2019
DOI: 10.1096/fasebj.2019.33.1_supplement.731.10
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Apolipoprotein E modulates respiratory motor plasticity following cervical spinal cord injury

Abstract: Each year, 17,700 Americans suffer a spinal cord injury, over half of which occur at the cervical level. These high level injuries can interrupt bulbospinal neurons that innervate the phrenic motornucleus, the origin of the phrenic nerve. Loss of these descending inputs to the phrenic nerve paralyzes the ipsilateral diaphragm, leading to breathing impairments. One approach to promote recovery of breathing function is by enhancing plasticity through strengthening of synapses or activating spared but latent path… Show more

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