Apolipoprotein D facilitate the proliferation of BmNPV

Fei, Shigang; Xia, Junming; Ma, Guangyu; Zhang, Mengmeng; Sun, Jingchen; Feng, Ming; Wang, Yeyuan

doi:10.1016/j.ijbiomac.2022.11.032

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…However, this finding is in contrast to the previously reported neuroprotective effects of ApoD. Further analysis revealed that ApoD facilitates RABV replication, which was consistent with the results of a previous study demonstrating that ApoD facilitates the proliferation of Bombyx mori nuclear polyhedrosis virus (41).…”

Section: Discussionsupporting

confidence: 89%

Apolipoprotein D facilitates rabies virus propagation by interacting with G protein and upregulating cholesterol

Zhang,

Liang,

et al. 2024

Front. Immunol.

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Rabies virus (RABV) causes a fatal neurological disease, consisting of unsegmented negative-strand RNA, which encodes five structural proteins (3′-N-P-M-G-L-5′). Apolipoprotein D (ApoD), a lipocalin, is upregulated in the nervous system after injury or pathological changes. Few studies have focused on the role of ApoD during virus infection so far. This study demonstrated that ApoD is upregulated in the mouse brain (in vivo) and C8-D1A cells (in vitro) after RABV infection. By upregulating ApoD expression in C8-D1A cells, we found that ApoD facilitated RABV replication. Additionally, Co-immunoprecipitation demonstrated that ApoD interacted with RABV glycoprotein (G protein). The interaction could promote RABV replication by upregulating the cholesterol level. These findings revealed a novel role of ApoD in promoting RABV replication and provided a potential therapeutic target for rabies.

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Section: Discussionsupporting

confidence: 89%

Apolipoprotein D facilitates rabies virus propagation by interacting with G protein and upregulating cholesterol

Zhang,

Liang,

et al. 2024

Front. Immunol.

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“…It has been observed that the longevity of R. pedestris fed on soybean leaves is significantly shorter than that of bugs fed on pods and beans, which is positively correlated with the concentration of amino acids and proteins [ 32 , 33 ]. Additionally, several genes associated with growth, such as apolipoprotein D and Sonic hedgehog protein [ 49 , 50 , 51 ], showed significant higher expression when R. pedestris fed on pods and beans. These results support the previous conclusion that pods and beans are more favorable food sources for R. pedestris compared to soybean leaves [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptomic Analysis Reveals Adaptation Mechanisms of Bean Bug Riptortus pedestris to Different Food Resources

Zhang,

Wang,

et al. 2023

Insects

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The bean bug, Riptortus pedestris (Hemiptera: Heteroptera), poses a significant threat to soybean production, resulting in substantial crop losses. Throughout the soybean cultivation period, these insects probe and suck on various parts of plants, including leaves, pods, and beans. However, the specific mechanisms by which they adapt to different food resources remain unknown. In this study, we conducted gut transcriptomic analyses of R. pedestris fed with soybean leaves, pods, and beans. A total of 798, 690, and 548 differently expressed genes (DEGs) were monitored in G—pod vs. G—leaf (comparison of insect feeding on pods and leaves), G—bean vs. G—leaf (comparison of insect feeding on beans and leaves), and G—pod vs. G—bean (comparison of insect feeding on pods and beans), respectively. When fed on pods and beans, there was a significant increase in the expression of digestive enzymes, particularly cathepsins, serine proteases, and lipases. Conversely, when soybean leaves were consumed, detoxification enzymes, such as ABC transporters and 4-coumarate-CoA ligase, exhibited higher expression. Our findings indicate that R. pedestris dynamically regulates different metabolic pathways to cope with varying food resources, which may contribute to the development of effective strategies for managing this pest.

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“…RNA Interference (RNAi) of BmPGRP-S5 in Silkworm Larvae. According to previous studies in the laboratory, 44 newly exuviated fifth instar larvae were injected with dsRNA-PGRP(S5) (6 μg/larva), while control larvae were injected with the same concentration of dsRNA-Red. At 24, 48, and 72 h post-injection, midguts were collected from six larvae from both injected and control groups to determine expression of BmPGRP-S5 by qPCR.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Peptidoglycan Recognition Protein S5 of Bombyx mori Facilitates the Proliferation of Bombyx mori Cypovirus 1

Ren

Yan

Wang

et al. 2023

J. Agric. Food Chem.

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Bombyx mori cypovirus 1 (BmCPV1), a primary pathogen of the silkworm, is a typical dsRNA virus belonging to the Reoviridae family. In this study, a total of 2520 differentially expressed genes (DEGs) were identified by RNA-seq analysis of the silkworm midgut after BmCPV1 infection and Gene Ontology (GO) functional annotation showed that the DEGs predominantly functioned in binding (molecular function), cell (cellular component), and cellular processes (biological process). Additionally, the Kyoto Encyclopedia of Genes and Genomes (KEGG) functional annotation revealed that the DEGs were mainly distributed in global and overview metabolism maps, translation, and signal transduction. Among the identified DEGs, BmPGRP-S5 belongs to the peptidoglycan recognition protein (PGRP) family. Previous studies have revealed that PGRPs were involved in the interactions between silkworm and BmCPV1. Here, we explored the effect of BmPGRP-S5 on BmCPV1 replication and demonstrated that BmPGRP-S5 promotes the proliferation of BmCPV1 in BmN cells through overexpression or knockdown experiments. Knocking down of BmPGRP-S5 in silkworm larvae similarly promoted the proliferation of BmCPV1. Through experimental validation, we therefore determined that BmPGRP-S5 acts as a proviral host factor for BmCPV1 infection. This study clarifies the proliferation mechanism of BmCPV1 and provides new insights into the functional role of BmPGRP-S5.

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Apolipoprotein D facilitate the proliferation of BmNPV

Cited by 6 publications

References 41 publications

Apolipoprotein D facilitates rabies virus propagation by interacting with G protein and upregulating cholesterol

Apolipoprotein D facilitates rabies virus propagation by interacting with G protein and upregulating cholesterol

Comparative Transcriptomic Analysis Reveals Adaptation Mechanisms of Bean Bug Riptortus pedestris to Different Food Resources

Peptidoglycan Recognition Protein S5 of Bombyx mori Facilitates the Proliferation of Bombyx mori Cypovirus 1

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