Apo B/Apo A1 Ratio and Its Correlation With Cardiometabolic Risk Factors and Oxidative Stress in Subjects With Metabolic Syndrome

Abstract

Objective: This study was designed to assess the apolipoprotein B (Apo-B), apolipoprotein A (Apo A) and Apo B/Apo A-I ratio in subjects with and withoutmetabolic syndrome andtoevaluate the correlationofApoB/ApoA-Iratiowithoxidative stressmarker andcardiovasculardisease risk. Methods:Atotal of 308 subjects including one hundred and fty- ve cases and one hundred and fty- three controls were recruited for this study. All the subjects were classied according to the NCEPATP III (National cholesterol education program – Adult treatment panel III) criteria for MetS. Anthropometric and clinical characteristics were recorded using clinical Proforma. Blood samples were collected for doing plasma glucose, Lipid prole analysis [Total Cholesterol (TC), Triglyceride (TG), high-density lipoprotein (HDL)], ApoA1, Apo B and oxidative stress marker - Malondialdehyde (MDA). Serum low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and Apo B/Apo A-I ratio were calculated. Comparison of data between the two groups was done by t test. Correlation coefcient of Apo B/ Apo A1 ratio with cadiometabolic risk factors were calculated. Result: We found that cardiometabolic risk factors like abdominal obesity, systolic and diastolic blood pressure, fasting plasma glucose, TG, atherogenic lipoproteins LDL, Apo B, Apo B/Apo A-I ratio and MDA were signicantly high in subjects with MetS whereas anti-atherogenic factor Apo A1 was signicantly low. We also observed that Apo B/AI ratio was positively related to cardiometabolic risk factors and with oxidative stress marker. Conclusion:Apo B/AI ratio was related to metabolic syndrome and was found to be a reliable indicator of cardiovascular risk in MetS.

Association of Apolipoprotein B /Apolipoprotein A-I Ratio with Cardio Metabolic Risk Biomarkers in Type 2 Diabetes Mellitus

“…The combined effect of Apo B and Apo A-I is realized in the Apo B/Apo A-I ratio, which showed a highly significant correlation with cardiometabolic risk biomarkers. Recent studies have used the Apo B/Apo A-I ratio is associated with cardiometabolic risk biomerkers [28]. The findings were consistent with Sahadevan DC et al described a relation between the Apo B/Apo AI ratio and cardiometabolic risk factors in patients with MetS and patients without MetS, and the study reported a higher Apo B/Apo A-I ratio in the MetS subjects than the control subjects [28].…”

“…Recent studies have used the Apo B/Apo A-I ratio is associated with cardiometabolic risk biomerkers [28]. The findings were consistent with Sahadevan DC et al described a relation between the Apo B/Apo AI ratio and cardiometabolic risk factors in patients with MetS and patients without MetS, and the study reported a higher Apo B/Apo A-I ratio in the MetS subjects than the control subjects [28]. Apo B/Apo A-I ratio was positively associated with various cardiometabolic risk factors including TG, WC, systolic and diastolic blood pressure, and fasting plasma glucose, The number of MetS components may have a relationship with Apo B/Apo A-I ratio [12,29].…”