentral sulcus, immediately behind the superior pars opercularis, but within ventral PMC (Tate et al, 2014). In addition, a recent study examining language deficits in glioma patients demonstrated that gliomas involving the ventral PMC were 5-fold more likely to cause aphasia compared to gliomas involving the inferior frontal gyrus (Bizzi et al, 2012), which also points to the ventral PMC as the primary speech output region. Another potential source for the discrepancy among studies evaluating speech arrest and anomias is related to the specifics of the chosen intraoperative tasks.…”

Section: Broca's Area Is Not the Speech Output Regionsupporting

confidence: 48%

Reply: Probabilistic map of language regions: challenge and implication

Tate

Herbet

Moritz‐Gasser

et al. 2014

Brain

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Section: Broca's Area Is Not the Speech Output Regionsupporting

confidence: 48%

Reply: Probabilistic map of language regions: challenge and implication

Tate

Herbet

Moritz‐Gasser

et al. 2014

Brain

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“…The detailed evaluation of these Auditory sites was beyond the scope of this study, but it is interesting to note that these precentral sites exhibit activity not drastically different from that of the superior temporal gyrus. Indeed, evidence has suggested that some precentral sites maybe have direct white matter connectivity with sites of the superior temporal gyrus (Anwander et al, 2007, Bizzi et al, 2012, Brown et al, 2013, Martino et al, 2012, Perani et al, 2011), supporting old and new theories that the precentral gyrus and language-related motor functions are in tight communication with auditory processing of language in the temporal lobe (Bernal and Ardila, 2009, Luria, 1980). Further work is required to gain a further understanding of this interesting phenomenon of auditory processing near the frontal eye field of the precentral gyrus.…”

Section: Discussionmentioning

confidence: 73%

Evaluating signal-correlated noise as a control task with language-related gamma activity on electrocorticography

Brown¹,

Muzik²,

Robert³

et al. 2014

Clinical Neurophysiology

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Objective Our recent electrocorticography (ECoG) study suggested reverse speech, a widely used control task, to be a poor control for non-language-related auditory activity. We hypothesized that this may be due to retained perception as a human voice. We report a follow-up ECoG study in which we contrast forward and reverse speech with a signal-correlated noise (SCN) control task that cannot be perceived as a human voice. Methods Ten patients were presented 90 audible stimuli, including 30 each of corresponding forward speech, reverse speech, and SCN trials, during ECoG recording with evaluation of gamma activity between 50–150 Hz. Results Sites of the lateral temporal gyri activated throughout speech stimuli were generally less activated by SCN, while some temporal sites seemed to process both human and non-human sounds. Reverse speech trials were associated with activities across the temporal lobe similar to those associated with forward speech. Conclusions Findings herein externally validate functional neuroimaging studies utilizing SCN as a control for non-language-specific auditory function. Our findings are consistent with the notion that stimuli perceived as originating from a human voice are poor controls for non-language auditory function. Significance Our findings have implications in functional neuroimaging research as well as improved clinical mapping of auditory functions.

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“…The degree of cortical and subcortical extension of SMA tumours (as assessed by preoperative MRI and DTI) can help to predict the postoperative course of patients, as previously demonstrated in the case of tumours growing in the ventrolateral frontal region 40. This is important to offer patients a more informed counselling on the postoperative course of the SMA syndrome, as well as to plan in advance an individualised rehabilitative intervention.…”

Section: Discussionmentioning

confidence: 96%

White matter connections of the supplementary motor area in humans

Vergani

Lacerda

Martino

et al. 2014

J Neurol Neurosurg Psychiatry

162

104

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IntroductionThe supplementary motor area (SMA) is frequently involved by brain tumours ( particularly WHO grade II gliomas). Surgery in this area can be followed by the 'SMA syndrome', characterised by contralateral akinesia and mutism. Knowledge of the connections of the SMA can provide new insights on the genesis of the SMA syndrome, and a better understanding of the challenges related to operating in this region. Methods White matter connections of the SMA were studied with both postmortem dissection and advance diffusion imaging tractography. Postmortem dissections were performed according to the Klingler technique. 12 specimens were fixed in 10% formalin and frozen at −15°C for 2 weeks. After thawing, dissection was performed with blunt dissectors. For diffusion tractography, high-resolution diffusion imaging datasets from 10 adult healthy controls from the Human Connectome Project database were used. Whole brain tractography was performed using a spherical deconvolution approach. Results Five main connections were identified in both postmortem dissections and tractography reconstructions: (1) U-fibres running in the precentral sulcus, connecting the precentral gyrus and the SMA; (2) U-fibres running in the cingulate sulcus, connecting the SMA with the cingulate gyrus; (3) frontal 'aslant' fascicle, directly connecting the SMA with the pars opercularis of the inferior frontal gyrus; (4) medial fibres connecting the SMA with the striatum; and (5) SMA callosal fibres. Good concordance was observed between postmortem dissections and diffusion tractography. Conclusions The SMA shows a wide range of white matter connections with motor, language and lymbic areas. Features of the SMA syndrome (akinesia and mutism) can be better understood on the basis of these findings.

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Aphasia induced by gliomas growing in the ventrolateral frontal region: Assessment with diffusion MR tractography, functional MR imaging and neuropsychology

Cited by 84 publications

References 73 publications

Reply: Probabilistic map of language regions: challenge and implication

Reply: Probabilistic map of language regions: challenge and implication

Evaluating signal-correlated noise as a control task with language-related gamma activity on electrocorticography

White matter connections of the supplementary motor area in humans

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