Apolipoprotein E

Carrasquillo, Minerva M.; Bu, Guojun; Nielsen, Henrietta M.

doi:10.1007/978-1-4614-7309-1_2

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2017

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“…AD is a heterogeneous disease, and about 70 % of the risk is believed to be genetic with many genes involved (Karch et al, 2014[ 24 ]). The APOE gene that encodes apolipoprotein E (ApoE) located on human chromosome 19 is a multifunctional protein and is a major cholesterol carrier with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases (Carrasquillo et al, 2013[ 11 ]; Hatters et al, 2006[ 20 ]). The APOE gene has been recognized as a possible genetic risk factor for the onset of AD (Yu et al, 2014[ 60 ]).…”

Section: Introductionmentioning

confidence: 99%