Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer

Liu, Lingzhi; Fang, Jing; Zhou, Qiong; Hu, Xiaowen; Shi, Xianglin; Jiang, Bing-Hua

doi:10.1124/mol.105.011254

Cited by 184 publications

(127 citation statements)

References 62 publications

(62 reference statements)

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“…Epidemiological data suggest that consumption of plant flavonoids may be associated with a decreased risk of lung cancer. Liu et al (98) have shown that apigenin inhibited A549 lung cancer cell proliferation and vascular endothelial growth factor (VEGF) transcriptional activation in a dosedependent manner. Apigenin inhibited VEGF transcriptional activation through the HIF-1 binding site, and specifically decreased HIF-1·, but not HIF-1ß subunit expression in these cells.…”

Section: Apigenin and Leukemiamentioning

confidence: 99%

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

Patel

Shukla²,

Gupta³

2007

Int J Oncol

314

362

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Abstract. Cancer is one of the major public health burdens in the United States and in other developed countries, causing approximately 7 million deaths every year worldwide. Cancer rates vary dramatically in different regions and populations around the globe, especially between developing and developed nations. Changes in cancer prevalence patterns occur within regions as their populations age or become progressively urbanized. Migration has also contributed to such variations as changes in dietary habits influence cancer rates. These epidemiologic findings strongly suggest that cancer rates are influenced by environmental factors including diet, which is largely preventable. Approaches to prevent cancer include overlapping strategies viz. chemoprevention or dietary cancer prevention. Chemoprevention aims at prevention or reversal of the initiation phase of carcinogenesis or arrest at progression of carcinogenesis through the administration of naturally occurring constituents or pharmacological agents. Cancer prevention through diet may be largely achievable by increased consumption of fruits and vegetables. Considerable attention has been devoted to identifying plant-derived dietary agents which could be developed as promising chemopreventives. One such agent is apigenin. A naturally occurring plant flavone (4', 5, 7,-trihydroxyflavone) abundantly present in common fruits and vegetables including parsley, onions, oranges, tea, chamomile, wheat sprouts and some seasonings. Apigenin has been shown to possess remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. In the last few years, significant progress has been made in studying the biological effects of apigenin at cellular and molecular levels. This review examines the cancer chemopreventive effects of apigenin in an organ-specificity format, evaluating its limitations and its considerable potential for development as a cancer chemopreventive agent.

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Section: Apigenin and Leukemiamentioning

confidence: 99%

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

Patel

Shukla²,

Gupta³

2007

Int J Oncol

314

362

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“…In 11 days, the Matrigel plugs were removed from the mice and trimmed of the surrounding tissues. Hemoglobin content of the gel plug was measured as described (31). The data represented the mean F SD (n = 8) from two independent experiments.…”

Section: In Vivo Angiogenesis Assaymentioning

confidence: 99%

“…Tumor angiogenesis was done as described previously (31). In brief, DU145 cells were mixed with Matrigel at a ratio of 1:2 (v/v, %), in the presence or absence of chrysin (30 Amol/L); 0.45 mL of the mixture (total cell number = 3 Â 10 6 ) was injected s.c. into the flank sides of BALB/c-nu nude mice (male, 4 weeks old, purchased from Shanghai Experimental Animal Center, Shanghai, China).…”

Section: In Vivo Angiogenesis Assaymentioning

confidence: 99%

Chrysin inhibits expression of hypoxia-inducible factor-1α through reducing hypoxia-inducible factor-1α stability and inhibiting its protein synthesis

Xue

et al. 2007

Molecular Cancer Therapeutics

Self Cite

160

107

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Chrysin is a natural flavonoid and has been shown recently to have anticancer effects. However, the mechanisms that chrysin inhibits cancers are not well known. In this study, we investigated the effects of chrysin on expression of hypoxia-inducible factor-1A (HIF-1A) and vascular endothelial growth factor in human prostate cancer DU145 cells. Chrysin inhibited insulin-induced expression of HIF-1A by reducing its stability. Chrysin increases ubiquitination and degradation of HIF-1A by increasing its prolyl hydroxylation. In addition, chrysin interfered with interaction between HIF-1A and heat shock protein 90. Chrysin was also found to inhibit HIF-1A expression through AKT signaling. Inhibition of HIF-1A by chrysin resulted in abrogation of vascular endothelial growth factor expression. Finally, we showed that chrysin inhibited DU145 xenograft-induced angiogenesis in nude mice. Taken together, these results suggest that chrysin is a potent inhibitor of HIF-1A and provide a new sight into the mechanisms of chrysin against cancers. [Mol Cancer Ther 2007;6(1):220 -6]

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“…Flavonoids and isoflavonoids have potent antioxidant activity relavent to cancer. 50,51) Glycoside linked flavonoids are responsible for antioxidant effects. 43) Isoflavonoids play an important role in prevention of breast cancer, prostrate cancer and atherosclerosis.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Efficacy of Kalpaamruthaa on Lipid Peroxidation and Antioxidant Status in Experimental Mammary Carcinoma in Rats

Ramprasath

Shanthi

Sachdanandam

2006

JOURNAL OF HEALTH SCIENCE

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There has been a growing interest in studying the role played by lipid peroxidation and antioxidant status in breast cancer. Free radicals are found to be involved in both initiation and promotion of multistage carcinogenesis. In the present study, effects of Kalpaamruthaa (KA), a modified Siddha preparation on the levels of lipid peroxides (LPO) and status of antioxidants in several tissues were studied in mammary carcinoma rats. The levels of reactive oxygen species (ROS) were also measured in the control and experimental animals. A significant increase in the levels of LPO, ROS and a decreased levels of antioxidants observed in mammary carcinoma bearing rats were found to be reverted back to near normal levels on treatment with KA. Simultaneous treatment with KA showed more effect than post treatment with KA. Drug control animals showed no significant changes in the levels of ROS when compared with control animals. These results suggest that the free radical mediated damage during mammary carcinoma could have been controlled by KA by its free radical quenching and antioxidative potential. The above results also show that KA exert its anticancer effect on the development of breast cancer.

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Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer

Cited by 184 publications

References 62 publications

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

Apigenin and cancer chemoprevention: Progress, potential and promise (Review)

Chrysin inhibits expression of hypoxia-inducible factor-1α through reducing hypoxia-inducible factor-1α stability and inhibiting its protein synthesis

Therapeutic Efficacy of Kalpaamruthaa on Lipid Peroxidation and Antioxidant Status in Experimental Mammary Carcinoma in Rats

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