Apolipoprotein-AI and AIBP synergetic anti-inflammation as vascular diseases therapy: the new perspective

Jackson, Ampadu O.; Rahman, Ganiyu A.; Long, Shiyin

doi:10.1007/s11010-020-04037-6

Cited by 9 publications

(6 citation statements)

References 115 publications

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“…Apolipoproteins A-IV are important components of the lipoprotein particles that transport cholesterol, triglycerides, and phospholipids through the blood from and toward different tissues. Indeed, lipoproteins have the ability to suppress inflammation, oxidative stress, tissue remodeling, and promote adaptive immunity and host defense [ 77 , 78 , 79 ]. Other proteins were observed at lower levels in the serum of T1 DS horses compared to basal or T1CTRL horses.…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with Boswellia serrata, Verbascum thapsus, and Curcuma longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression

Beghelli

Zallocco

Angeloni

et al. 2023

Life

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Intense exercise can cause inflammation and oxidative stress due to the production of reactive oxygen species. These pathophysiological processes are interdependent, and each one can induce the other, creating a vicious circle. A placebo-controlled blind study was carried out in show jumping horses (n. 16) to evaluate the effects of a commercial dietary supplement (Dolhorse® N.B.F. Lanes srl, Milan, Italy) containing Verbascum thapsus leaf powder (1.42%), Curcuma longa (14.280 mg/kg), and Boswellia serrata (Roxb ex Colebr) (14.280 mg/kg) extracts. Before and after 10 days of dietary supplementation, blood samples were collected to evaluate the protein levels, antioxidants, and inflammatory responses by proteomic analysis or real-time Reverse Transcriptase-Polymerase Chain Reaction (real-time RT-PCR). A total of 36 protein spots, connected to 29 proteins, were modulated by dietary supplementation, whereas real-time RT-PCR revealed a significant downregulation of proinflammatory cytokines (interleukin 1α (p < 0.05) and interleukin-6 (0.005), toll-like receptor 4 (p < 0.05), and IKBKB (p < 0.05) in supplemented sport horses. Immunoglobulin chains, gelsolin, plasminogen, vitamin D binding protein, apolipoprotein AIV, and filamin B were overexpressed, whereas haptoglobin, α-2-HS-glycoprotein, α2-macroglobulin, afamin, amine oxidase, 60S acidic ribosomal protein, and complement fragments 3, 4, and 7 were reduced. No effect was observed on the antioxidant defense systems. The present results suggest this phytotherapy may reinforce the innate immune responses, thus representing a valid adjuvant to alleviate inflammation, which is a pathophysiological process in sport horses.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with Boswellia serrata, Verbascum thapsus, and Curcuma longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression

Beghelli

Zallocco

Angeloni

et al. 2023

Life

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“…Thus, these results showed an advantageous ApoA1 effect on mediating EC survival under pathologic condition and this effect was confirmed by inhibition of the PI3K/Akt downstream cytosolic signaling pathway. Possible beneficial effects related to anti-inflammatory ApoA1 actions were discussed in recent reviews ( Jackson et al, 2021 ; Robert et al, 2021 ). However, to confirm this suggestion, proinflammatory and anti-inflammatory cytokine content in induced mBEC death before and after ApoA1 treatment needs to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A1 Enhances Endothelial Cell Survival in anIn VitroModel of ALS

Garbuzova‐Davis

Willing

2022

eNeuro

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Altered lipoprotein metabolism is considered a pathogenic component of amyotrophic lateral sclerosis (ALS). Apolipoprotein A1 (ApoA1), a major high-density lipoprotein (HDL) protein, is associated with prevention of vascular damage. However, ApoA1’s effects on damaged endothelium in ALS are unknown. This study aimed to determine therapeutic potential of ApoA1 for endothelial cell (EC) repair under a pathologic condition reminiscent of ALS. We performed in vitro studies using mouse brain ECs (mBECs) exposed to plasma from symptomatic G93A SOD1 mice. Dosage effects of ApoA1, including inhibition of the phosphoinoside 3-kinase (PI3K)/Akt signaling pathway and integration of ApoA1 into mBECs were examined. Also, human bone marrow-derived endothelial progenitor cells (hBM-EPCs) and mBECs were co-cultured without cell contact to establish therapeutic mechanism of hBM-EPC transplantation. Results showed that ApoA1 significantly reduced mBEC death via the PI3K/Akt downstream signaling pathway. Also, ApoA1 was incorporated into mBECs as confirmed by blocked ApoA1 cellular integration. Co-culture system provided evidence that ApoA1 was secreted by hBM-EPCs and incorporated into injured mBECs. Thus, our study findings provide important evidence for ApoA1 as a potential novel therapeutic for endothelium protection in ALS. This in vitro study lays the groundwork for further in vivo research to fully determine therapeutic effects of ApoA1 in ALS.

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“…Numerous studies indicate that unmitigated chronic inflammation can increase the risk of various diseases, including but not limited to cancer, cardiovascular disease and various neurological disease 111 . It has been postulated that treatment regimens that decrease or attenuate inflammation may decrease the comorbidity and mortality of certain diseases 112‐114 . Consequently, there has been extensive research conducted to find and develop natural or synthetic compounds for the treatment of inflammation 115 …”

Section: Pharmacological Efficacymentioning

confidence: 99%

“…111 It has been postulated that treatment regimens that decrease or attenuate inflammation may decrease the comorbidity and mortality of certain diseases. [112][113][114] Consequently, there has been extensive research conducted to find and develop natural or synthetic compounds for the treatment of inflammation. 115 In vitro and in vivo studies have reported that the isolates or crude extracts from Ardisia species have antiinflammatory efficacy.…”

Section: Antiinflammatory Efficacymentioning

confidence: 99%

The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review

Liu

et al. 2022

Medicinal Research Reviews

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Medicinal plants are considered to be a critical source of novel compounds and pharmacophores. The genus Ardisia, consisting of approximately 500 species, is the largest genus in the Myrsinaceae family. Ardisia species are widely distributed throughout tropical and subtropical regions of the world and have been used for the treatment of cancer, hypertension, irregular menstruation, gonorrhea, diarrhea and postnatal syndromes, among others. Phytochemical studies of Ardisia species have resulted in the isolation and

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Apolipoprotein-AI and AIBP synergetic anti-inflammation as vascular diseases therapy: the new perspective

Cited by 9 publications

References 115 publications

Dietary Supplementation with Boswellia serrata, Verbascum thapsus, and Curcuma longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression

Dietary Supplementation with Boswellia serrata, Verbascum thapsus, and Curcuma longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression

Apolipoprotein A1 Enhances Endothelial Cell Survival in anIn VitroModel of ALS

The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review

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