Aplastic Anaemia Presenting with Features of Raised Intracranial Pressure

A Child With Pancytopenia and Optic Disc Swelling

“…In studies, researchers describe an association between several types of anemia and papilledema or increased ICP 9,11,12,[31][32][33][34] along with other forms of anemia, including iron deficiency anemia, 35,36 pernicious anemia, 37 hemolytic anemia, 38 and sickle cell anemia. 33 The majority of symptoms resolve with treatment of the underlying condition.…”

“…Severe anemia can cause retinopathy characterized by diffuse intraretinal hemorrhages 8 ; previous case reports have described papilledema in AA. [9][10][11][12] Two main mechanisms of anemia-induced ICP have been proposed. First, overcirculation of blood through the choroid plexus (due to elevated cardiac output occurring secondary to anemia) can cause cerebrospinal fluid (CSF) overproduction.…”

Unusual causes of papilledema: Two illustrative cases

“…[43] reported anemia in 15 of 96 patients who presented with clinical intracranial hypertension. Many types of anemia have been associated with intracranial hypertension, including hemolytic anemia,[49] aplastic anemia,[19253033] sickle cell anemia,[16] iron-deficiency anemia,[82141] anemia secondary to paroxysmal nocturnal hemoglobinuria,[1] and pernicious anemia. [38] In addition to optic disc edema, other ocular findings in patients with anemia include cotton wool spots, nerve fiber layer/preretinal hemorrhages, vitreous hemorrhages, and central retinal vein occlusion.…”