2022
DOI: 10.1183/23120541.00325-2022
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Apnoea–hypopnoea index of 5 events·h−1as a metabolomic threshold in patients with sleep complaints

Abstract: BackgroundApnoea-hypopnoea index (AHI) forms the basis for severity of obstructive sleep apnoea (OSA), a condition expected to reprogram metabolic pathways in humans. We aimed at identifying the AHI breakpoint from which the majority of significant changes in the systemic metabolome of patients with sleep complaints occur.MethodsIn a prospective observational study on symptomatic individuals, who underwent polysomnography for the diagnosis of OSA, profiles of 187 metabolites including amino acids, biogenic ami… Show more

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