APOL1 Nephropathy Risk Variants Through the Life Course: A Review

Itoku, Ai; Isaac, Jaya; Wilson, Scott; Reidy, Kimberly; Kaskel, Frederick

doi:10.1053/j.ajkd.2023.12.014

American Journal of Kidney Diseases

2024

DOI: 10.1053/j.ajkd.2023.12.014

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APOL1 Nephropathy Risk Variants Through the Life Course: A Review

Ai Itoku,

Jaya Isaac,

Scott Wilson

et al.

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2024

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Cited by 2 publications

References 73 publications

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The Dual Burden: Exploring Cardiovascular Complications in Chronic Kidney Disease

Caturano,

Galiero,

Rocco

et al. 2024

Biomolecules

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Chronic kidney disease (CKD) represents a significant global health challenge, affecting millions of individuals and leading to substantial morbidity and mortality. This review aims to explore the epidemiology, cardiovascular complications, and management strategies associated with CKD, emphasizing the importance of preventing cardiovascular disease and early intervention. CKD is primarily driven by conditions such as diabetes mellitus, hypertension, and cardiovascular diseases, which often coexist and exacerbate renal impairment. Effective management requires a multifaceted approach, including lifestyle modifications, pharmacological interventions, and regular monitoring. Dietary changes, such as sodium restriction and a controlled intake of phosphorus and potassium, play a vital role in preserving renal function. Pharmacological therapies, particularly angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and emerging agents like SGLT2 inhibitors, have shown efficacy in slowing disease progression and improving patient outcomes. Furthermore, patients undergoing dialysis face increased cardiovascular risk, necessitating comprehensive management strategies to address both renal and cardiac health. As the landscape of CKD treatment evolves, ongoing research into novel therapeutic options and personalized medical approaches are essential. This review underscores the urgent need for awareness, education, and effective preventive measures to mitigate the burden of CKD and enhance the quality of life for affected individuals.

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The Dual Burden: Exploring Cardiovascular Complications in Chronic Kidney Disease

Caturano,

Galiero,

Rocco

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

Decoding Kidney Pathophysiology: Omics-Driven Approaches in Precision Medicine

Delrue,

Speeckaert

2024

JPM

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Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic and therapeutic approaches usually fail to account for disease heterogeneity, resulting in low efficacy. Precision medicine offers a novel approach to studying kidney disease by combining omics technologies such as genomics, transcriptomics, proteomics, metabolomics, and epigenomics. By identifying discrete disease subtypes, molecular biomarkers, and therapeutic targets, these technologies pave the way for personalized treatment approaches. Multi-omics integration has enhanced our understanding of CKD by revealing intricate molecular linkages and pathways that contribute to treatment resistance and disease progression. While pharmacogenomics offers insights into expected responses to personalized treatments, single-cell and spatial transcriptomics can be utilized to investigate biological heterogeneity. Despite significant development, challenges persist, including data integration concerns, high costs, and ethical quandaries. Standardized data protocols, collaborative data-sharing frameworks, and advanced computational tools such as machine learning and causal inference models are required to address these challenges. With the advancement of omics technology, nephrology may benefit from improved diagnostic accuracy, risk assessment, and personalized care. By overcoming these barriers, precision medicine has the potential to develop novel techniques for improving patient outcomes in kidney disease treatment.

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APOL1 Nephropathy Risk Variants Through the Life Course: A Review

Cited by 2 publications

References 73 publications

The Dual Burden: Exploring Cardiovascular Complications in Chronic Kidney Disease

The Dual Burden: Exploring Cardiovascular Complications in Chronic Kidney Disease

Decoding Kidney Pathophysiology: Omics-Driven Approaches in Precision Medicine

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