Aplicación del FP-CIT-I-123 en la práctica clínica de pacientes con parkinsonismo

Lozano, S.J. Ortega; Torres, M.D. Martínez del Valle; García, J.M. Jiménez-Hoyuela; García, A. Delgado; Arillo, V. Campos

doi:10.1157/13076640

Cited by 9 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SPECT result (qualitative and quantitative) was related to the MSA subtype. This is to be expected from a pathophysiological point of view, given that SPECT detects nigrostriatal pathway involvement even in the prodromal phase of the disease [7,8]. This affectation is the origin of the parkinsonian clinic (which is mostly present in the MSA-P form) [1,2].…”

Section: Discussionmentioning

confidence: 95%

“…The validity and usefulness of SPECT in the diagnosis of Parkinson's disease (PD), as well as in clinically uncertain parkinsonian syndromes, even in early stages, has so far been demonstrated [7][8][9]. The main indications for SPECT are: (i) differential diagnosis between neurodegenerative parkinsonian syndrome and essential tremor; (ii) distinguishing between Lewy body dementia and other dementias such as Alzheimer's disease; (iii) differential diagnosis between parkinsonism with presynaptic dopamine deficit (such as PD) and secondary parkinsonism (psychogenic, drug-induced, or vascular); and (iv) early detection of parkinsonian syndromes with presynaptic involvement [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Villena-Salinas

Ortega-Lozano

Amrani-Raissouni

et al. 2023

JCM

View full text Add to dashboard Cite

Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder that has no curative treatment. Diagnosis is based on a set of criteria established by Gilman (1998 and 2008) and recently updated by Wenning (2022). We aim to determine the effectiveness of [123I]Ioflupane SPECT in MSA, especially at the initial clinical suspicion. Methods: A cross-sectional study of patients at the initial clinical suspicion of MSA, referred for [123I]Ioflupane SPECT. Results: Overall, 139 patients (68 men, 71 women) were included, 104 being MSA-probable and 35 MSA-possible. MRI was normal in 89.2%, while SPECT was positive in 78.45%. SPECT showed high sensitivity (82.46%) and positive predictive value (86.24), reaching maximum sensitivity in MSA-P (97.26%). Significant differences were found when relating both SPECT assessments in the healthy–sick and inconclusive–sick groups. We also found an association when relating SPECT to the subtype (MSA-C or MSA-P), as well as to the presence of parkinsonian symptoms. Lateralization of striatal involvement was detected (left side). Conclusions: [123I]Ioflupane SPECT is a useful and reliable tool for diagnosing MSA, with good effectiveness and accuracy. Qualitative assessment shows a clear superiority when distinguishing between the healthy–sick categories, as well as between the parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes at initial clinical suspicion.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Villena-Salinas

Ortega-Lozano

Amrani-Raissouni

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…A low-energy, high-resolution collimator was used. The results were evaluated qualitatively with a visual analysis and quantitatively by using predefined Regions of Interest (ROIs) to obtain Striatum/Occipital indices for each striatal nucleus (right S/O and left S/O) and globally (global S/O), the latter being the arithmetic mean of both [17]. The reference area of non-specific uptake was the occipital lobe [18].…”

Section: Methodsmentioning

confidence: 99%

Follow-Up Findings in Multiple System Atrophy from [123I]Ioflupane Single-Photon Emission Computed Tomography (SPECT): A Prospective Study

Villena-Salinas,

Ortega-Lozano,

Amrani-Raissouni

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Background: Multiple system atrophy (MSA) is subdivided into two types: MSA-P (parkinsonian) and MSA-C (cerebellar). Brain SPECT allows for the detection of nigrostriatal involvement, even in the early stages. To date, the scientific literature does not show a consensus on how to follow-up MSA, especially MSA-C. Our aim was to analyze the diagnostic effectiveness of repeat [123I]Ioflupane SPECT for the follow-up of MSA. Methods: A longitudinal observational study on 22 MSA patients (11 males and 11 females). Results: Significant changes were obtained in the quantitative SPECT assessments in the three Striatum/Occipital indices. The qualitative SPECT diagnosis did not show differences between the initial and evolving SPECT, but the neurologist’s clinical suspicion did. Our results showed a brain deterioration of around 31% at 12 months, this being the optimal cut-off for differentiating a diseased subject (capable of solving diagnostic error rate). Previous imaging tests were inconclusive, as they showed less deterioration in the SPECT and quantitative assessments with respect to the group of confirmed patients. Repeated SPECT increased the diagnostic sensitivity (50% vs. 75%) and positive predictive value (72.73% vs. 77%). In addition, repeated SPECT proved decisive in the diagnosis of initial inconclusive cases. Conclusion: Repeat SPECT at 12 months proves useful in the diagnosis and follow-up of MSA.

show abstract

“…Moreover, while in PD the nigrostriatal involvement occurs at the presynaptic terminal, in atypical parkinsonisms (such as MSA) the involvement also occurs at the postsynaptic terminal [42]. Currently, it is not known whether pre-or postsynaptic involvement occurs earlier in MSA [43]. In view of the above, both neuroimaging studies are recommended in the most recent guidelines for the diagnosis of atypical parkinsonism [44].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study between the Diagnostic Effectiveness of Brain SPECT with [123I]Ioflupane and [123I]MIBG Scintigraphy in Multiple System Atrophy

Villena-Salinas,

Ortega-Lozano,

Amrani-Raissouni

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Background: Multiple system atrophy (MSA) is a neurodegenerative disease. It has a fast progression, so early diagnosis is decisive. Two functional imaging tests can be involved in its diagnosis: [123I]Ioflupane SPECT and [123I]MIBG scintigraphy. Our aim is to comparatively analyze the diagnostic performance of both techniques. Methods: 46 patients (24 males and 22 females) with MSA underwent [123I]Ioflupane SPECT and [123I]MIBG scintigraphy. In each of these techniques, qualitative assessment was compared with quantitative assessment. Results: SPECT visual assessment was positive in 93.5% of subjects (S = 95.24%; PPV = 93.02%). A cut-off of 1.363 was established for overall S/O index (S = 85.7%, E = 100%). Visual assessment of scintigraphy was positive in 73.1% (S = 78.57%, PPV = 94.29%). For the delayed heart/medistinum ratio (HMR) a cut-off of 1.43 (S = 85.3, E = 100%) was obtained. For each unit increase in delayed HMR, the suspicion of MSA increased by 1.58 (OR = 1.58, p < 0.05). The quantitative assessment showed an association with the visual assessment for each technique (p < 0.05). Conclusions: Both tests are useful in MSA diagnosis. Comparatively, we did not observe a clear superiority of either. Striatal and myocardial deterioration do not evolve in parallel. Qualitative assessment is crucial in both techniques, together with the support of quantitative analysis. Delayed HMR shows a direct relationship with the risk of MSA.

show abstract

Aplicación del FP-CIT-I-123 en la práctica clínica de pacientes con parkinsonismo

Cited by 9 publications

References 46 publications

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy

Follow-Up Findings in Multiple System Atrophy from [123I]Ioflupane Single-Photon Emission Computed Tomography (SPECT): A Prospective Study

Comparative Study between the Diagnostic Effectiveness of Brain SPECT with [123I]Ioflupane and [123I]MIBG Scintigraphy in Multiple System Atrophy

Contact Info

Product

Resources

About