APOBECs and Their Role in Proviral DNA Synthesis

Albin, John S.; Harris, Reuben S.

doi:10.1007/978-1-4614-7291-9_12

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2014

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“…It is generally agreed that enzymatic function is an important component of the restriction mechanism, which results in viral hypermutation and decreased cDNA accumulation [ e.g. (Harris et al, 2003; Mangeat et al, 2003; Yu et al, 2004; Zhang et al, 2003) and recently reviewed in (Albin and Harris, 2013)]. In addition, many have proposed diverse deaminase-independent mechanisms of restriction [ e.g.…”

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confidence: 99%

Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus

2014

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APOBEC3 proteins are DNA cytosine deaminases that restrict the replication of human immunodeficiency virus deficient in the counterdefense protein Vif. Here, we address the capacity of APOBEC3F to restrict via deaminase-dependent and -independent mechanisms by monitoring spreading infections in diverse T cell lines. Our data indicate that only a deaminase-proficient protein is capable of long-term restriction of Vif-deficient HIV in T cells, analogous to prior reports for APOBEC3G. This indicates that the principal mechanism of APOBEC3F restriction is deaminase-dependent.

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