Aplastic Anemia Following Varicella Vaccine

Angelini, Paola; Kavadas, Fotini D.; Sharma, Navneet; Richardson, Susan E.; Roifman, Chaim M.; Dror, Yigal; Nofech-Mozes, Yehuda

doi:10.1097/inf.0b013e31819b6c1f

Cited by 20 publications

(20 citation statements)

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“…One of the most feared adverse reactions to vaccines is the development of autoimmune disease. To the best of our knowledge, only six cases of newly diagnosed acquired AA have been reported after vaccination [ [7] , [8] , [9] , [10] , [11] ] ( Table 1 ). However, in general, AA is not recognized as a vaccine-related adverse event [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Severe aplastic anemia after COVID-19 mRNA vaccination: Causality or coincidence?

Tabata

Hosoi

Murata

et al. 2022

Journal of Autoimmunity

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The development of various autoimmune diseases has been reported after COVID-19 infections or vaccinations. However, no method for assessing the relationships between vaccines and the development of autoimmune diseases has been established. Aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome. We report a case of severe AA that arose after the administration of a COVID-19 vaccine (the Pfizer-BioNTech mRNA vaccine), which was treated with allogeneic hematopoietic stem cell transplantation (HSCT). In this patient, antibodies against the SARS-CoV-2 spike protein were detected both before and after the HSCT. After the patient's hematopoietic stem cells were replaced through HSCT, his AA improved despite the presence of anti-SARS-CoV-2 antibodies. In this case, antibodies derived from the COVID-19 vaccine may not have been directly involved in the development of AA. This case suggests that the measurement of vaccine antibody titers before and after allogeneic HSCT may provide clues to the pathogenesis of vaccine-related autoimmune diseases. Although causality was not proven in this case, further evaluations are warranted to assess the associations between vaccines and AA.

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Section: Discussionmentioning

confidence: 99%

Severe aplastic anemia after COVID-19 mRNA vaccination: Causality or coincidence?

Tabata

Hosoi

Murata

et al. 2022

Journal of Autoimmunity

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“…However, the clinical outcome seems highly unpredictable, as the other reported patients post‐HBV, H1N1 influenza, and varicella‐zoster virus vaccines were both paediatric or adults experiencing either transient disease or severe refractory AA requiring bone marrow transplant. 9 , 10 , 11 , 12 , 13 , 14 , 15 …”

mentioning

confidence: 99%

A case of severe aplastic anaemia after SARS‐CoV‐2 vaccination

et al. 2021

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“…Reduced regulatory T cells likely contributed to postvaccine T EM cell expansion. 17,18 Several cases of AA onset or relapse closely following vaccinations or viral infections have been reported [3][4][5][6][7][8]19 ( Figure 2C). However, a causal relationship has not been established, and no study has explored immunological changes induced by immunizations in relapsed AA patients.…”

Section: Resultsmentioning

confidence: 99%

“…Several cases of AA onset or relapse following immunizations have been reported. [3][4][5][6][7][8] Based on these clinical observations, the British Society for Standards in Haematology recommended against vaccinating AA patients treated with immunosuppression because of the concern for triggering AA relapse. 9 However, beyond clinical descriptions of temporal association, evidence to support this recommendation is lacking.…”

Section: Introductionmentioning

confidence: 99%