Apigenin Ameliorates Lead Acetate induced Hyperlipidemia, Hypothyroidism and Hypogonadism in Male Rats

Algefare, Abdulmohsen I.; Sedky, A.; Alfwuaires, Manal; Mahmoud, Omar

doi:10.21203/rs.3.rs-600247/v1

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The increase in serum TSH levels produced by lead may be linked to structural injury of thyroid follicular cells due to the accumulation of lead in the thyroid gland. This is similar to Algefare et al [54], who observed that the elevation in serum TSH level induced by lead acetate is likely a response to the decrease in serum T4 and T3 levels in rats. Thyroid hormones play essential roles in the development of the central nervous system (CNS).…”

Section: Discussionsupporting

confidence: 90%

Beneficial Role of Echinacea Against Lead Acetate-Induced Brain Toxicity Through Reducing Inflammation, Oxidative Stress and Apoptosis in Rats

Abdel-Monem

Mahmoud

Abbas

2022

Arab Journal of Nuclear Sciences and Applications

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Background: Lead is widely distributed in the environment and has been associated with a variety of negative health impacts. The present study investigated the use of Echinacea with lead acetate in decreasing or preventing the serious side effects of lead on the brains of male rats. Methods: Twenty-four rats were distributed into four groups randomly. Group1: Rats orally administered 1ml of distilled water followed by an intraperitoneal (I.P) injection of 1ml of physiological saline (control group). Group2: Rats I.P injected with lead acetate (50 mg/kg b.w/day, 3 days a week for 4 weeks). Group3: Rats orally administered Echinacea (150 mg/kg b.w./day for 4 weeks). Group4: Rats administrated with Echinacea plus lead acetate with the same doses of G2 and G3. Results: Lead exposure resulted in a significant elevation in nitric oxide (NO) production and malondialdehyde (MDA), along with a decline in reduced glutathione (GSH) and enzyme activities of superoxide dismutase (SOD) and catalase (CAT) in the rats' brain. These results were linked with significant increases in aminotransferase enzymes, lactate dehydrogenase (LDH), alkaline phosphatase (ALP) in brain tissues and serum thyroid stimulating hormone (TSH) levels. Abnormal histopathological changes and increased caspase-3 immunopositivity were also observed in comparison to control. The co-treatment with Echinacea in lead-exposed rats improved all of these changes. Conclusions: This study pointed out that Echinacea could be used as an alternative treatment to counteract the negative effects of lead acetate.

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Section: Discussionsupporting

confidence: 90%

Beneficial Role of Echinacea Against Lead Acetate-Induced Brain Toxicity Through Reducing Inflammation, Oxidative Stress and Apoptosis in Rats

Abdel-Monem

Mahmoud

Abbas

2022

Arab Journal of Nuclear Sciences and Applications

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“…In the current study, the exposure to Al 2 O 3 NP s and/or PbAc decreased sperm count and sperm motility while it increased the abnormal sperm count. Comparable impaired sperm parameters were observed in rats exposed to Al 2 O 3 NP s [ 5 ] or PbAc [ 38 , 99 ]. The reduction in sperm motility was most likely caused by the influence of Al 2 O 3 NP s on mitochondrial function.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

et al. 2022

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This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al2O3NPs) on testicular function. Additionally, the probable reproprotective effects of quercetin (QTN) against Al2O3NPs and PbAc co-exposure in male Sprague Dawely rats were assessed. Al2O3NPs (100 mg/kg b.wt.), PbAc (50 mg/kg b.wt.), and QTN (20 mg/kg b.wt.) were orally administered for 60 days. Then, spermiogram, histopathological examinations of the testis and accessory glands, and immunohistochemical detection of androgen receptors (AR) and tumor necrotic factor alpha (TNF-α) were achieved. Moreover, serum levels of male sex hormones and testicular levels of antioxidant indices were estimated. The results showed that Al2O3NPs and/or PbAc caused significant sperm abnormalities, testicular oxidative stress, and histopathological changes. Furthermore, serum testosterone, LH, and FSH levels significantly decreased, while estradiol levels significantly increased. The Al2O3NPs and/or PbAc co-exposed group had more obvious disturbances. Furthermore, QTN co-administration significantly reversed the Al2O3NPs and PbAc-induced testicular histopathological alterations, reduced antioxidant defenses, and altered AR and TNF-α immune expression in testicular tissues. Conclusively, Al2O3NPs and/or PbAc evoked testicular dysfunction by inducing oxidative injury and inflammation. However, QTN oral dosing effectively mitigated the negative effects of Al2O3NPs and PbAc by suppressing oxidative stress and inflammation and improving the antioxidant defense system.

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The Role of Apigenin in Alleviating the Impact of Environmental Pollutants

Gaur,

Siddique

2025

CBC

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Environmental pollutants pose a serious risk to human health and are a factor in the emergence of many diseases and disorders. In recent years, the research for efficient defence against these pollutants has focused much interest. Natural flavonoid apigenin in various fruits and vegetables has shown great defence against environmental toxins. This review aims to summarize the current knowledge regarding the protective effect of apigenin environmental pollutants and its underlying mechanisms. The study starts by summarizing the main industrial chemicals, environmental pollutants, water contaminants, and the health hazards they provide. The article discusses apigenin's bioactive attributes and focuses on its anti-inflammatory, detoxifying, and antioxidant activities. Previous studies have shown that apigenin supplementation can reduce oxidative stress, inflammation, DNA damage, and organ toxicity from pollutants. The molecular processes behind apigenin's anti-inflammatory effects are explored, including its interactions with important signaling networks. Additional research is required to assess its ideal dosage, bioavailability, and potential interactions with other drugs. Moreover, more human studies are required to evaluate the long-term advantages and safety of apigenin supplementation as a defence against the harmful health consequences of environmental contaminants.

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Apigenin Ameliorates Lead Acetate induced Hyperlipidemia, Hypothyroidism and Hypogonadism in Male Rats

Cited by 3 publications

References 14 publications

Beneficial Role of Echinacea Against Lead Acetate-Induced Brain Toxicity Through Reducing Inflammation, Oxidative Stress and Apoptosis in Rats

Beneficial Role of Echinacea Against Lead Acetate-Induced Brain Toxicity Through Reducing Inflammation, Oxidative Stress and Apoptosis in Rats

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

The Role of Apigenin in Alleviating the Impact of Environmental Pollutants

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