Aplikasi Response Surface Methodology Pada Optimalisasi Kondisi Proses Pengolahan Alkali Treated Cottonii (ATC)

Nurmiah, Sitti; Syarief, Rizal; Sukarno, Sukarno; Peranginangin, Rosmawaty; Nurmata, Budi

doi:10.15578/jpbkp.v8i1.49

Cited by 39 publications

(41 citation statements)

References 3 publications

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“…Proses optimasi bertujuan untuk mendapatkan rekomendasi beberapa formula baru yang optimal menurut design, formula paling optimal adalah formula dengan nilai desirability maksimum. Desirability yang semakin mendekati nilai 1,0 menunjukkan kemampuan design menghasilkan formula yang mendekati sempurna (17). Komponen formula gel yang dioptimasi adalah Na-CMC dan Propilen glikol dan respon yang digunakan adalah uji pH, daya sebar dan daya lekat.…”

Section: Optimasi Dan Verifikasi Formula Optimal Gel Serbuk Getah Ashunclassified

Optimasi Formula Gel Serbuk Getah Ashitaba (Angelica keiskei Koidzumi) dan Uji Aktivitas Terhadap Lama Penyembuhan Luka Eksisi pada Kelinci

Ittiqo

Wahid

2019

Pharmauho

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Luka eksisi adalah luka yang diakibatkan terpotongnya jaringan oleh goresan benda tajam. Senyawa golongan flavonoid telah dibuktikan secara pre klinis bisa mempercepat penyembuhan luka. Ashitaba mengandung senyawa golongan flavonoid. Sehingga diperkirakan memiliki potensi sebagai obat penyembuh luka. Penelitian ini merupakan penelitian eksperimental, getah ashitaba dibuat sediaan serbuk kering. Optimasi formula gel serbuk getah ashitaba menggunkan metode D-optimal design dengan Software Design Exspert versi 7.1.5. Komponen yang dioptimasi adalah formula standar gel basis natrium karboksimetil selulosa (Na-CMC) dan propilenglikol, respon yang dinilai adalah daya lekat, daya sebar dan pH. Formula optimum yang didapatkan diuji stabilitas. Selanjutnya dilakukan uji efektivitas formula optimum gel terhadap lama penyembuhan luka eksisi pada kelinci. Hewan uji dibagi dalam tiga kelompok penelitian yaitu kelompok kontrol negatif (basis gel), kontrol positif (betadin salap 10%) dan perlakuan menggunakan formula optimum gel serbuk getah ashitaba. Punggung kelinci dibuat luka eksisi sepanjang 3 cm, luka diolesi sampel uji sebanyak tiga kali sehari selama 7 hari. Pengamatan dilakukan dengan mengukur panjang luka selama perlakuan. Data diuji statistik dengan metode ANOVA dilanjutkan dengan uji LSD (Last significant different). Berdasarkan hasil penelitian, kombinasi CMC-Na dan propilenglikol mempengaruhi pH, daya sebar dan daya lekat. Hasil penelitian menunjukkan porsentase formula optimum bahan teroptimasi gel serbuk getah ashitaba yang dihasilkan untuk CMC-Na dan Propilenglikol masing-masing adalah 4,617% dan 10,383% dengan parameter nilai mutu fisik untuk pH 6,08, daya sebar 5,85 cm2, daya lekat 90,44detik. Gel menunjukkan stabiilitas selama proses penyimpanan serta berpotensi sebagai alternatif obat luka eksisiKata kunci: gel, getah ashitaba, luka eksisi, flavonoid

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Section: Optimasi Dan Verifikasi Formula Optimal Gel Serbuk Getah Ashunclassified

Optimasi Formula Gel Serbuk Getah Ashitaba (Angelica keiskei Koidzumi) dan Uji Aktivitas Terhadap Lama Penyembuhan Luka Eksisi pada Kelinci

Ittiqo

Wahid

2019

Pharmauho

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“…This is because kappa carrageenan is sensitive to K + ions in gel formation (Hakim, Wibowo, Arfini, & Peranginangin, 2011). ATC quality is also influenced by several factors including KOH concentration, temperature, and cooking time (Ninghidayati, Nurlaili, Gunardi, & Roesyadi, 2017;Nurmiah, Syarief, Sukarno, Peranginangin, & Nurtama, 2013).…”

Section: Eucheuma Cottonii With the New Scientific Namementioning

confidence: 99%

“…Determination of independent variables was obtained based on the previous studies of researchers regarding general ATC processing under conditions using KOH concentrations in the range of 6 to 10 %, temperatures of 60 to 75 o C and time of 60 to 120 minutes (Basmal et al, 2003;Junaidi, Hutajulu, Sudibyo, Lestari, & Aviana. 2018;Nurmiah et al, 2013;Suryaningrum et al, 2003) presented in Table 1.…”

Section: Experiments Design (Montgomery 2001)mentioning

confidence: 99%

Optimization of Processing Conditions of Alkali Treated Cottonii (ATC) from Sap-free Eucheuma cottonii

Fateha

Wibowo

Santoso

et al. 2019

Squalen Bull. Marine Fisheries Postharvest Biotech.

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Alkali treated cottonii (ATC) is a derivative product of Eucheuma cottoniithat is treated with alkali. This study used raw material of sap-free seaweed for ATC processing. Sap-free seaweed is a seaweed which thallus has been extracted with liquid known as sap. The use of sap-free seaweed as an ATC product is constrained by its low quality, so an effort to improve its quality is needed. Therefore the obejcetive of this Research was to get the optimal conditions of ATC processing. Experimental data were designed and analyzed using Response Surface MethodologyCentral Composite Design (RSM-CCD) using Design Expert 10.0.7® program. The optimization of ATC processing involved three components that were considered influential, namely KOH concentration, temperature, and processing time. Recommendation for optimal conditions issued by RSM-CCD on ATC processing from sap-free seawee d were 6 % KOH concentration at 75 oC for 120 minutes (93.1% desirability). The results of the response analysis showed a yield of 39.47% and a gel strength of 595.32 g/cm2. As a research control, the recommendation of RSMCCD used in ATC processing from nonsap-free seaweed was obtained yield of 36.81% and gel strength of 574.44 g/cm 2. ATC from sap-free seaweed has higher yield and gel strength than that from nonsap-free seaweed. Thismight be due to the sap-free seaweed was obtained using the proper sap extraction process and ATC processingunder optimal conditions, so that the quality of seaweed was better maintained.

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“…Program akan melakukan optimasi berdasarkan data variabel dan data pengukuran respon yang dimasukkan. Tahap optimasi ini memberikan luaran rekomendasi beberapa formula baru yang optimal menurut program yaitu formula dengan nilai desirability maksimum (Badwaik et al 2012;Nurmiah et al 2013).…”

Section: Tahap Optimasiunclassified

The Optimization of Frying Process of Tumpi-tumpi from Milkfish used Response Surface Methodology

et al. 2018

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The Optimization of Frying Process of Tumpi-tumpi from Milkfish used Response Surface MethodologyAbstract Tumpi-tumpi is a traditional food from South and West Sulawesi (ethnic Bugis-Makassar) using fish as raw material. The quality parameters of tumpi-tumpi, especially in terms of oil absorption, color and texture were affected by the condition of the frying process (including the percentage of coating materials, temperature and frying time). This study was aimed to assess the production technology of the tumpi-tumpi through frying process optimization of deep fat frying using Design Expert 7.0® software with Response Surface Methodology (RSM) Box-Behnken Design producing an optimal response. The results showed that the response of color (L value, o hue) and texture (hardness, cohesiveness) of tumpi-tupi were significantly influenced by the percentage of coating materials as well as frying temperature and time. The optimization using software Design Expert 7.0® with RSM Box-Behnken produced the optimal processing formula of 1.5% coating materials, 150 o C frying temperature and 30 s frying time produced the tumpi-tumpi with properties as follows: 62.25 of L (lightness) value indicating a bit light, 78.73 of o hue indicating yellow red color, 15407.60 gs hardness reflecting moderat hardness and 0.51 g/g cohesiveness impressing slight chewy.

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Aplikasi Response Surface Methodology Pada Optimalisasi Kondisi Proses Pengolahan Alkali Treated Cottonii (ATC)

Cited by 39 publications

References 3 publications

Optimasi Formula Gel Serbuk Getah Ashitaba (Angelica keiskei Koidzumi) dan Uji Aktivitas Terhadap Lama Penyembuhan Luka Eksisi pada Kelinci

Optimasi Formula Gel Serbuk Getah Ashitaba (Angelica keiskei Koidzumi) dan Uji Aktivitas Terhadap Lama Penyembuhan Luka Eksisi pada Kelinci

Optimization of Processing Conditions of Alkali Treated Cottonii (ATC) from Sap-free Eucheuma cottonii

The Optimization of Frying Process of Tumpi-tumpi from Milkfish used Response Surface Methodology

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