Apocrine hidrocystoma on the tip of a finger

Santos‐Juanes, Jorge; Osuna, Cristina Galache; Río, José Sánchez del; Delas, J. Soto De; Requena, Luis

doi:10.1111/j.1365-2133.2005.06342.x

Cited by 14 publications

(6 citation statements)

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“…To the best of our knowledge, only 4 cases of AH or AC developing on the fingers have been reported. [13][14][15][16] One of these cases was reported by some of us, 15 and we retrospectively believe that the biopsy was too superficial and that it might also represent a misdiagnosis of DPC. However, the patient was lost to follow-up, and the exact diagnosis remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Location on the fingers of AH and AC is extremely rare and documented only in sporadic case reports. [13][14][15][16] We herein describe 6 cases of DPC, including clinical course, histopathologic and immunohistochemical findings, and therapeutic approach in which the initial histopathologic diagnosis by a general pathologist and with a superficial biopsy was AH or AC. However, complete excision of the tumors led to a final diagnosis of DPC.…”

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confidence: 99%

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“Apocrine Hidrocystoma and Cystadenoma”–like Tumor of the Digits or Toes

Molina-Ruiz

Llamas‐Velasco

Rütten

et al. 2016

American Journal of Surgical Pathology

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Digital papillary carcinoma (DPC) is a rare, underreported, and often misdiagnosed malignant tumor of the sweat glands. It is often located on the digits and toes and most commonly occurs in male individuals in their fifties to seventies. Because of lack of pain, slow growth, and an inconspicuous appearance, clinical diagnosis is often missed or delayed. In contrast, apocrine hidrocystoma (AH) is a cystic adenoma that arises from the apocrine secretory coil, and it is extremely rare for AHs to develop on the digits. We report 7 cases of DPC, including clinical course, histopathologic and immunohistochemical findings, and therapeutic approach in which the initial histopathologic diagnosis in all cases was AH or cystadenoma. However, complete excision of the neoplasms led to a final diagnosis of DPC. After an adequate treatment, no recurrence or metastasis was found in any of the cases described. All the cases studied showed similar histopathologic and immunohistochemical findings. The initial incisional biopsy showed large unilocular or multilocular cystic spaces situated within the dermis, lined by a double layer of epithelial cells with tiny papillary structures. No cellular atypia, necrosis, or pleomorphism was observed. However, complete excision revealed neoplastic lesions involving the dermis and/or subcutis, with an infiltrative pattern and papillary projections into luminal spaces. Immunoperoxidase studies showed positivity for CK7, S-100 protein, CEA, p63, smooth muscle actin, and calponin. DPC is a rare but life-threatening malignancy, therefore it is important to be able to identify such a lesion both clinically and histopathologically, treat it, and monitor the patient for the tumor's potential recurrence and metastasis. Pathologists and dermatopathologists should be aware that a histopathologic diagnosis of AH or cystadenoma on the fingers and toes should be established with caution, because probably those lesions represent the superficial and cystic component of an underlying DPC, and a wider excision should be performed.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“Apocrine Hidrocystoma and Cystadenoma”–like Tumor of the Digits or Toes

Molina-Ruiz

Llamas‐Velasco

Rütten

et al. 2016

American Journal of Surgical Pathology

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“…They may arise from cystic dilatation of the apocrine glands. Apocrine hydrocystomas are most commonly located on the head and neck but have also been reported on the chest wall, scalp, ears, vulva, penis, finger, pericoccygeal and anal region 2,4–8 . Some of them are clinically pigmented 1,6–8 .…”

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“…The pathogenesis of apocrine hydrocystoma is unclear; however, this lesion generally arised from a cystic dilatation of apocrine glands due to the retention of secretion 2,3 . Although many of these tumours are solitary, multiple apocrine hydrocystomas have been reported 4,8 …”

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confidence: 99%

“…Clinically, some apocrine hydrocystomas appear as pigmented; because of this pigmentation, these lesions may be confused with benign or malignant pigmented skin lesions including malignant melanoma, blue nevus and pigmented basal cell carcinoma. Pigmented non‐melanocytic epithelial skin tumours, like pigmented basal cell carcinoma, pigmented seborrheic keratosis, pigmented pilomatrixoma, pigmented nodular hidradenoma, pigmented eccrine poroma, melanoachantoma, squamous cell carcinoma, pigmented actinic keratosis, multicentric pigmented Bowen's disease, pigmented apocrine hamartoma, which should be considered in the differential diagnosis 4,7 …”

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