Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential
William J. Moss,
Lorenzo Brusini,
Ronja Kuehnel
et al.
Abstract:Apicomplexa encompasses a large number of intracellular parasites infecting a wide range of animals. Cyclic nucleotide signaling is crucial for a variety of apicomplexan life stages and cellular processes. The cyclases and kinases that synthesize and respond to cyclic nucleotides (i.e., 3′,5′-cyclic guanosine monophosphate and 3′,5′-cyclic adenosine monophosphate) are highly conserved and essential throughout the parasite phylum. Growing evidence indicates that phosphodiesterases (PDEs) are also critical for r… Show more
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