Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway

Zhao, Fenxian; Dang, Yuhui; Zhang, Ruiping; Jing, Guangzhuang; Liang, Weitao; Xie, Li'ao; Li, Zhilan

doi:10.1016/j.intimp.2019.105697

Cited by 43 publications

(12 citation statements)

References 47 publications

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“…Chemically, flavonoids possess the basic structure of a chromone (1,4-benzopyrone) moiety connected to a phenyl ring at position 2. Numerous flavonoids have been found to attenuate inflammatory responses through down-regulating the TLR4/NF-κB signaling pathway, NLRP3 inflammasome activation and the MAPK signaling pathway [ [57] , [58] , [59] , [60] , [61] ], as well as prevent oxidative stress through activating the Nrf2 signaling pathway [ 62 , 63 ]. Due to these activities, flavonoids can prevent ALI, ulcerative colitis, osteoporosis, non-alcoholic fatty liver disease, Alzheimer's disease and other diseases [ 64 ].…”

Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

248

121

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Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

248

121

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“…(Continued) (195). It acts as potent M1-M2 modulator in adipose tissue macrophages by blocking the inflammatory processes via PPARg, and it suppresses obesity-related inflammation (196,197).…”

Section: Apimentioning

confidence: 99%

The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-κB-Mediated Inflammation

2021

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Innate immune response induces positive inflammatory transducers and regulators in order to attack pathogens, while simultaneously negative signaling regulators are transcribed to maintain innate immune homeostasis and to avoid persistent inflammatory immune responses. The gene expression of many of these regulators is controlled by different epigenetic modifications. The remarkable impact of epigenetic changes in inducing or suppressing inflammatory signaling is being increasingly recognized. Several studies have highlighted the interplay of histone modification, DNA methylation, and post-transcriptional miRNA-mediated modifications in inflammatory diseases, and inflammation-mediated tumorigenesis. Targeting these epigenetic alterations affords the opportunity of attenuating different inflammatory dysregulations. In this regard, many studies have identified the significant anti-inflammatory properties of distinct naturally-derived phytochemicals, and revealed their regulatory capacity. In the current review, we demonstrate the signaling cascade during the immune response and the epigenetic modifications that take place during inflammation. Moreover, we also provide an updated overview of phytochemicals that target these mechanisms in macrophages and other experimental models, and go on to illustrate the effects of these phytochemicals in regulating epigenetic mechanisms and attenuating aberrant inflammation.

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“…Of these factors, NO plays a particularly important role in the immune response to inflammation, and other factors are important for the prevention and treatment of tumours (Balez et al 2016;Luan et al 2016). It has been reported that apigenin can restore the increase in apoptosis-related factors such as Cyt-c, Bax, Caspase-9 and Caspase-3 induced by acrylonitrile to some extent (Zhao et al 2019).…”

Section: Construction Of the Compound Databasementioning

confidence: 99%

Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology

Han

Jing

et al. 2021

Pharmaceutical Biology

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Context: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. Objective: To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Materials and methods: Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Streptococcus pneumonia model to verify the results of network pharmacology enrichment analysis. Forty male SPF Sprague Dawley rats were divided into four groups of 10 rats: control (normal saline), model (normal saline), levofloxacin-intervened and RYNM-intervened groups. IL-10, NOS2, COX-1, IL-6, TNF-a and NF-jB in serum and BALF were detected by ELISA. Western blot detected IL-17, IL-6, TNF-a, COX-2 and Bcl-2. Results: The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Streptococcus pneumonia with RYNM. The in vivo experiments indicated that model group has visible inflammation and lesions while RYNM and levofloxacin groups have not. The RYNM exhibited its therapeutic effects on Streptococcus pneumonia mainly via the regulation of cell proliferation and survival through the IL-6/IL-10/IL-17, Bax/Bcl-2, COX-1/COX-2, NF-jB and TNF-a signalling pathways. Discussion and conclusions: The present study demonstrated the protective effects of RYNM on Streptococcus pneumonia, providing a potential mechanism for the treatment of bacterial pneumonia with RYNM.

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Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway

Cited by 43 publications

References 47 publications

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-κB-Mediated Inflammation

Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology

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