Aplastic Anaemia: Residue Analysis of Chlorinated Hydrocarbons in Human Bone Marrow Biopsy Specimens by High Resolution Gas Chromatography

Anselstetter, V.; Ballschmiter, K.; Dmochewitz, S.; Heimpel, Hermann

doi:10.1159/000206264

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Evidence for other common solvents having a role in the aetiology of aplastic anaemia is less clear and solvents such as pure toluene or xylene are not thought to be marrow toxins (Grasso, 1986). The fact that benzene is concentrated in the fat of the bone marrow may partly account for such a difference in toxicity (Anselstetter et al , 1985). Our results, which indicated a 50% increase in risk following exposure to solvents in the occupational setting, were consistent with this previous literature.…”

Section: Discussionmentioning

confidence: 99%

The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation

Muir¹,

Chilvers

Harriss³

et al. 2003

Br J Haematol

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Summary. Aplastic anaemia is a rare but serious disorder with a high morbidity and mortality rate. The causes of aplastic anaemia are, for the most part, unknown. We report on the hypothesis that aplastic anaemia may be caused by occupational and/or environmental exposures to certain chemicals. The UK Aplastic Anaemia Study was an interview-based case-control study covering the whole of Great Britain. Those patients diagnosed between 1 July 1993 and 20 October 1997, aged £75 years and born and diagnosed in the UK were eligible for the study. Two hundred eligible cases of aplastic anaemia were compared with 387 age-and sex-matched controls. A number of occupational exposures showed increases in risk. In a multivariate model of these exposures the odds ratios (ORs) for solvents/ degreasing agents, pesticides and radiation were >2 and statistically significant. Reported chemical treatment of houses within 5 years of diagnosis had a significantly raised risk for adults [OR ¼ 2AE51, 95% confidence interval (CI) 1AE02-12AE01], particularly for woodworm treatment (OR ¼ 5AE1, 95% CI 1AE5-17AE4). This study identified significant risks associated with self-reported exposure to solvents, radiation and pesticides in the workplace. Self-reported chemical treatment of houses was also associated with an increased risk of developing aplastic anaemia, in keeping with previous literature.

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Section: Discussionmentioning

confidence: 99%

The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation

Muir¹,

Chilvers

Harriss³

et al. 2003

Br J Haematol

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Bone Marrow Progenitor Cells from Chemically Exposed Workers Display an Intrinsic Ability for Autonomous Proliferation

Valadares

Bincoletto

Oliveira

et al. 2005

Immunopharmacology and Immunotoxicology

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In this study, the autonomous proliferation of bone marrow progenitor cells (CFU-C), a pathological phenomenon observed in many hematological abnormalities, was investigated in 31 individuals who had been diagnosed as having neutropenia. Of these subjects, 18 had been chronically exposed (range of exposure 5-30 years) to a variety of petroleum distillates. We observed that the group of exposed individuals presented higher numbers of autonomous CFU-C when compared with those unexposed subjects. In addition, follow-up data demonstrated that 20% of the exposed population (4 of the 18) developed malignant hematological diseases. The autonomous CFU-C obtained from all individuals studied was composed predominantly of macrophages. This suggests an involvement of these cells in the development of hematological abnormalities, probably as a result of increased production of chemical myelotoxic metabolites.

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Aplastic Anaemia: Residue Analysis of Chlorinated Hydrocarbons in Human Bone Marrow Biopsy Specimens by High Resolution Gas Chromatography

Cited by 2 publications

References 6 publications

The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation

The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation

Bone Marrow Progenitor Cells from Chemically Exposed Workers Display an Intrinsic Ability for Autonomous Proliferation

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