Apocrine and Eccrine Units

Requena, Luís; Sangüeza, Omar P.

doi:10.1007/978-3-319-45704-8_1

Cited by 2 publications

(3 citation statements)

References 52 publications

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“…Malignant sweat gland tumors have a bewildering array of appearances that, together with their rarity and resemblance to metastases from visceral organs, makes diagnosis difficult. 3,5,15,16 In this case, the diagnosis of eccrine ductal carcinoma was facilitated by in situ carcinoma involving a dermal duct that opened onto the epidermal surface at the eyelid margin. Direct continuity with the epidermal surface is characteristic of eccrine ducts, whereas apocrine ducts open into the follicular infundibulum above the entrance of sebaceous ducts.…”

Section: Discussionmentioning

confidence: 94%

“…Direct continuity with the epidermal surface is characteristic of eccrine ducts, whereas apocrine ducts open into the follicular infundibulum above the entrance of sebaceous ducts. 5 The invasive tumor formed glands, tubules, and solid islands typical of eccrine ductal carcinoma. 16–18 Focal areas with a cribriform architecture raised the possibility of adenoid cystic carcinoma, but the authors excluded this diagnosis by the overall pattern of the infiltrative tumor and the lack of strong and diffuse staining of the tumor cells for CD117.…”

Section: Discussionmentioning

confidence: 99%

“…2,4 However, apocrine and eccrine tumors’ histological and immunohistochemical features often overlap, and tumors may have mixed features. 4–6…”

mentioning

confidence: 99%

See 2 more Smart Citations

Eccrine Ductal Carcinoma of the Eyelid

Casale

Uddin

Proia

2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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The authors present the third example of an eccrine ductal carcinoma of the eyelid. A woman in her early 70s presented with a lesion of the central right lower eyelid margin in the vicinity where an actinic keratosis was diagnosed by biopsy 2.75 years previously. Her dermatologist and ophthalmologist monitored the area of actinic keratosis, and it was stable for 2.5 years until the area became ulcerated and thickened with the loss of eyelashes. A wedge resection disclosed a squamous cell carcinoma in situ and a separate eccrine ductal carcinoma. The eccrine ductal carcinoma had in situ tumor thickening, an eccrine duct component, and an invasive tumor infiltrating the tarsal plate and replacing the normal meibomian glands. The invasive eccrine ductal carcinoma only mildly thickened the tarsal plate and was most likely an incidental finding in a biopsy prompted by the squamous cell carcinoma in situ. The 5-year relative survival rate for malignant apocrine-eccrine tumors is approximately 97%, and our patient is alive and without evidence of local or distant tumor recurrence 5.5 years following the excision of her eyelid tumor.

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