Apolipoprotein C-I genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease

Olsson, Bob; Gigante, Bruna; Mehlig, Kirsten; Bergsten, Alicia; Leander, Karin; Fairé, Ulf dé; Lissner, Lauren; Thelle, Dag S.; Carlsson, Lena

doi:10.1016/j.metabol.2010.04.017

Cited by 14 publications

(9 citation statements)

References 35 publications

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“…APOC1 64–88 (25aa) and APOC1 67–88 (22aa) are a nested pair of peptide fragments of apolipoprotein C1 and share a nominal net charge of +4 at physiological pH. Apolipoprotein C1 is generally associated with lipid metabolism, but it has recently been suggested that the protein may also play a role in inflammation [ 26 ]. APOC1 64–88 and APOC1 67–88 exerted significant antimicrobial activity against E. coli , P. aeruginosa and B. cereus , but were not as effective against S. aureus .…”

Section: Resultsmentioning

confidence: 99%

Bioprospecting the American Alligator (Alligator mississippiensis) Host Defense Peptidome

et al. 2015

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Cationic antimicrobial peptides and their therapeutic potential have garnered growing interest because of the proliferation of bacterial resistance. However, the discovery of new antimicrobial peptides from animals has proven challenging due to the limitations associated with conventional biochemical purification and difficulties in predicting active peptides from genomic sequences, if known. As an example, no antimicrobial peptides have been identified from the American alligator, Alligator mississippiensis, although their serum is antimicrobial. We have developed a novel approach for the discovery of new antimicrobial peptides from these animals, one that capitalizes on their fundamental and conserved physico-chemical properties. This sample-agnostic process employs custom-made functionalized hydrogel microparticles to harvest cationic peptides from biological samples, followed by de novo sequencing of captured peptides, eliminating the need to isolate individual peptides. After evaluation of the peptide sequences using a combination of rational and web-based bioinformatic analyses, forty-five potential antimicrobial peptides were identified, and eight of these peptides were selected to be chemically synthesized and evaluated. The successful identification of multiple novel peptides, exhibiting antibacterial properties, from Alligator mississippiensis plasma demonstrates the potential of this innovative discovery process in identifying potential new host defense peptides.

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Section: Resultsmentioning

confidence: 99%

Bioprospecting the American Alligator (Alligator mississippiensis) Host Defense Peptidome

et al. 2015

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“…It has been shown to play some roles in lipid metabolism and inflammation (Olsson et al, 2010). However, with the exception of our previous studies in fish finding that Apoc1 highly exists in embryos, the regulative mechanisms and functions in embryonic development and nutrition remained unexplored.…”

Section: Discussionmentioning

confidence: 88%

BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development

Wang

et al. 2015

Gene

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“…The MTHFR 677C>T polymorphism was determined by the solid-phase minisequencing method as described previously 23. Further information can be found in references,24 – 26 as well as on http://www.intergene.gu.se. All subjects gave their consent to the study, and the protocol was approved by the regional ethics review board, Forskningsetikkommité (Ö 237/2000).…”

Section: Methodsmentioning

confidence: 99%

The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism

Mehlig

Leander

Fairé

et al. 2013

Heart

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Apolipoprotein C-I genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease

Cited by 14 publications

References 35 publications

Bioprospecting the American Alligator (Alligator mississippiensis) Host Defense Peptidome

Bioprospecting the American Alligator (Alligator mississippiensis) Host Defense Peptidome

BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development

The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism

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