Aplastic anemia and dental implant rehabilitation: a clinical trial

Abstract

The purpose of this study was to investigate implant-supported restoration as a technique for restoring missing teeth in patients with aplastic anemia. Recurrent bleeding from wound sites leads to persistent release of iron in the tissue. Excessive iron in tissue is related to clinical findings, including fibrosis, poor wound healing, and high level of angiogenesis, which are possible etiological factors of reduced osseointegration. A 44-year-old female patient with aplastic anemia was treated with multiple endosseous implants throughout the mandible and in the posterior region of the maxilla. After 14 implants were placed, radiological and clinical parameters were assessed during the follow-up period. Marginal bone did not change significantly during the follow-up period. The fine trabecular bone in intimate contact and enclosing the implant fixture was sufficient for successful osseointegration. None of the 14 implants were associated with compilations during the seven-year experimental period. This study suggests that dental implant procedures are a safe and reliable treatment option for restoration of missing dentition in patients with aplastic anemia.

Effects of anemia and peri-operative medication on wound healing in cleft lip and palate patients

“…In a study on wound complications in laryngectomized patients, prior radiation therapy, diabetes mellitus, preoperative hypoalbuminemia, anemia, and thrombocytosis were found to be independent etiological factors for wound complications [11]. In patients with aplastic anemia, it has been shown that anemia can be kept under control without disrupting wound healing during dental implant application [12]. Cleft palate can be associated with Diamond-Blackfan anemia [13,14].…”