Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats

Gauthaman, K; Adaikan, P.G.; Prasad, R. N. V.

doi:10.1016/s0024-3205(02)01858-1

Cited by 314 publications

(255 citation statements)

References 27 publications

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“…The increased levels of the hormone have been involved in the ability of different medicinal plants to improve sexual function. [10][11][12] The effect shown by the acute administration of Ferula extract dosed at 30 mg/kg, mainly exerted on the appetitive component, may be ascribed to mechanisms other than testosterone.…”

Section: Discussionmentioning

confidence: 99%

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

et al. 2003

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Sexually potent and sluggish/impotent male rats were orally treated with an extract of Ferula hermonis (30 and 60 mg/kg). The acute administration stimulated sexual motivation in potent rats and improved copulatory performance in sluggish/impotent rats. This last effect was elicited only by the higher dose, which, in parallel, increased serum testosterone levels in rats. On the contrary, when the extract was subchronically administered (10 days) a marked reduction in the percentage of rats achieving ejaculation was detected, together with a general impairment of the copulatory pattern. Furthermore, the repeated administration of the extract (6 mg/kg/day for 10 days) resulted in a significant reduction of testosterone levels in comparison with controls. The present results discourage a repeated assumption of F. hermonis, while suggesting its acute administration to improve the performance in sexual dysfunctions.

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Section: Discussionmentioning

confidence: 99%

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

et al. 2003

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“…3 Other studies have shown that TT extract protodioscin increases the levels of testosterone, leutinizing hormone, dihydrotestosterone, and dehydroepiandrosterone sulphate. 4 Treatment of castrated rats with TT resulted in statistically significant increase in prostate weight and intracavernous pressure when compared to placebo. 4 Androstenedione is produced by both the testis and the adrenal glands and serves as a direct precursor of testosterone.…”

Section: Discussionmentioning

confidence: 98%

Priapism caused by ‘All Nite Long’

et al. 2005

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“…as an index of potency and libido, and also a parameter of the rate of recovery from exhaustion after first series of mating (Gauthaman et al, 2002). There was a significant decrease in the post-ejaculatory interval by 33.16%, 60.36% and 56.54% for the 100, 300 and 1000 mg kg -1 Figure 3 Effects of SJE on ejaculatory latency (a) and post-ejaculatory latencies (b) in male mice.…”

Section: Male Sexual Behaviours In Mating Testsmentioning

confidence: 99%

“…This is an indication that the test drug possesses a sexual function improving effect. Premature ejaculation is one of the important causes of sexual dysfunction, so the assessment of ejaculatory latency in first series (EL1) and in second series (EL2) was studied (Gauthaman et al, 2002). Latency to ejaculation in both the first series (10.23%, 159.77%…”

Section: Male Sexual Behaviours In Mating Testsmentioning

confidence: 99%

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The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

Owiredu¹,

Nafiu²,

Amissah³

et al. 2007

Jnl Sci Tech

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Roots of S. jollyanum are considered as sexual stimulant in Ghanaian traditional medicine. The present study is aimed at investigating the effect of an ethanolic extract of the root of S. jollyanum on sexual behaviour of male mice and reproductive hormones in male rats. Extract of S. jollyanum (100, 300 and 1000 mg/kg p.o) stimulated mounting and mating behaviour by increasing mounting frequency, intromission frequency and prolonged ejaculation latency. In addition, a decrease in mounting latency, intromission latency and postejaculatory interval was observed. These observations were indicative of increased libido and enhanced sexual behaviour. However, the dose-response curves of some of the parameters measured (attempted mounts, mounting frequency, anogenital sniffing and penile licking) were U-shaped i.e. the effects observed were absent at higher doses. Also the effect of the extract on FSH, LH, prolactin and testosterone levels in rats were determined at weekly intervals for three weeks. Levels of testosterone were increased 4-fold by the third week and there was about 30% increase in FSH levels by the second week which dropped by the third week. Surprisingly, LH levels were reduced by the second week with no significant change in levels of prolactin. These results suggest that there may be more than one mechanism of action of the extract. The immediate increase in sexual behaviour by extract of S. jollyanum may be due to a central stimulatory effect whilst long-term effect might be due to increased testosterone levels. The stimulation of sexual behaviour in male mice and rats supports the claims for its traditional usage in sexual disorders.

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Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats

Cited by 314 publications

References 27 publications

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats

Priapism caused by ‘All Nite Long’

The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

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