Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

Liu, Cun‐Fei; Yang, Qiang; Chen, Xinglin; Liu, Chengyun

doi:10.1089/gtmb.2012.0183

Cited by 13 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This association was previously reported by Maasz et al in European subjects [ 25 ]. A meta-analysis showed that the -1131 T > C polymorphism was significantly associated with the MS risk in Asian populations [ 28 ]. Obese adolescents with the -1131C allele had an increased risk for the development of metabolic syndrome [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome

Ajjemami

Ouatou

Charoute

et al. 2015

J Diabetes Metab Disord

View full text Add to dashboard Cite

BackgroundIn this case–control study we investigated the relative contribution of commons APOA5 polymorphisms and haplotypes to the risk of metabolic syndrome in Moroccan patients.MethodsUsing the International Diabetes Federation (IDF) criteria for metabolic syndrome, the study included 176 patients and 105 controls. We genotyped APOA5 polymorphisms (−1131 T > C, c.56C > G, c.553G > T and c.1259 T > C) by PCR-RFLP analysis. The effects of APOA5 polymorphisms and constructed haplotypes on metabolic syndrome were estimated using logistic regression analyses.ResultsThe statistical analysis showed a significant association between APOA5 -1131 T > C and APOA5 c.56C > G polymorphisms with metabolic syndrome in both Codominant and Dominant models. The APOA5 -1131 T > C polymorphism was associated with increased fasting glucose (p = 0.0295) and reduced HDL levels (p = 0.0091). Carriers of the APOA5 c.56G allele had increased triglyceride levels (p = 0.0435) and waist circumference (p = 0.0122). Similarly the APOA5 1259 T > C variant was associated with increased waist circumference (p = 0.0463). The haplotypes CCGT (OR = 3.223; p = 0.00278) and CGGT (OR = 8.234; p = 0.00534) were significantly associated with susceptibility to metabolic syndrome.ConclusionsOur results confirms the association of APOA5 -1131 T > C and c.56C > G variants with the predisposition to metabolic syndrome complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome

Ajjemami

Ouatou

Charoute

et al. 2015

J Diabetes Metab Disord

View full text Add to dashboard Cite

show abstract

“…Thus, the association of -1131T>C polymorphism with MetS has been shown in Korean [36] and Chinese populations [37]. A meta-analysis also showed the significant association of this polymorphism with MetS in Asian, but not in white people [38]. …”

Section: Discussionmentioning

confidence: 99%

Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study

Halalkhor

Jalali

Hajian‐Tilaki

et al. 2014

J Diabetes Metab Disord

View full text Add to dashboard Cite

BackgroundMetabolic syndrome is an obesity dependent disorder with a worldwide high prevalence. Regarding the high prevalence of Metabolic syndrome in Iran we analyzed the influence of -1131T>C (rs662799) and c.56C>G (S19W, rs3135506) polymorphisms of the novel apolipoprotein gene, ApoA5, on some Metabolic Syndrome indicators in population from north of Iran.Methods199 volunteers from Babol city-Iran were divided in two groups of low (N = 99, TG ≤ 103 mg/dl) and high (N = 100, TG ≥ 150 mg/dl) serum levels of Triglycerides (TG). We amplified the gene fragments containing -1131T>C and c.56C>G polymorphisms by PCR method and revealed the polymorphisms by RFLP analysis.ResultsWe found a significant association (p = 0.016, Independent t-test) between high levels of TG and -1131T>C polymorphism but not between this polymorphism and serum HDL-C concentrations. Carriers of the C allele had a 1.97 times higher odds ratio to be in the high-TG group than those of the TT genotype (95%, CI = 1.05-3.68). We observed no association between -1131T>C polymorphism with either Waist-to-Hip Ratio (WHR) or Body-Mass-Index (BMI). In the case of c.56C>G polymorphism, although it showed a significant relationship with WHR (p = 0/040, Independent t-test), but failed to correlate with either levels of TG (p = 0.594) or HDL-C (p = 0.640) in serum.ConclusionOur study confirms that ApoA5 gene polymorphisms, -1131T>C and c.56C>G are associated with the two criteria of Metabolic Syndrome, TG and WHR, respectively.

show abstract

“…The human APOA5 gene is located at chromosome 11q23 [20], displays a few polymorphisms in the promoter region (e.g., -1131T>C, -3A>G, S19W, IVS3+476G>A, 1259T>C, and G185C), which associated with high plasma triglyceride (TG) levels [23], [25]–[28] and TG-related diseases such as metabolic syndrome [29], atherosclerotic diseases [30] and Alzheimer's disease [31]. Previous meta-analyses have reported that the APOA5 -1131T/C polymorphism is associated with an increased risk for developing metabolic syndrome [32], [33]. Here, we focused on the association between the APOA5 -1131T/C polymorphism and T2DM due to rare studies on other single-nucleotide polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects

Yin

Sun²,

Wang

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundSeveral studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis.MethodsPubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0.ResultsA total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17–1.40, p<0.00001; for C/C vs. T/T: OR = 1.57, 95% CI = 1.35–1.83, p<0.00001; for C/C vs. T/C+T/T: OR = 1.36, 95% CI = 1.18–1.57, p<0.0001; for C/C+T/C vs. T/T: OR = 1.32, 95% CI = 1.16–1.51, p<0.0001). In the subgroup analysis by ethnicity, significant association was also found among Asians (for C allele vs. T allele: OR = 1.31, 95% CI = 1.22–1.40, p<0.00001; for C/C vs. T/T: OR = 1.61, 95% CI = 1.38–1.88, p<0.00001; for C/C vs. T/C+T/T: OR = 1.39, 95% CI = 1.20–1.61, p<0.0001; for C/C+T/C vs. T/T: OR = 1.42, 95% CI = 1.25–1.62, p<0.00001). However, no significant association was found between the APOA5 -1131T/C polymorphism and T2DM risk among Europeans.ConclusionsThe present meta-analysis suggests that the APOA5 -1131T/C polymorphism is associated with an increased T2DM risk in Asian population.

show abstract

Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

Abstract: Our study suggested that the ApoA5 -1131T>C polymorphism was significantly associated with the risk of MetS in Asians, but not in white populations. However, the c.C56G polymorphism was significantly associated with MetS in white populations.

Cited by 13 publications

References 32 publications

Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome

Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome

Association of two common polymorphisms of apolipoprotein A5 gene with metabolic syndrome indicators in a North Iranian population, a cross-sectional study

Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects

Contact Info

Product

Resources

About