Apolipoprotein E polymorphism in the Greek population

Sklavounou, E.; Economou-Petersen, Effrosini; Karadima, Georgia; Πάνας, Μάριος; Avramopoulos, Dimitris; Varsou, Angeliki; Vassilopoulos, Dimitris; Petersen, Michael B.

doi:10.1111/j.1399-0004.1997.tb02550.x

Cited by 44 publications

(7 citation statements)

References 26 publications

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“…Data on APOE allele frequencies collected from literature showed that the APOE allele distributions were different between North and South Europe. Additionally, compared to northern European countries, Mediterranean countries such as Italy, Turkey and Greece had lower frequencies of APOE-ε2 and ε4 alleles [77][78][79].…”

Section: Discussionmentioning

confidence: 91%

The Role of Apolipoprotein E Gene Polymorphisms in Primary Glaucoma and Pseudoexfoliation Syndrome

Dabbagh¹,

Al-Saleh²,

Dohayan³

et al. 2013

Glaucoma - Basic and Clinical Aspects

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Section: Discussionmentioning

confidence: 91%

The Role of Apolipoprotein E Gene Polymorphisms in Primary Glaucoma and Pseudoexfoliation Syndrome

Dabbagh¹,

Al-Saleh²,

Dohayan³

et al. 2013

Glaucoma - Basic and Clinical Aspects

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“…The frequency of the ϵ4 allele in Europe parallels the incidence of CHD and other diseases [ 11 , 30 , 31 ]. It follows a north-to-south gradient and ranges from more than 0.22 in Finland and Greenland [ 32 - 34 ] to less than 0.07 in Greece and Italy [ 35 - 37 ]. In our study, the ϵ4 allele frequency (0.10) was similar to values observed in other North African populations (around 0.10 in Moroccan populations [ 26 , 38 ] and around 0.08 in Tunisian populations [ 27 , 28 ]).…”

Section: Discussionmentioning

confidence: 99%

Impact of APOE gene polymorphisms on the lipid profile in an Algerian population

et al. 2013

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BackgroundThe importance of apolipoprotein E (APOE) in lipid and lipoprotein metabolism is well established. However, the impact of APOE polymorphisms has never been investigated in an Algerian population. This study assessed, for the fist time, the relationships between three APOE polymorphisms (epsilon, rs439401, rs4420638) and plasma lipid concentrations in a general population sample from Algeria.MethodsThe association analysis was performed in the ISOR study, a representative sample of the population living in Oran (787 subjects aged between 30 and 64). Polymorphisms were considered both individually and as haplotypes.ResultsIn the ISOR sample, APOE ϵ4 allele carriers had higher plasma triglyceride (p=0.0002), total cholesterol (p=0.009) and LDL-cholesterol (p=0.003) levels than ϵ3 allele carriers. No significant associations were detected for the rs4420638 and rs439401 SNPs. Linkage disequilibrium and haplotype analyses confirmed the respectively deleterious and protective impacts of the ϵ4 and ϵ2 alleles on LDL-cholesterol levels and showed that the G allele of the rs4420638 polymorphism may exert a protective effect on LDL-cholesterol levels in subjects bearing the APOE epsilon 4 allele.ConclusionOur results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the ϵ4 allele on LDL-cholesterol levels in an Algerian population.

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“…The ApoE3 allele is the most common allele in each population [34]. The ApoE3 allele showed a significantly higher frequency in the PCOS patient group when compared with the control group (p<0.001).…”

Section: Discussionmentioning

confidence: 92%

Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey

Çetinkalp

Karadeniz

Erdoğan

et al. 2008

J Assist Reprod Genet

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Purpose Dyslipidemia, cardiovascular disease and hypertension are more frequently seen in patients with PCOS than in normal patients. We aimed at evaluating the distribution of Apo E alleles that can influence cardiovascular risk of the PCOS patients and control subjects. Methods In this study, 129 young women with PCOS and 91 healthy women were included. In all subjects we performed hormonal, biochemical and Apo E genetic analysis. Results The Apo E3 allele was found at a significantly higher frequency in the PCOS patient group compared with the control group. The Apo E2 allele was found at a significantly higher frequency in the control group compared with the patient group with PCOS. Conclusions Although there were genotype and allele differences between control and patient groups in this study, no statistically significant change was determined in lipid and other cardiovascular risk factors in connection with allele and genotype.

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Apolipoprotein E polymorphism in the Greek population

Cited by 44 publications

References 26 publications

The Role of Apolipoprotein E Gene Polymorphisms in Primary Glaucoma and Pseudoexfoliation Syndrome

The Role of Apolipoprotein E Gene Polymorphisms in Primary Glaucoma and Pseudoexfoliation Syndrome

Impact of APOE gene polymorphisms on the lipid profile in an Algerian population

Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey

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