Abstract:The hippocampus is early affected in Alzheimer’s Disease (AD) and altered hippocampal functioning influences normal cognitive aging. Here, we used functional MRI to assess if the APOE ɛ4 allele or a polygenic risk score (PRS) for AD was linked to longitudinal changes in memory-related hippocampal activation also in normal aging (baseline age 50–95, n = 292; n = 182 at four-year follow-up, subsequently non-demented for at least two years). Mixed-models were used to predict level and change in hippocampal activa… Show more
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