Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly

Abstract

Independently from B vitamin status, APOE4 carriers have a lower risk of hyperhomocysteinemia and of high CRP than do noncarriers, but the presence of one condition attenuates the association of APOE4 with the other condition.

Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in patients on long-term hemodialysis

“…These results are inconsistent with the findings reported by Ravaglia et al, who demonstrated that elderly patients who are apoe4 carriers exhibit a lower risk of hyperhomocysteinemia and higher CRP than those who are not carriers of the apoe4 genotype. 35 Thus, because of the few number of studies on the apoE gene that enrolled ESRD patients on hemodialysis, the examination of inflammation with respect to the apoE gene polymorphism requires a large cohort of patients, and several investigations are necessary to confirm these findings.…”

KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Patients

“…The nonsignificant interaction between KIF6 and ApoE on tHcy suggests that the association between KIF6 and tHcy is independent of ApoE. The importance of this finding is highlighted by previous studies demonstrating associations between ApoE and tHcy [28, 41] and suggests that KIF6 might be involved in AD-related cardiovascular pathways that are independent of those associated with ApoE.…”

“…Haan et al [27] found that ApoE ε 4 carriers had significantly lower CRP levels than noncarriers and that higher CRP levels were associated with a decreased risk of incident all-cause CIND/dementia among ApoE ε 4 carriers [OR = 0.60; 95% CI (0.20, 0.91) P = 0.03]. Among cognitively normal older adults, Ravaglia et al [28] found that ApoE ε 4 carriers with normal CRP levels had a significantly lower risk of elevated tHcy levels [OR = 0.22; 95% CI (0.08, 0.59)] and were less likely to have elevated CRP levels in the presence of normal tHcy levels [OR = 0.51; 95% CI (0.31, 0.85)] when compared to noncarriers.…”

Plasma homocysteine, apolipoprotein E status and vascular disease in elderly patients with mental illness

“…Those investigations, however, did not focus specifically on the association of interest, and two (39,40) had small population sizes. In a recent study (42), APOE4 carriers in an elderly healthy population had an even lower risk of hyperhomocysteinemia than did non-carriers, but only if the carriers did not have increased CRP concentrations. The authors (42) suggested that this finding could possibly be attributed to CRP and plasma tHcy competing for the same mechanism (perhaps a lipoprotein carrier) that favours their clearance from blood in APOE4 carriers.…”

“…In a recent study (42), APOE4 carriers in an elderly healthy population had an even lower risk of hyperhomocysteinemia than did non-carriers, but only if the carriers did not have increased CRP concentrations. The authors (42) suggested that this finding could possibly be attributed to CRP and plasma tHcy competing for the same mechanism (perhaps a lipoprotein carrier) that favours their clearance from blood in APOE4 carriers. However, in a small subpopulation of the present study population we could observe no such association between APOE4 carrier status and concentrations of plasma tHcy and serum CRP.…”