Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Abstract

Background The study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI). Methods 311 patients with NSTEMI were enrolled. The demographic, clinical data, blood samples and SYNTAX score were documented. The Pearson linear correlation was used to detect confounding factors linearly correlated with SYNTAX score. The significantly correlated confounding factors were put into the multiple linear regressions. Results The Pearson linear correlation showed that high-density lipoprotein- cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly correlated with Syntax Score ( r = − 0.119, P = 0.044 and r = − 0.182, P = 0.002, respectively). The multiple linear regressions for Syntax Score were built using HDL-C and ApoA1, respectively. After the adjustment of other significantly correlated confounding factors such as white blood cell count (WBC), myohemoglobin (MB), glutamic-oxalacetic transaminase (AST) and creatinine, the ApoA1 still showed significant association with Syntax Score ( β = − 0.151, P = 0.028). The area under curve was (AUC) 0.624 and the optimal cutoff value is 1.07 g/L when using ApoA1 to predict moderate and severe coronary artery lesions. The patients with ApoA1 ≥ 1.07 g/L and < 1.07 g/L have the Syntax Scores of 12.21 ± 11.58 and 16.33 ± 11.53, respectively ( P = 0.001). Conclusions The ApoA1 is the only lipid factor significantly associated with complexity of coronary artery lesion in patients with NSTEMI, the patients with ApoA1 < 1.07 g/L may have more complex coronary artery lesions.

Angiopoietin-like protein 8 accelerates atherosclerosis in ApoE−/− mice

“…A previous study reported that ANGPTL8 has a negative effect on HDL-mediated cholesterol efflux capacity in THP-1 cell models [28]. ApoA1, the main protein component of HDL-C (65%-70%), promotes cellular cholesterol efflux and cholesterol transportation from peripheral tissues to the liver [29]. The results of our study showed the levels of ApoA1 were higher in ANGPTL8knockdown mice and lower in ANGPTL8-overexpression mice.…”

Baseline white blood cell count-to-apolipoprotein A1 ratio as a novel predictor of long-term adverse outcomes in patients who underwent percutaneous coronary intervention: a retrospective cohort study

“…These studies and findings provide strong evidence to support our current research. Furthermore, previous studies suggested that ApoA1 was associated with cardiovascular events in rheumatoid arthritis patients [32] and CAD patients who underwent PCI [33,34]. These studies were in line with our result.…”

Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı

“…SYNTAX score and lipid parameters were evaluated in previous studies. In the group including NSTEMI patients, the relationship between SYNTAX score and HDL value was significant (22), while no relationship was found between low and high SYNTAX score and dyslipidemia in stable CAD (23). Another reason is that the nutritional deficiency that develops on the basis of chronic disease in the presence of severe CAD may have caused the difference to decrease in the advanced stage and the results to be insignificant.…”