Apolipoprotein A1 is negatively associated with male papillary thyroid cancer patients: a cross-sectional study of single academic center in China

Abstract

Background Papillary thyroid cancer (PTC) is the most common type of thyroid cancer and the incidence of PTC has continued to increase over the past decades. Many studies have shown that obesity is an independent risk factor for PTC and obese PTC patients tend to have a relative larger tumor size and higher grade of tumor stage. Obesity is associated with disordered lipid metabolism and the relationship between serum lipids and PTC remains unclear. Therefore, this study aimed to investigate the association between serum lipid level and PTC. Methods We retrospectively analyzed 1018 PTC patients diagnosed and treated in our hospital, all these cases were first diagnosed with PTC and had complete clinical information including ultrasound reports before surgery, serum lipid (CHOL, TG, HDL-c, LDL-c, Apo-A1, Apo-B, Apo-E) results, surgical records and pathological reports. Results None of these lipid markers were associated with tumor size in the whole cohort and in the female group. In the male group, on crude analysis, Apo-A1 showed a marginally association with tumor size, [OR = 0.158 (0.021–1.777)], p = 0.072. After adjusting for age and multifocality, Apo-A1 showed a significant association with tumor size [OR = 0.126 (0.016–0.974)], p = 0.047. This association become more apparent in a young male subgroup, [OR = 0.051 (0.005–0.497)], p = 0.009. CHOL, TG, HDL-c, LDL-c, Apo-B, Apo-E did not show significant association with tumor size. As for LNM, neither in the male group nor in the female group were found to be associated with any serum lipid biomarkers. Conclusion As PTC incidences continues to increase, our findings demonstrated a negatively association between PTC and apoA-1 in male PTC patients, which may contribute to further investigation concerning diagnosing and preventing this most common type of thyroid cancer.

Do metabolic factors increase the risk of thyroid cancer? a Mendelian randomization study

“…( 32 ). Some retrospective observational studies have reported an association between total cholesterol ( 31 ) and apolipoprotein A1 ( 33 ) with thyroid cancer, which is somewhat inconsistent with the results of our study. In the observational study, HDL may be a confounding factor for other lipid profiles.…”

The Role of Apolipoproteins in the Commonest Cancers: A Review

“…This suggests that the role of lipids in aggressive thyroid cancer progression is mediated through APOB. Regardless of the previous findings, another study established that APOB is not associated with tumor size or the rate of lymph node metastasis in male PTC patients [180].…”

“…A recent study found that APOA1 had an inverse relationship with tumor size in male PTC patients, especially in the younger age group after adjusting for age [180]. This study claimed that there was no association between rate of lymph node metastasis in PTC patients and serum APOA1 [180].…”

“…A recent study found that APOA1 had an inverse relationship with tumor size in male PTC patients, especially in the younger age group after adjusting for age [180]. This study claimed that there was no association between rate of lymph node metastasis in PTC patients and serum APOA1 [180]. With regard to medullary thyroid carcinoma (MTC), it was discovered that APOA4 expression is increased, possibly identifying it as a biomarker for MTC diagnosis [181].…”

Correlation analysis of plasma lipid profiles and the prognosis of head and neck squamous cell carcinoma

“…At the same time, we found that the correlation between HDL‐C levels and Apo A‐I levels and the prognosis of HNSCC patients was not entirely consistent, as was the case for LDL‐C and Apo B. These phenomena also occur in other cancers: low Apo A‐I is beneficial to the prognosis of male patients with papillary thyroid cancer, but HDL‐C levels have no significant effect on the prognosis (Ma et al, 2021). In a study of middle‐aged and elderly women, the researchers found that colorectal cancer risk was positively correlated with Apo B levels and negatively correlated with HDL‐C levels, but not with LDL‐C and Apo A‐I (Chandler et al, 2016).…”