Apolipoprotein E (APOE) ε4 and episodic memory decline in Alzheimer’s disease: A review

Haj, Mohamad El; Antoine, Pascal; Amouyel, Philippe; Lambert, Jean‐Charles; Pasquier, Florence; Kapogiannis, Dimitrios

doi:10.1016/j.arr.2016.02.002

Cited by 75 publications

(43 citation statements)

References 158 publications

(95 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with prior findings [43], the ε4 carriers in our sample had significantly greater decline in episodic memory than non-carriers, which was independent of the longitudinal memory differences that we found between the SCD groups. This result is consistent with prior work suggesting that APOE ε4 positivity and SCD may have an additive effect on episodic memory decline [34].…”

Section: Discussionsupporting

confidence: 92%

Objective features of subjective cognitive decline in a United States national database

Kielb

Rogalskı

Weıntraub

et al. 2017

Alzheimer's & Dementia

View full text Add to dashboard Cite

INTRODUCTION Functional and cognitive features of subjective cognitive decline (SCD) were identified in a longitudinal database from the National Alzheimer Coordinating Center. METHODS Cognitively normal older adults with (SCD+) and without (SCD-) self-reported memory complaints (N=3915) were compared on 1) baseline Functional Assessment Questionnaire (FAQ) ratings, 2) baseline scores and longitudinal rate of change estimates from nine neuropsychological tests, and 3) final clinical diagnoses. RESULTS SCD+ had higher baseline ratings of functional impairment, reduced episodic memory practice effects and poorer performance on neuropsychological tests of psychomotor speed and language, and higher frequencies of mild cognitive impairment and dementia diagnoses at the end of follow-up compared to the SCD- group. DISCUSSION Subtle clinical features of SCD identified in this large cohort are difficult to detect at the individual level. More sensitive tests are needed to identify those with SCD who are vulnerable to cognitive decline and dementia.

show abstract

Section: Discussionsupporting

confidence: 92%

Objective features of subjective cognitive decline in a United States national database

Kielb

Rogalskı

Weıntraub

et al. 2017

Alzheimer's & Dementia

View full text Add to dashboard Cite

show abstract

“…We also found that cognitively intact APOE-ε4 carriers had significantly poorer performance on RAVLT indices than non-carriers, consistent with research showing poorer episodic memory performance during this clinically asymptomatic stage (El Haj et al, 2016; Twamley, Ropacki, & Bondi, 2006). …”

Section: Discussionsupporting

confidence: 88%

Motor timing intraindividual variability in amnestic mild cognitive impairment and cognitively intact elders at genetic risk for Alzheimer’s disease

Kay

Seidenberg

Durgerian

et al. 2017

Journal of Clinical and Experimental Neuropsychology

View full text Add to dashboard Cite

Introduction Intraindividual variability (IIV) in motor performance has been shown to predict future cognitive decline. The apolipoprotein E-epsilon 4 (APOE-ε4) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the APOE-ε4 allele on the performance of asymptomatic healthy elders in comparison to individuals with amnestic MCI (aMCI) on a fine motor synchronization, paced finger-tapping task (PFTT). Method Two Alzheimer’s disease (AD) risk groups, individuals with aMCI (n = 24) and cognitively intact APOE-ε4 carriers (n = 41), and a control group consisting of cognitively intact APOE-ε4 non-carriers (n = 65), completed the Rey Auditory Verbal Learning Test and the PFTT, which requires index finger tapping in synchrony with a visual stimulus (inter-stimulus interval = 333 milliseconds). Results Motor timing IIV, as reflected by the standard deviation of the inter-tap interval (ITI), was greater in the aMCI group relative to the two groups of cognitively intact elders; in contrast, all three groups had statistically equivalent mean ITI. No significant IIV differences were observed between the asymptomatic APOE-ε4 carriers and non-carriers. Poorer episodic memory performance was associated with greater IIV, particularly in the aMCI group. Conclusions Results suggest that increased IIV on a fine motor synchronization task is apparent in aMCI. This IIV measure was not sensitive in discriminating older asymptomatic individuals at genetic risk for AD from those without such a genetic risk. In contrast, episodic memory performance, a well-established predictor of cognitive decline in preclinical AD, was able to distinguish between the two cognitively intact groups based on genetic risk.

show abstract

“…The results of the impact of the APOE ‐ε4 carrier genotype on EM deficits have been inconsistent . In this study, we found a possible effect of APOE ‐ PICALM interactions on EM deficits, which have not been previously reported in patients with AD.…”

Section: Discussioncontrasting

confidence: 81%

Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease

Chang

Huang

et al. 2018

Genes Brain and Behavior

View full text Add to dashboard Cite

Metabolic connectivity as showed by [18F] fluorodeoxyglucose (FDG) positron emission tomography (FDG-PET) reflects neuronal connectivity. The aim of this study was to investigate the genetic impact on metabolic connectivity in default mode subnetworks and its clinical-pathological relationships in patients with Alzheimer's disease (AD). We separately investigated the modulation of 2 default mode subnetworks, as identified with independent component analysis, by comparing APOE-ε4 carriers to noncarriers with AD. We further analyzed the interaction effects of APOE (APOE-ε4 carriers vs noncarriers) with PICALM (rs3851179-GG vs rs3851179-A-allele carriers) on episodic memory (EM) deficits, reduction in cerebral metabolic rate for glucose (CMRgl) and decreased metabolic connectivity in default mode subnetworks. The metabolic connectivity in the ventral default mode network (vDMN) was positively correlated with EM scores (β =0.441, P < .001). The APOE-ε4 carriers had significantly lower metabolic connectivity in the vDMN than the APOE-ε4 carriers (t(96) = -2.233, P = .028). There was an effect of the APOE-PICALM (rs3851179) interactions on reduced CMRgl in regions of vDMN (P < .001), and on memory deficits (F =5.568, P = .020). This study identified that PICALM may modulates memory deficits, reduced CMRgl and decreased metabolic connectivity in the vDMN in APOE-ε4 carriers. [18F] FDG-PET-based metabolic connectivity may serve a useful tool to elucidate the neural networks underlying clinical-pathological relationships in AD.

show abstract

Apolipoprotein E (APOE) ε4 and episodic memory decline in Alzheimer’s disease: A review

Cited by 75 publications

References 158 publications

Objective features of subjective cognitive decline in a United States national database

Objective features of subjective cognitive decline in a United States national database

Motor timing intraindividual variability in amnestic mild cognitive impairment and cognitively intact elders at genetic risk for Alzheimer’s disease

Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease

Contact Info

Product

Resources

About