Aplasia cutis congenita of the scalp

Martínez‐Lage, Juan F.; Almagro, María-José; Hernández, Francisco L.; Poza, Máximo

doi:10.1007/s00381-002-0654-4

Cited by 33 publications

(28 citation statements)

References 17 publications

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“…Other authors have described the association between misoprostol and ACC 7 . Several drugs may be linked to ACC, like cocaine, which can lead to placental vasoconstriction or fetal vascular disruption causing cranial defects and central nervous system (CNS) anomalies 7 . The use of benzodiazepines has been asssociated with ACC as described by Martínez-Lage et al 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Several drugs may be linked to ACC, like cocaine, which can lead to placental vasoconstriction or fetal vascular disruption causing cranial defects and central nervous system (CNS) anomalies 7 . The use of benzodiazepines has been asssociated with ACC as described by Martínez-Lage et al 7 . Some angiotensinconverting enzyme inhibitors and methrotexate also may be associated with CNS malformations and ACC 1,2 .…”

Section: Discussionmentioning

confidence: 99%

“…Some factors should be considered before choosing one of these therapeutic options, and the two majors are the site of the lesion and the patients clinical status. Some authors have described the urgent surgical intervention for extensive defects overlying the sagittal sinus to prevent hemorrhage and lethal infections 4,[6][7][8][16][17][18] . The size of the skin lesion should be considered too and defects smaller than 1 cm may be expected to heal spontaneously 6 , if they obviously are superficial ones.…”

Section: Discussionmentioning

confidence: 99%

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Aplasia cutis congenita of the scalp

Sperling¹,

Cowper²,

Knopp³

2012

An Atlas of Hair Pathology With Clinical Correlations

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Aplasia cutis congenita of the scalp

Sperling¹,

Cowper²,

Knopp³

2012

An Atlas of Hair Pathology With Clinical Correlations

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“…The goal of treatment is to achieve complete closure of the defect, avoiding major complications such as meningitis, hemorrhages, and trauma to the brain. 13,18 Reported treatments have included surgical closure, conservative management, or a combination of the two. 13,17 Determination of appropriate clinical management during the early stages of life improves survival 8 and is based on the size of the defect, presence of an underlying skull defect, the child's general condition, and his/her associated life expectancy.…”

Section: Discussionmentioning

confidence: 99%

“…13,18 Reported treatments have included surgical closure, conservative management, or a combination of the two. 13,17 Determination of appropriate clinical management during the early stages of life improves survival 8 and is based on the size of the defect, presence of an underlying skull defect, the child's general condition, and his/her associated life expectancy. 4,18 Conservative treatment is advocated by some authors because of its simplicity.…”

Section: Discussionmentioning

confidence: 99%

Management of large scalp and skull defects in a severe case of Adams-Oliver syndrome

Khashab

Rhee

Pierce

et al. 2009

PED

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Adams-Oliver syndrome is a rare congenital disorder that includes congenital scalp and skull defects, variable degrees of terminal transverse limb anomalies, and cardiac malformations. Cutis aplasia occurring in 75% of patients is a potentially life-threatening condition. Large skin defects that cannot be closed primarily present a management dilemma, and may require skin grafting or flaps, or a combination of both operative and conservative modalities. The authors' experience in management of huge scalp and bone defects with the Integra Dermal Regeneration Template and regular dressing changes showed good scalp repair and no serious complications attributed to this approach.

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Picture of the Month—Diagnosis

2010

Arch Pediatr Adolesc Med

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Meningocele M agnetic resonance imaging revealed a 1.5-cm cystic scalp lesion in the midline just superior to the cerebellum. Its enhancement paralleled the cerebrospinal fluid enhancement on all sequences, and it overlaid a skull defect. Craniectomy and excision revealed a meningocele. Most scalp lesions are benign; however, up to 37% of solitary, nontraumatic scalp nodules extend intracranially to the dura mater or brain. 1 A midline location suggests embryologic abnormalities with potential for intracranial communication. At 3 to 5 weeks of development, the cranial neural tube fuses at the midline, followed by separation of the surface ectoderm away from the neural tube. 2 Defective midline fusion results in dysraphism. The differential diagnosis for a congenital midline scalp nodule includes cephaloceles, dermoid cysts, and heterotopic brain tissue in addition to more common entities such as hemangiomas and lipomas. Similarly, a midline scalp ulceration raises concern for aplasia cutis congenita (ACC) and underlying embryologic malformation.

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Aplasia cutis congenita of the scalp

Abstract: We discuss the diverse options for the management of this condition and the feasibility of early surgical repair in the light of the current literature. We also comment on the possible role of benzodiazepines in the genesis of this lesion.

Cited by 33 publications

References 17 publications

Aplasia cutis congenita of the scalp

Aplasia cutis congenita of the scalp

Management of large scalp and skull defects in a severe case of Adams-Oliver syndrome

Picture of the Month—Diagnosis

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