2015
DOI: 10.1002/ccr3.361
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Aplasia cutis congenita: a conservative approach of a case with large, extensive skin, and underlying skull defect

Abstract: Key Clinical MessageAplasia cutis congenita is a disease in which skin, bone, and dura mater can be absent. In majority of the cases it affects the scalp. We report a baby girl born at term with a large scalp and skull defect measuring 9 × 10 cm. Conservative treatment led to complete epithelization.

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Cited by 16 publications
(10 citation statements)
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“…For example, recently there was a report on an infant, who had a 9 × 10 cm defect of skin and underlying bone. [ 77 ] These wounds are typically treated with conservative measures, such as dressing changes, over a prolonged time period until healing is achieved. It is easy to appreciate our findings in this dilemma, where the underlying entity has significant intrinsic regenerative potential.…”
Section: Resultsmentioning
confidence: 99%
“…For example, recently there was a report on an infant, who had a 9 × 10 cm defect of skin and underlying bone. [ 77 ] These wounds are typically treated with conservative measures, such as dressing changes, over a prolonged time period until healing is achieved. It is easy to appreciate our findings in this dilemma, where the underlying entity has significant intrinsic regenerative potential.…”
Section: Resultsmentioning
confidence: 99%
“…It most commonly occurs as a solitary defect or in association with other developmental abnormalities (Browning, ). The exact etiology of ACC remains unclear; not only does genetics play a role in the pathogenesis, but also other factors including compromised vasculature, intrauterine trauma, local amniotic adhesions, and exposure to teratogenic agents are possibly implicated (Rocha, Rodrigues, Marques, Pinto, & Gomes, ).…”
Section: Discussionmentioning
confidence: 99%
“…Healing can occur spontaneously through granulation and re-epithelialization from the edges of the normal skin [2]. Handling for small ACC lesions tends to be conservative, including local wound care that will cause granulation and scar healing [3]. Local wound care is recommended for small lesions of less than 3 cm 2 .…”
Section: Discussionmentioning
confidence: 99%
“…These factors included intrauterine trauma, local amniotic adhesions, and exposure to varicella and herpes simplex infection. The teratogenic agents, for example, antithyroid drugs, valproic acid, marijuana, heroin, alcohol, and cocaine may contribute to ACC [3]. The condition also may be associated with abnormalities of chromosomal, ectodermal dysplasias, epidermolysis bullosa, specific teratogens, intrauterine infections, or other malformation syndromes like Adams-Oliver syndrome, SCALP syndrome (nevus sebaceous, central nervous system [CNS] malformations, aplasia cutis congenital, lumbal dermoid, pigmented nevus) and Opitz syndrome [3,4].…”
Section: Introductionmentioning
confidence: 99%
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