Apocrine Carcinoma of the Groin Possibly Associated with Extramammary Paget's Disease

Abstract

Apocrine carcinoma is a rare malignancy with invasive potential. It presents as painless, slow-growing, firm or cystic, red nodules with focal ulcerations. The tumor is capable of hematogenous dissemination to the liver, lungs, and bone as well as lymphatic spread. In addition, apocrine carcinomas cause intra-epidemial pagetoid spread. We report a case of an apocrine carcinoma related with extensive extramammary Paget's disease (EMPD). The relationship between apocrine carcinoma and EMPD remains to be understood. Co-existing cases with apocrine carcinoma and EMPD are discussed to better understand the relationship between these two malignant apocrine tumors.

Primary Cutaneous Mucinous Carcinoma with Extramammary Paget’s Disease: Eccrine or Apocrine?

“…To our knowledge, there have been no reports of EMPD coexisting with eccrine carcinoma in the groin. Instead, four cases of apocrine carcinoma with EMPD in this region have been reported in the English literature [ 14 , 18 - 20 ], which supports apocrine differentiation.…”