Aplastic anemia in pregnancy

Hurwitt, Elliott S.; Field, Leonard E.

doi:10.1016/s0002-9378(42)91329-2

Cited by 14 publications

(1 citation statement)

References 14 publications

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“…Of 17 reported cases of pregnancyassociated SAA that we reviewed, only one other reported patient was a teenager. [3][4][5][6][7][8][9][10][12][13][14][15][16][17][18][19][20][21] In that case, a 19-year-old primigravida female was diagnosed at 14 weeks of GA. At 20 weeks of GA she was started on cyclosporine and GM-CSF. She underwent spontaneous labor at 31 weeks of GA.…”

Section: Discussionmentioning

confidence: 99%

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Abdel‐Azim

Jovi-Usude

Balian

et al. 2015

Journal of Pediatric Hematology/Oncology

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Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA.

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Section: Discussionmentioning

confidence: 99%

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Abdel‐Azim

Jovi-Usude

Balian

et al. 2015

Journal of Pediatric Hematology/Oncology

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Die klinische Bedeutung der Schwangerschaftsan�mien

Huber

Schlagetter

1959

Arch. Gynak.

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Prognostic aspects of aplastic anemia in pregnancy

Suda

Omine

Tsuchiya

et al. 1978

Blut

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Our resent experience on six cases of aplastic anemia complicated with pregnancy is described. In addition, 43 similar cases were collected from the literature and reviewed to analyze some prognostic aspects of this relatively rare but potentially serious complication. Clinical and hematological data were treated to extract some clinically meaningful factors in relation to the success and failure of pregnancy. Among initial hematological parameters, no significant difference was found between successful and unsuccessful cases with an exception of hemoglobin concentration. The patients diagnosed as aplastic anemia prior to conception demonstrated an better outcome of pregnancy as well as survival rate of mother when compared with those diagnosed during pregnancy. Mortality has apparently improved after the late 1950's. Success rate of pregnancy before 1958 was 21%, while it was 67% and 71% in the era of 1959-1969 and after 1970, respectively. However, hemorrhage and infection remained to be two major causes of maternal death in both eras. Based on these observations, the currently recommendable attitude to this complication is discussed.

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Aplastic anemia in pregnancy

Cited by 14 publications

References 14 publications

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia

Die klinische Bedeutung der Schwangerschaftsan�mien

Prognostic aspects of aplastic anemia in pregnancy

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