Aplasie cutanée congénitale et antithyroïdiens de synthèse au cours de la grossesse : série de cas et revue de la littérature

Sachs, C.; Tebacher-Alt, Martine; Mark, M; Cribier, B.; Lipsker, Dan

doi:10.1016/j.annder.2016.02.018

Cited by 13 publications

(7 citation statements)

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“…ACC holds an estimated incidence of about 3 in 10,000 births and there has been a total of approximately 500 reported cases in the literature. [ 32 ] The strongest risk factor reported in the literature is the antithyroid drug Methimazole,[ 18 20 21 39 40 55 ] which according to Frieden classification, can be categorized into type 8 ACC. However, cases of ACC are extremely limited due to the very low incidence and, therefore, it is not possible to derive completely accurate epidemiological data.…”

Section: Introductionmentioning

confidence: 99%

“… Chromosomal abnormalities,[ 8 31 ] especially BMS1[ 29 ]; a recent study has also implicated the UBA2 gene and the SUMOylation pathway[ 27 ] Trauma[ 28 53 ] Amniotic irregularities[ 7 ] Intrauterine complications, such as vascular accidents or infection[ 7 9 13 46 50 ] Thrombosis, vascular lesions[ 7 9 15 ] Teratogens: such as misoprostol, benzodiazepines, valproic acid cocaine, methotrexate, ACE inhibitors, methimasol. [ 18 35 39 40 44 50 ] …”

Section: Introductionmentioning

confidence: 99%

“…Teratogens: such as misoprostol, benzodiazepines, valproic acid cocaine, methotrexate, ACE inhibitors, methimasol. [ 18 35 39 40 44 50 ]…”

Section: Introductionmentioning

confidence: 99%

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Aplasia cutis congenita: Two case reports and discussion of the literature

Blionas¹,

Giakoumettis²,

Antoniades³

et al. 2017

Surg Neurol Int

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Background:Aplasia cutis congenita (ACC) is a part of a heterogeneous group of conditions characterized by the congenital absence of epidermis, dermis, and in some cases, subcutaneous tissues or bone usually involving the scalp vertex. There is an estimated incidence of 3 in 10,000 births resulting in a total number of 500 reported cases to date. The lesions may occur on every body surface although localized scalp lesions form the most frequent pattern (70%). Complete aplasia involving bone defects occurs in approximately 20% of cases. ACC can occur as an isolated defect or can be associated with a number of other congenital anomalies such as limb anomalies or embryologic malformations. In patients with large scalp and skull defects, there is increased risk of infection and bleeding along with increased mortality and therefore prompt and effective management is advised.Case Description:We describe two cases of ACC, involving a 4 × 3 cm defect managed conservatively and a larger 10 × 5 cm defect managed surgically with the use of a temporo-occipital scalp flap. Both cases had an excellent outcome.Conclusions:Multiple treatment regimens exist for ACC, but there is no consensus on treatment strategies. Conservative treatment has been described and advocated, but many authors have emphasized the disadvantages of this treatment modality. Decision between conservative and surgical management must be individualized according to lesion size and location.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aplasia cutis congenita: Two case reports and discussion of the literature

Blionas¹,

Giakoumettis²,

Antoniades³

et al. 2017

Surg Neurol Int

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“…The cause of ACC is not known. According to the literature, the most common factors of ACC include foetal chromosomal or genetic abnormalities (particularly BMS1 and UBA2 genetic abnormalities)[3], trauma[4], amniotic fluid or amniotic membrane abnormalities ( e.g ., foetal skin and amniotic membrane adhesion)[5], intrauterine complications ( e.g ., infection)[6], vascular lesions ( e.g ., thrombus and vascular diseases)[7] and the use of teratogenic drugs during pregnancy ( e.g ., cocaine, methotrexate, angiotensin inhibitor)[8]. ACC is diagnosed mainly based on clinical manifestations: Clear skin defects are observed on regions of the body at birth; the defects can be accompanied by defects or hypoplasia of subcutaneous tissues (including muscle and bones); the shape of the defected skin is irregular, which can be sheet-like, in patches, or irregular shapes; and the size and depth of the skin defects also vary.…”

Section: Discussionmentioning

confidence: 99%

Treating aplasia cutis congenita in a newborn with the combination of ionic silver dressing and moist exposed burn ointment: A case report

Lei

Zhang

Wang

et al. 2019

WJCC

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BACKGROUNDAplasia cutis congenita (ACC) in newborns is a condition in which congenital defects or hypoplasia is present in part of the epidermis, dermis and even subcutaneous tissue (including muscle and bones). First reported by Cordon in 1767, ACC is a rare disease with a low incidence of 1/100000 to 3/10000. Currently, there are 500 cases reported worldwide. ACC can be accompanied by other malformations. The onset mechanism of the disease remains unknown but is thought to be correlated to factors such as genetics, narrow uterus, foetal skin and amniotic membrane adhesion, use of teratogenic drugs in early pregnancy and viral infection.CASE SUMMARYIn August 2018, we treated a newborn with ACC on the left lower limbs using a combination of ionic silver dressing and moist exposed burn ointment (MEBO) and achieved a satisfactory treatment outcome. The skin defects were observed on the external genitals and on areas from the left foot to 3/4 of the upper left side. Subcutaneous tissue and blood vessels were observed in the regions with skin defects. The following treatments were provided. First, the wound was rinsed with 0.9% sodium chloride solution followed by disinfection with povidone-iodine twice. And then MEBO was applied to the wound at a thickness of approximately 1 mm. After applying ionic silver dressing, the wound was covered with sterile gauze. The wound dressing was replaced every 2-3 d. At the 4-mo follow-up, the treatment outcome was satisfactory. There was minimal scar tissue formation, and limb function was not impaired.CONCLUSIONThe combination of ionic silver dressing and MEBO to ACC is helpful.

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“…• Intrauterine complications, such as vascular or infection complications 6, 19, 20 ; • Teratogens such as misoprostol, benzodiazepines, valproic acid, cocaine, methotrexate, ACE inhibitors, methimazole 5,8,13,[21][22][23] .…”

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confidence: 99%

Aplasia Cutis Congenita. Case report and literature review

Cohen¹,

Ribeiro²,

Costa³

et al. 2019

jbnc

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Aplasia Cutis Congenita (ACC) is a rare condition characterized by congenital absence of epidermis, dermis and, in some cases, like this one, subcutaneous tissue and bone. It usually involves the scalp vertex. The estimated incidence is 3 in 10,000 births resulting in a total number of 500 reported cases till nowadays. The lesion can occur on everybody surface, but scalp is the most affected region (70% of the cases). In about 20% of cases there is bone lesion. ACC can occur as an isolated defect or can be associated with a number of other congenitally anomalies such as limb anomalies or embryologic malformations. In patients with large scalp and skull defects, there is increased risk of infection and bleeding along with increased mortality and therefore prompt and effective management is advised. Case presentation: We describe a child with ACC involving almost all skull, where it could be seen the brain only with arachnoid membrane. At presentation there was no Cerebral Spinal Fluid (CSF) leakage. And it was managed surgically. The child was operated on one time. It was covered with non-absorbable matrix and the skin was approached. Conclusion: There are multiple treatments for this condition. But there is no consensus on treatment strategies. Conservative treatment can be tried, especially when there is no bone lesion. The treatment must be individualized for each case.

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Aplasie cutanée congénitale et antithyroïdiens de synthèse au cours de la grossesse : série de cas et revue de la littérature

Cited by 13 publications

References 50 publications

Aplasia cutis congenita: Two case reports and discussion of the literature

Aplasia cutis congenita: Two case reports and discussion of the literature

Treating aplasia cutis congenita in a newborn with the combination of ionic silver dressing and moist exposed burn ointment: A case report

Aplasia Cutis Congenita. Case report and literature review

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