Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis

Zurnic, Irena; Djurić, Tamara; Končar, Igor; Stanković, Aleksandra; Dinčić, Dragan; Živković, Maja

doi:10.2298/vsp1404362z

Cited by 6 publications

(10 citation statements)

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“…According to previous reports [ 37 , 38 , 39 , 40 ], the pathogeneses of NAFLD and atherosclerosis are both closely related to an imbalance of lipid metabolism. To explore the possible mechanism underlying the effectiveness of xyloketal B treatment of NAFLD, we investigated the effects of xyloketal B on lipid metabolism, mainly focusing on liver fatty acid synthesis and clearance pathways in vivo and in vitro.…”

Section: Discussionmentioning

confidence: 99%

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models

et al. 2017

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Abstract:The goal of this study was to examine the effects of xyloketal B on nonalcoholic fatty liver disease (NAFLD) and to explore the molecular mechanisms underlying its effects in both in vivo and in vitro models. We discovered an association between xyloketal B and the sterol regulatory element-binding protein-1c (SREBP-1c) signaling pathway, which is related to lipid metabolism. Mice were dosed with xyloketal B (5, 10 and 20 mg/kg/d) and atorvastatin (15 mg/kg/d) via intraperitoneal injection once daily for 40 days after being fed a high fat diet plus 10% high fructose liquid (HFD+HFL) for 8 weeks. Xyloketal B significantly improved HFD+HFL-induced hepatic histological lesions and attenuated lipid and glucose accumulation in the blood as well as lipid accumulation in the liver. Xyloketal B increased the expression of CPT1A, and decreased the expression of SREBP-1c and its downstream targeting enzymes such as ACC1, ACL, and FAS. Xyloketal B also significantly reduced lipid accumulation in HepG2 cells treated with free fatty acids (FFAs). These data suggested that xyloketal B has lipid-lowering effects via the SREBP-1c pathway that regulate lipid metabolism. Thus, targeting SREBP-1c activation with xyloketal B may be a promising novel approach for NAFLD treatment.

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Section: Discussionmentioning

confidence: 99%

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models

et al. 2017

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“…ApoE can transport cholesterol and regulate lipid metabolism, and has become the focal point of recent studies (Al Harthi et al, 2014;Berkinbayev et al, 2014;Zurnić et al, 2014). In recent years, as the development of molecular biology and genetic engineering technologies has progressed, studies have demonstrated a close association between the ApoE gene polymorphism and serum lipid levels (Shin et al, 2014;Yin et al, 2014;Zhu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

et al. 2015

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ABSTRACT. The aim of this study was to explore the relationship between the ApoE gene polymorphism and dietary factors with stroke and circulating lipid levels in the Chinese population. We selected 580 patients with stroke and 580 age-and gender-matched healthy controls, and examined their ApoE polymorphism genotype using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We also analyzed the relationship between the ApoE gene polymorphism and dietary factors as well as plasma lipid concentrations in this cohort. We detected six ApoE genotypes in the study populations, and determined that the E4 allele was positively associated with cerebral infarction (CI), whereas allele E2 was negatively associated with total cholesterol (TC) and low-density lipoprotein-cholesterol levels. The dietary habits of the subjects with descending order of average total TC and triglyceride levels were: subjects addicted to oily food > subjects addicted to sweets > subjects addicted to smoking > subjects addicted to alcohol > subjects following a vegetarian diet (P < 0.05). Our results demonstrated that the ApoE gene polymorphism was associated with a risk for CI in a Chinese population.

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“…In total, there were 36,245 subjects (sample size ranging from 75 to 19,201) with 15,285 (42.2%) males and 20,960 (57.8%) female subjects. Geographically, three studies were conducted in the United States ( 13 , 24 , 25 ), two in Spain ( 16 , 26 ), one each in Japan ( 27 ), Australia ( 12 ), Poland ( 28 ), France ( 5 ), Taiwan ( 29 ), Turkey ( 30 ), Finland ( 31 ), Korea ( 32 ), the Netherlands ( 33 ), Greece ( 34 ), Italy ( 35 ), and Serbia ( 36 ). The majority were single-center studies, with three conducted at multiple sites ( 5 , 25 , 32 ).…”

Section: Resultsmentioning

confidence: 99%

“…The majority were single-center studies, with three conducted at multiple sites ( 5 , 25 , 32 ). Six studies drew subjects from population samples ( 5 , 12 , 26 , 29 , 32 , 33 ) and the remaining studies evaluated specific populations including 1 study that sampled patients with coronary disease ( 16 ), one examined subjects after carotid endarterectomy ( 36 ), one looked at patients with chronic kidney disease on hemodialysis ( 27 ), one included post-transplant individuals ( 30 ), one with patients with ischemic stroke within seven days of onset ( 28 ), two evaluated males with hypertension ( 24 , 31 ), one had families with higher-than-expected rates of coronary heart disease ( 25 ), one enrolled menopausal women ( 34 ), and one examined mildly cognitively impaired individuals ( 35 ). Of the 17 studies in the systematic analysis, 10 were eligible for meta-analysis ( 5 , 12 , 13 , 16 , 25 – 27 , 29 , 32 , 33 ).…”

Section: Resultsmentioning

confidence: 99%

Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis

Culleton,

Niu,

Alexander

et al. 2023

Front. Cardiovasc. Med.

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IntroductionCarotid atherosclerotic plaque is an important independent risk factor for stroke. Apolipoprotein E (APOE) influences cholesterol levels and certain isoforms are associated with increased carotid atherosclerosis, though the exact association between APOE and carotid plaque is uncertain. The study aimed to evaluate the association between APOE and carotid plaque.MethodsA systematic review was performed to retrieve all studies which examined the association between carotid plaque and APOE. This study was conducted in accordance with the PRISMA guidelines. Independent readers extracted the relevant data from each study including the type of imaging assessment, plaque definition, frequency of APOE E4 carrier status and type of genotyping. Meta-analyses with an assessment of study heterogeneity and publication bias were performed. Results were presented in a forest plot and summarized using a random-effects model.ResultsAfter screening 838 studies, 17 studies were included for systematic review. A meta-analysis of 5 published studies showed a significant association between ε4 homozygosity and carotid plaque [odds ratio (OR), 1.53; 95% CI, 1.16, 2.02; p = .003]. Additionally, there was a significant association between patients possessing at least one ε4 allele, heterozygotes or homozygotes, and carotid plaque (OR, 1.25; 95% CI, 1.03, 1.52; p = .03). Lastly, there was no association between ε4 heterozygosity and carotid plaque (OR, 1.08; 95% CI, 0.93, 1.26; p = .30).ConclusionAPOE ε4 allele is significantly associated with extracranial carotid atherosclerotic plaque, especially for homozygous individuals.

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Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis

Cited by 6 publications

References 0 publications

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models

Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis

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