Apical periodontitis promotes insulin resistance and alters adaptive immunity markers in rats

Pereira, Renato Felipe; Tessarin, Gestter Willian Lattari; Chiba, Fernando Yamamoto; Mattera, Maria Sara de Lima Coutinho; Pereira, Amanda Gomes; Tsosura, Thaís Verônica Saori; Brito, Victor Gustavo Balera; Oliveira, Renan Akira Fujii de; Ervolino, Edílson; Oliveira, Sandra Helena Penha de; Cintra, Luciano Tavares Ângelo; Matsushita, Dóris Hissako

doi:10.1016/j.sdentj.2021.07.005

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…Possible mechanisms of interaction between endodontic disease and T2DM have been explored by numerous studies, which could provide several explanations for the findings of some observational studies (Bain et al., 2009; Barcelos et al., 2020; Cintra et al., 2014; Felipe Pereira et al., 2021). Studies have reported that the inflammatory response, which impacts insulin sensitivity, plays a crucial role in the development of diabetes (Bloomgarden, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…(2009) established a periapical abscesses model in pregnant rats, they found significant increases of serum TNF‐alpha, blood glucose and serum insulin concentrations in rats with pulpal or periapical abscesses, and concluding periapical abscesses is associated with the development of insulin resistance. Additionally, animal experiments have confirmed that apical periodontitis is associated with higher levels of serum inflammatory cytokines and a more active adaptive immune system, which then leads to the promotion of insulin resistance (Felipe Pereira et al., 2021). Recently, findings from an animal experiment have demonstrated the role of apical periodontitis in changes in antioxidant status and Na+/K+‐ATPase activity, which may be another pathway by which apical periodontitis affects the pathogenesis of type 2 diabetes (Barcelos et al., 2020).…”

Section: Discussionmentioning

confidence: 99%

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Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Wang,

Zhu,

Tang

et al. 2024

Int Endodontic J

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AimThis current Mendelian randomization (MR) study aims to comprehensively explore the potential bidirectional link between pulp and periapical disease (PAP) with type 2 diabetes mellitus (T2DM).MethodologySummary level data of European‐based population genome‐wide association studies (GWASs) were employed to undertake this MR study. With the selection of single nucleotide polymorphisms (SNPs) as the instrumental variable, the radial inverse‐variance weighted (radial IVW) method with modified second‐order weights was applied as the primary method. Additionally, a range of sensitivity analyses were conducted to investigate pleiotropy. Results from different sources of outcome were pooled by meta‐analysis with the fixed model.ResultsThe results of this MR analysis did not suggest a significant impact of pulp and periapical disease on type 2 diabetes (combined OR = 1.04, 95% CI: 1.00–1.07, p = .033) and vice versa (OR = 1.04, 95% CI: 0.96–1.14, p = .329). No significant pleiotropy was detected in the final model after the removal of outliers, demonstrating the reliability of the results in our primary analysis.ConclusionsWith the limitations inherent in the present MR study, there is no significant evidence in either direction to suggest a causal association between pulp and periapical disease and type 2 diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Wang,

Zhu,

Tang

et al. 2024

Int Endodontic J

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“…Chronic infection of AP could cause aggravated and dysregulated inflammatory response, which may result in poor glycemic control and increased insulin requirements ( 49 , 73 , 74 ). Similarly, animal experiments have showed that AP could alter insulin signaling and increase blood glucose concentrations by elevating serum inflammatory cytokines and activating the adaptive immune system ( 74 - 77 ). Maternal alterations in inflammation and insulin signaling pathways caused by AP may directly affect insulin resistance in adult offspring ( 78 ).…”

Section: Metabolic Diseasementioning

confidence: 99%

Interaction between apical periodontitis and systemic disease (Review)

Cao

Song

et al. 2023

Int J Mol Med

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Apical periodontitis is an oral common inflammatory disease initiated by infection of pulp chamber and is characterized by destruction and resorption of the periapical bone. As a local infection, pathogens and their products in periapical tissues, as well as inflammatory cytokines produced in periapical lesions, enter the blood circulation, triggering systemic immune responses and leading to the pathogenesis of various types of systemic disease. Therefore, apical periodontitis might be associated with systemic disease rather than solely simple local oral disease. In addition, the existence of a hyperinflammatory state in certain patients with chronic inflammation-related disorder may affect the progression or prognosis of apical periodontitis. However, the association and potential mechanisms between apical periodontitis and systemic diseases remain unclear. An in-depth understanding of the association between apical periodontitis and systemic disease will be useful for both dentists and physicians to eliminate the possible risk factors and promote the healing of apical periodontitis and systemic disease. Thus, the aim of the present review is to introduce the potential relationship between apical periodontitis and systemic disease.

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SMAD2/3 Phosphorylation is correlated with matrix metalloproteinase 9 expression in human periapical lesions

Wan,

Wang,

et al. 2023

Archives of Oral Biology

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Apical periodontitis promotes insulin resistance and alters adaptive immunity markers in rats

Cited by 6 publications

References 47 publications

Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

Interaction between apical periodontitis and systemic disease (Review)

SMAD2/3 Phosphorylation is correlated with matrix metalloproteinase 9 expression in human periapical lesions

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