APOA II genotypes frequency and their interaction with saturated fatty acids consumption on lipid profile of patients with type 2 diabetes

Noorshahi, Neda; Sotoudeh, Gity; Djalali, Mahmoud; Eshraghian, M R; Keramatipour, Mohammad; Basiri, Marjan Ghane; Doostan, Farideh; Koohdani, Fariba

doi:10.1016/j.clnu.2015.06.008

Cited by 18 publications

(31 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings can partially explain the role of APOA2 in the metabolism of lipids in obese patients and can identify a population at risk to mitigate the gene effect of risk polymorphisms [17,23] (Table 7). Associated with BMI and food consumption, [17,37], with lower total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol [38] and regulates postprandial response to a saturated fat overload [23]. rs6413453 APOA2 0.10 (A) Probably associated with weight [36].…”

Section: Discussionmentioning

confidence: 99%

“…It also disrupts several motifs and binds various transcription factors. Associated with BMI and food consumption, [37,17], with lower total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol [38] and regulates postprandial response to a saturated fat overload [23]. rs6413453 APOA2 0.10 (A) Probably associated with weight [36].…”

Section: Bioinformatic Analysis: Rs3813627 Is Likely To Affect Bindinmentioning

confidence: 99%

See 1 more Smart Citation

Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI

et al. 2020

View full text Add to dashboard Cite

Background: The interaction between obesity and genetic traits on high density lipoprotein (HDL) levels has been extensively studied. The variance of serum HDL has a strong genetic heritability, although the studied variant only explains a small part of this variation. The goal of this study was to investigate the associations between the apolipoprotein type 2 (APOA2) rs3813627 single nucleotide polymorphism (SNP) and anthropometric and biochemical variables, though body mass index (BMI). Methods: This study included 153 subjects (91 overweight/obese (BMI ≥ 25 kg/m2) and 62 non-obese individuals (BMI < 25 kg/m2)). The APOA2 rs3813627 SNP was selected and genotyped. Genotype analysis was performed to analyze the associations between APOA2 SNPs and anthropometric and biochemical variables through BMI. Results: The APOA2 rs3813627 TT genotype was associated with low HDL levels in comparison with the APOA2 rs3813627 GG and GT genotype in overweight/obese individuals, but not in the non-obese subjects (p < 0.05). The same trend was observed in the apolipoprotein type 1 (APOA1) protein levels (p < 0.05). Correlation analysis revealed a negative correlation between HDL and APOA1 levels and APOA2 rs3813627 SNP under recessive model (p < 0.05). The odds ratio for low HDL levels was 3.76 and 3.94 for low APOA1 levels. The mediation analysis of APOA2 rs3813627 SNP through BMI showed a full mediation on HDL and partial mediation on APOA1 levels (p < 0.05). Bioinformatic analysis showed that rs3813627 lies in the APOA2 promoter and overlaps motifs for several bound transcription factors. Conclusions: On the basis of these data, the APOA2 rs3813627 SNP is associated with low HDL and APOA1 levels susceptibility, and this effect was mediated by an increased BMI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Bioinformatic Analysis: Rs3813627 Is Likely To Affect Bindinmentioning

confidence: 99%

Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this study, 56 overweight (BMI = 25–29.9 kg/m 2 ) and obese (BMI ≥ 30 kg/m 2 ) type 2 diabetes (T2D) patients with a mean age of 56.68 ± 5.95 were selected from the 697 genotype-specified subjects in the earlier study [18]. The patients were matched for gender, age, and BMI and, at the baseline of study, an equal number of patients remained on each genotype of APOA-II (28 people in the TT/TC group and 28 people in the CC group).…”

Section: Methodsmentioning

confidence: 99%

The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism

Moradi

Mahmoudi

Saedisomeolia

et al. 2017

Nutr J

Self Cite

View full text Add to dashboard Cite

BackgroundPeople may have different responses to the same environmental changes. It has been reported that genome variations may be responsible for these differences. Also, HDL subfractions may be influenced by different genetic variations. The aim of the present study was to determine gene-diet interactions and to evaluate the influence of weight loss on HDL subfractions between two genotypes of -265 T>C APOA-II polymorphism.MethodsIn the present study, 56 overweight and obese patients with type 2 diabetes mellitus were selected from 697 genotype-specified subjects. After matching for gender, age and BMI at the beginning of the study, an equal number of patients remained on each genotype of APOA-II (TT/TC and CC group). After a 6-week calorie restriction program, 44 patients completed the study. Serum HDL subfractions, including HDL2 and HDL3 and LCAT activity, were compared between the two genotypes and, before and after the intervention, were separated in each genotype.ResultsSerum concentration of HDL and its subfractions decreased significantly due to the weight loss. A comparison of the mean changes between the genotypes showed that HDL3 significantly decreased in the CC genotype while, in the TT/TC group, the serum concentration of HDL2 was significantly reduced. However, the increase of LCAT activity was not significant among the two genotypes.ConclusionA comparison of mean changes of variables within two genotype groups showed that C homozygote carriers lead to a general shift toward larger size HDL subfractions and T allele carriers shift toward smaller size HDL subfractions after weight loss.

show abstract

“…The current study was performed on 44 overweight and obese type 2 diabetic patients with mean age of 56.68 ± 5.9 years. Participants were selected from 697 patients speci ed before in the study [27]. The APOA-II groups had an equal number of patients (22 individuals in TT/TC group and 22 individuals in CC group) matched for gender, BMI, age, and use of lipid-lowering medications at the beginning of the study.…”

Section: Study Design and Diet Interventionmentioning

confidence: 99%

Genotype-dependent Response to a Low-energy, Moderate Fiber Diet on Brain-Derived Neurotrophic Factor in Patients who are Obese and Overweight with Type 2 Diabetes

nazary-vanani

Yekaninejad

Moradi

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

ObjectiveBrain-Derived Neurotrophic Factor (BDNF) plays a key role in the pathway of the hypothalamus by reducing appetite, controlling body weight and maintaining energy balance. The aim of this study was to investigate the effects of a low-energy, moderate fiber diet on BDNF in obese and overweight type 2 diabetic patients with the APOA-II polymorphism.ResultsSerum BDNF levels increased significantly in the total participants following the low-energy, moderate fiber diet intervention (from 177.54 ± 141.54 pg/ml to 253.79 ± 206.34 pg/ml, p value = 0.025). However, the increase of serum BDNF levels did not signifcanty differ between gentyipc sub-types.

show abstract

APOA II genotypes frequency and their interaction with saturated fatty acids consumption on lipid profile of patients with type 2 diabetes

Abstract: APOA II polymorphism may influence the saturated fatty acid intake required to prevent dyslipidemia in the type 2 diabetic population.

Cited by 18 publications

References 24 publications

Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI

Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI

The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism

Genotype-dependent Response to a Low-energy, Moderate Fiber Diet on Brain-Derived Neurotrophic Factor in Patients who are Obese and Overweight with Type 2 Diabetes

Contact Info

Product

Resources

About