Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer

Abstract

The skin is the main barrier between the body and the environment, protecting it from external oxidative stress induced by ultraviolet rays. It also prevents the entrance of infectious agents such as viruses, external antigens, allergens, and bacteria into our bodies. An overreaction to these agents causes severe skin diseases, including atopic dermatitis, pruritus, psoriasis, skin cancer, and vitiligo. Members of the flavonoid family include apigenin, quercetin, luteolin, and kaempferol. Of these, apigenin has been used as a dietary supplement due to its various biological activities and has been shown to reduce skin inflammation by downregulating various inflammatory markers and molecular targets. In this review, we deal with current knowledge about inflammatory reactions in the skin and the molecular mechanisms by which apigenin reduces skin inflammation.

Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin

“…Therefore, we next generalize the representative flavonoids including flavones, flavonols, chalcones, dihydroflavones, dihydroflavonols, isoflavones, and proanthocyanidins in five legumes and show their content in different legumes (Figure ). Both apigenin and diosmetin belong to the flavones subclass, with apigenin being noted for its anticancer and reducing skin inflammation, while diosmetin has potential antihypertensive and vasorelaxant effects. , As shown in Figure A, apigenin was highest in soybean, in small amounts in kidney bean and cowpea, and lacking in the other two legumes. Diosmetin was detected in all four types of beans except peas and was found in the highest amount in kidney beans.…”

“…Both apigenin and diosmetin belong to the flavones subclass, with apigenin being noted for its anticancer and reducing skin inflammation, while diosmetin has potential antihypertensive and vasorelaxant effects. 40,41 As shown in Figure 4A, apigenin was highest in soybean, in small amounts in kidney bean and cowpea, and lacking in the other two legumes. Diosmetin was detected in all four types of beans except peas and was found in the highest amount in kidney beans.…”

Chemical, Nutritional and Biological Evaluation of a Sustainable and Scalable Complex of Phytochemicals from Bergamot By-Products

“…Similar consideration can be drawn for apigenin derivatives (4%), which act by decreasing the levels of pro-inflammatory cytokines and inflammatory mediators by downregulating the MAPK, NfkB and Jak/STAT signaling pathways [ 28 ].…”

Development and Characterization of Chitosan-Based Spray-Dried Solid Dispersions of Apigenin: 3D Printed Shell-Pill for Improved Efficacy of Model Flavonoid

“…AGN has been shown to have antiinflammatory properties by inhibiting the activity of cyclooxygenases (COX) and lipoxygenases (LOX), enzymes involved in the production of prostaglandins and leukotrienes inflammatory molecules and also inhibit the activation of nuclear factor-kappa B (NF-κB), thereby reducing chronic, necrotic and immune regulated inflammation. It's a body's response to injury or infection, but chronic inflammation has been linked to heart disease, 3 of 21 diabetes, and cancer conditions [16], [17]. AGN acts as an anti-cancer agent by regulating the signaling pathways involved in cell cycle progression, angiogenesis, and metastasis, thereby inhibiting the growth of cancer cells, including breast, prostate, colon, lung cancer cells, and reducing the risk of certain types of cancer.…”