Apolipoprotein E Effects on Mammalian Ovarian Steroidogenesis and Human Fertility

Oriá, Reinaldo B.; Almeida, Juliana Zani de; Moreira, Carolyne Neves; Guerrant, Richard L.; Figueiredo, J.R.

doi:10.1016/j.tem.2020.06.003

Cited by 29 publications

(28 citation statements)

References 69 publications

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“…Several studies point to the effects of fetal programming and maternal and environmental factors during early life on the development of diseases in adulthood (11)(12)(13)(14)(15)(16). Maternal nutrition even before pregnancy can affect the development of the fetus with later risk for cardiovascular/metabolic diseases (12).…”

Section: Impact Of Nutritional Transition In Developing Countriesmentioning

confidence: 99%

“…In women, early childhood undernutrition increases the risk of complications in childbirth later in life (13). In countries with poor sanitary conditions, the occurrence of the APOE4, a recognized gene associated with increased risk for acquiring Alzheimer's disease, may favor maternal fertility and promote protection against childhood diarrhea, while possibly increasing the risk of NCD with aging (14). In animal models, maternal obesity affects leptin mRNA expression and its peak in offspring (15).…”

Section: Impact Of Nutritional Transition In Developing Countriesmentioning

confidence: 99%

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The Transition From Undernutrition to Overnutrition Under Adverse Environments and Poverty: The Risk for Chronic Diseases

et al. 2021

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Section: Impact Of Nutritional Transition In Developing Countriesmentioning

confidence: 99%

Section: Impact Of Nutritional Transition In Developing Countriesmentioning

confidence: 99%

The Transition From Undernutrition to Overnutrition Under Adverse Environments and Poverty: The Risk for Chronic Diseases

et al. 2021

Self Cite

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“…ApoE is implicated in cholesterol transport within ovarian follicles to regulate steroidogenesis, and may deliver lipoprotein-derived cholesterol to follicle cells during androgen synthesis, thereby regulating women's reproductive function. The second role of ApoE in ovarian tissue is the downregulation of androgens by theca cells to favor progesterone synthesis [31]. Oriá et al [31] also reported that the increase of ApoE concentration in follicular fluid correlated with a decrease in fertility with age.…”

Section: Apoe In Female Fertilitymentioning

confidence: 99%

“…The second role of ApoE in ovarian tissue is the downregulation of androgens by theca cells to favor progesterone synthesis [31]. Oriá et al [31] also reported that the increase of ApoE concentration in follicular fluid correlated with a decrease in fertility with age.…”

Section: Apoe In Female Fertilitymentioning

confidence: 99%

“…Its adverse associations in affluent modern societies with later onset diseases of aging further characterize ApoEε4 as an example of antagonistic pleiotropy [33]. Accumulating evidence indicates a dual effect of ApoEε4 during the lifespan, being beneficial to women's fertility, but detrimental to late-life chronic diseases, only in settings of poor hygiene and sanitation [31]. The ApoE also could influence reproduction through involvement in the embryo development, as indicated by the reported association of the ApoE gene with trisomies 13, 18, and 21 [34].…”

Section: Apoe In Female Fertilitymentioning

confidence: 99%

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The Role of ApoE Expression and Variability of Its Glycosylation in Human Reproductive Health in the Light of Current Information

Kacperczyk

Kmieciak

Kratz

2021

IJMS

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Apolipoprotein E (ApoE), a 34-kDa glycoprotein, as part of the high-density lipoprotein (HDL), has antioxidant, anti-inflammatory and antiatherogenic properties. The variability of ApoE expression in the course of some female fertility disorders (endometriosis, POCS), and other gynecological pathologies such as breast cancer, choriocarcinoma, endometrial adenocarcinoma/hyperplasia and ovarian cancer confirm the multidirectional biological function of ApoE, but the mechanisms of its action are not fully understood. It is also worth taking a closer look at the associations between ApoE expression, the type of its genotype and male fertility disorders. Another important issue is the variability of ApoE glycosylation. It is documented that the profile and degree of ApoE glycosylation varies depending on where it occurs, the type of body fluid and the place of its synthesis in the human body. Alterations in ApoE glycosylation have been observed in the course of diseases such as preeclampsia or breast cancer, but little is known about the characteristics of ApoE glycans analyzed in human seminal and blood serum/plasma in the context of male reproductive health. A deeper analysis of ApoE glycosylation in the context of female and male fertility will both enable us to broaden our knowledge of the biochemical and cellular mechanisms in which glycans participate, having a direct or indirect relationship with the fertilization process, and also give us a chance of contributing to the enrichment of the diagnostic panel in infertile women and men, which is particularly important in procedures involved in assisted reproductive techniques. Moreover, understanding the mechanisms of glycoprotein glycosylation related to the course of various diseases and conditions, including infertility, and the interactions between glycans and their specific ligands may provide us with an opportunity to interfere with their course and thus develop new therapeutic strategies. This brief overview details some of the recent advances, mainly from the last decade, in understanding the associations between ApoE expression and some female and male fertility problems, as well as selected female gynecological diseases and male reproductive tract disorders. We were also interested in how ApoE glycosylation changes influence biological processes in the human body, with special attention to human fertility.

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Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2‐Foxo1‐GSH‐NF‐κB pathway

Jin,

Wang,

Huang

et al. 2024

Cell Biology International

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Polycystic ovary syndrome (PCOS) is the primary cause of female infertility with a lack of universal therapeutic regimen. Although osthole exhibits numerous pharmacological activities in treating various diseases, its therapeutic effect on PCOS is undiscovered. The present study found that application of osthole improved the symptoms of PCOS mice through preventing ovarian granulosa cells (GCs) production of more estrogen and alleviating the liberation of pro‐inflammatory cytokine interleukin (IL)‐1β, IL‐6, and tumor necrosis factor alpha. Meanwhile, osthole enhanced ovarian antioxidant capacity and alleviated intracellular reactive oxygen species (ROS) accumulation with a concurrent attenuation for oxidative stress, while intervention of antioxidant enzymic activity and glutathione (GSH) synthesis neutralized the salvation of osthole on GCs secretory disorder and chronic inflammation. Further analysis revealed that osthole restored the expression of nuclear factor erythroid 2‐related factor 2 (Nrf2) and forkhead box O 1 (Foxo1) whose repression antagonized the amelioration of osthole on the insufficiency of antioxidant capacity and accumulation of ROS. Moreover, Nrf2 served as an intermedium to mediate the regulation of osthole on Foxo1. Additionally, osthole restricted the phosphorylation of IκBα and nuclear factor kappa B (NF‐κB) subunit p65 by DHEA and weakened the transcriptional activity of NF‐κB, but this effectiveness was abrogated by the obstruction of Nrf2 and Foxo1, whereas adjunction of GSH renewed the redemptive effect of osthole on NF‐κB whose activation caused an invalidation of osthole in rescuing the aberration of GCs secretory function and inflammation response. Collectively, osthole might relieve the symptoms of PCOS mice via Nrf2‐Foxo1‐GSH‐NF‐κB pathway.

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Apolipoprotein E Effects on Mammalian Ovarian Steroidogenesis and Human Fertility

Cited by 29 publications

References 69 publications

The Transition From Undernutrition to Overnutrition Under Adverse Environments and Poverty: The Risk for Chronic Diseases

The Transition From Undernutrition to Overnutrition Under Adverse Environments and Poverty: The Risk for Chronic Diseases

The Role of ApoE Expression and Variability of Its Glycosylation in Human Reproductive Health in the Light of Current Information

Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2‐Foxo1‐GSH‐NF‐κB pathway

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