Aphthae (recurrent aphthous stomatitis)

Scully, Crispian

doi:10.1016/b978-0-7020-4948-4.00034-9

Cited by 2 publications

(4 citation statements)

References 40 publications

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“…Study group: Twenty subjects giving a history of recurring oral ulcers and presenting with lesions suggestive of RAS. [ 7 ] Control group: Twenty subjects with healthy oral cavity and no history of any ulcers in the mouth.…”

Section: Methodsmentioning

confidence: 99%

Association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis

Manchanda¹,

Iyengar

Patil

2016

Dent Res J

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Background:Anxiety-related traits have been attributed to sequence variability in the genes coding for serotonin transmission in the brain. Two alleles, termed long (L) and short (S) differing by 44 base pairs, are found in a polymorphism identified in the promoter region of serotonin transporter gene. The presence of the short allele and SS and LS genotypes is found to be associated with the reduced expression of this gene decreasing the uptake of serotonin in the brain leading to various anxiety-related traits. Recurrent aphthous stomatitis (RAS) is an oral mucosal disease with varied etiology including the presence of stress, anxiety, and genetic influences. The present study aimed to determine this serotonin transporter gene polymorphism in patients with RAS and compare it with normal individuals.Materials and Methods:This study included 20 subjects with various forms of RAS and 20 normal healthy age- and gender-matched individuals. Desquamated oral mucosal cells were collected for DNA extraction and subjected to polymerase chain reaction for studying insertion/deletion in the 5-HTT gene-linked polymorphic region. Cross tabulations followed by Chi-square tests were performed to compare the significance of findings, P < 0.05 was considered statistically significant.Results:The LS genotype was the most common genotype found in the subjects with aphthous stomatitis (60%) and controls (40%). The total percentage of LS and SS genotypes and the frequency of S allele were found to be higher in the subjects with aphthous stomatitis as compared to the control group although a statistically significant correlation could not be established, P = 0.144 and 0.371, respectively.Conclusion:Within the limitations of this study, occurrence of RAS was not found to be associated with polymorphic promoter region in serotonin transporter gene.

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Section: Methodsmentioning

confidence: 99%

Association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis

Manchanda¹,

Iyengar

Patil

2016

Dent Res J

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“…RAS se javlja u 20 % opće populacije 3 , a po nekim istraživanjima prevalencija se kreće od 5 do 66 %, ovisno o skupini koja se proučava 4 . Tako je viša prevalencija uočena u osoba višeg socioekonomskog statusa, u osoba koje su više pod utjecajem stresa te u studenata za vrijeme ispitnih rokova 5 .…”

Section: Epidemologijaunclassified

“…Literatura navodi da je etiologija bolesti višeuzročna, odnosno da postoji više predisponirajućih čimbenika u nastanku RAS-a [2][3][4] . Oni se sistematizirano mogu svrstati u 7 većih skupina: genetski, alergijski, imunološki i mibrobni čimbeni-ci, sustavne bolesti, lokalna trauma i psihološki stres 3 .…”

Section: Etiologija I Patogenezaunclassified

“…Smatra se da imunološki čimbenici imaju vodeću ulogu u nastanku lezija, odnosno da je RAS autoimuna bolest posredovana neadekvatnim imunološkim odgovorom prema još uvijek nepoznatom antigenu na keratinocitima 4,12,31 . Reakcija nastaje kao rezultat neadekvatno započete kaskadne aktivnosti citokina koji pokreću procese celularne i humoralne imunosti.…”

Section: Imunološki čImbeniciunclassified

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Reccurent aphthous stomatitis

et al. 2018

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Sažetak. Recidivirajući aftozni stomatitis (RAS) najčešća je upalno-ulcerozna bolest oralne sluznice karakterizirana pojavom bolnih, ovalnih ili okruglih ulceracija s uzdignutim eritematoznim haloom i žućkasto-sivkastom pseudomembranom u središtu. Klinički RAS očituje se u tri oblika: minorni, majorni i herpetiformni RAS. Javlja se u 20 % opće populacije, češće u žena, osoba izloženih stresu te višeg socioekonomskog statusa. Lezije se mogu pojaviti u svakoj životnoj dobi, no najčešće se javljaju u drugom desetljeću života. Usprkos visokoj prevalenciji etiopatogeneza RAS-a još uvijek nije razjašnjena. Ovaj pregledni rad donosi najnovije spoznaje o etiologiji, patogenezi, dijagnostici i liječenju RAS-a.Ključne riječi: aftozni stomatitis; dijagnoza; etiologija; liječenje Abstract. Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative disease of the oral mucosa characterised by painfull, round, or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow-grayish pseudomembrane in the centre. Three clinical subtypes of RAS have been established: minor, major and herpetiform RAS. RAS affects approximately 20% of the population, predominantly affects women, individuals under stress and ones of higher socioeconomic status. The lesions can occur at any age, but they mostly occur in the second life decade. Despite its high prevalence, the etiopathogenesis of RAS still remains unclear. This review article presents the recent knowledge about the etiology, pathogenesis, diagnosis, and treatment of RAS.

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Aphthae (recurrent aphthous stomatitis)

Cited by 2 publications

References 40 publications

Association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis

Association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis

Reccurent aphthous stomatitis

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