Apocrine hidrocystomas of the eyelids are cystic tumors that have their origin in the glandular portion of the apocrine gland; in most cases they cause only mild or absent symptoms, but they may annoy patients when in huge number, usually interfering with the field of view and disfiguring of upper part of the face. Consequently, those affected usually ask these lesions to be removed. Although a solitary lesion can be treated easily with surgical excision, the elimination of multiple lesions may be problematic because of their number and locations. Many approaches were proposed for solving this particular clinical presentation. We present a difficult case of multiple apocrine hidrocystomas successfully treated using carbon dioxide laser with a good cosmetic outcome taking the opportunity for a literature review.