Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4

Muros, Mercedes; Rodríguez-Ferrer, Carmen R.

doi:10.1016/0021-9150(95)06643-8

Cited by 83 publications

(42 citation statements)

References 29 publications

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“…The distribution of the apo E genotypes did not differ between girls and boys, and was similar to that reported in South European countries (17,18). Mean values for anthropometric variables were similar across apo E genotypes (data not shown).…”

Section: Resultssupporting

confidence: 82%

Influence of Birth Weight on the Apo E Genetic Determinants of Plasma Lipid Levels in Children

et al. 2002

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To evaluate the influence of birth weight on apolipoprotein (apo) E genetic determinants of plasma lipids levels in prepubertal children we studied 933 healthy children (491 males and 442 females) 6 to 8 years old (mean age of 6.7 y), whose weight was recorded at birth. Plasma lipid and apolipoprotein concentrations and apo E genotypes were determined. We observed a greater effect of the apo E polymorphism on total cholesterol (TC), LDL-cholesterol (LDL-C) and especially apo B levels in children with birth weight in the lower tertile compared with those with birth weights in higher tertiles. Taking the ⑀3 allele homozygosity as reference, in boys with birth weights in the low tertile the overall lowering effect of the ⑀2 allele on TC, LDL-C and apo B was greater (10.5% (p Ͻ 0.01), 20.2% (p Ͻ 0.01) and 18.8% (p Ͻ 0.01), respectively) than in those in the highest tertile (5.6% on TC, 10.3% on LDL-C and 12.6% (p Ͻ 0.01) on apo B). A similar trend in this effect between tertiles of birth weight was also observed in girls. For both sexes, linear regression analysis demonstrates a positive and significant interaction between birth weight and ⑀2, which may explain the fact that the decrease in TC, LDL-C and apo B associated with the ⑀2 allele is more marked the lower the birth weight. Taking into account the prevalence of apo E polymorphism, and that appears to be the main genetic factor affecting plasma lipids, the interaction of apo E genotype and birth weight could be an important determinant of TC, LDL-C and apo B levels, and, as a consequence, of atherosclerosis. (Pediatr Res 52: 873-878, 2002) Abbreviations apo, apolipoprotein TC, total cholesterol TG, triglycerides HDL-C, HDL-cholesterol LDL-C, LDL-cholesterol CHD, coronary heart disease Coronary heart disease (CHD) and its risk factors, including abnormalities in lipid metabolism, are associated with small size at birth and low weight during infancy (1, 2). Genetic composition also determines differences in plasma lipid levels and susceptibility to atherosclerosis. Although the risk of CHD due to both environmental and genetic influences is well known, the extent of interactions between these factors has not been well characterized.Apolipoprotein E (apo E) is one of the key regulators of plasma lipid levels by affecting the hepatic binding, uptake, and catabolism of several classes of lipoproteins (3). Apo E genotypes are one of the most important genetic determinants of atherogenesis. Apo E appears in three isoforms E2, E3, and E4, encoded by the corresponding alleles ⑀2, ⑀3, and ⑀4. Previous studies have documented the impact of these mutations on CHD (4 -6) and the effects of these alleles on the normal variation of lipid levels in adult populations. Heterozygous subjects for the ⑀2 and ⑀4 alleles had, respectively, lower and higher total cholesterol (TC) and LDL-C levels than subjects carrying the ⑀3⑀3 genotype (7-9). This influence of the apo E polymorphisms on the metabolism of the apo B-containing lipoproteins appears to be present in the 1st years of li...

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Section: Resultssupporting

confidence: 82%

Influence of Birth Weight on the Apo E Genetic Determinants of Plasma Lipid Levels in Children

et al. 2002

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“…Furthermore, we found that apoE genotypes influenced Lp[a] levels in African Americans but not in Caucasians; African American subjects with the apo E2 genotype had lower Lp[a] levels compared with apo e3 or e4 carriers. Previous studies investigating the influence of apoE gene variation on Lp[a] levels have shown contradictory results, although the reasons for these differences have not been clarified (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). Most of these studies have been carried out in Caucasians, and furthermore, total Lp[a] levels have been assessed.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies have investigated the impact of apoE genotypes on Lp[a] levels, but the results have been contradictory. Thus, no impact of apoE genotypes on Lp[a] levels were reported in several studies (24)(25)(26)(27)(28)(29)(30), whereas others reported significant differences in plasma Lp[a] levels across apoE phenotypes (31)(32)(33)(34)(35)(36) …”

mentioning

confidence: 99%

ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study

Anuurad

Rubin

et al. 2007

Journal of Lipid Research

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The genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher lipoprotein [a] (15,18,19). Furthermore, as described above, we and others have identified several genetic variations that affect allele-specific apo[a] levels (8,16,17,20). Genetic variability of apolipoprotein E (apoE) is a major determinant of plasma lipoprotein levels (21), and furthermore, apoE genotype frequencies differ between African Americans and Caucasians (22,23). As the African AmericanCaucasian differences in allele-specific apo[a] levels for large apo[a] sizes remain unexplained, we focused on apoE as a possible genetic factor potentially contributing to this difference. Earlier studies have investigated the impact of apoE genotypes on Lp[a] levels, but the results have been

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“…E*2 has been associated with higher levels (5,23,35,(38)(39)(40) and lower levels (6,33) relative to E*3 and E*4. Our study shows higher triglyceride concentrations in E*4 carriers than in E*2 carriers.…”

Section: Discussionmentioning

confidence: 99%

Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population

de-Andrade

Larrandaburu

Callegari-Jacques

et al. 2000

Braz J Med Biol Res

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Apolipoprotein E (protein: apo E; gene: APOE) plays an important role in the multifactorial etiology of both Alzheimers disease (AD) and lipid level concentrations. The polymerase chain reaction (PCR) was used to investigate the APOE gene polymorphism in 446 unrelated Caucasians, among them 23 AD patients, and 100 Afro-Brazilians living in Porto Alegre, Brazil. The frequencies of the APOE*2, APOE*3 and APOE*4 alleles were 0.075, 0.810 and 0.115 in Caucasians and 0.075, 0.700 and 0.225 in Afro-Brazilians, respectively (c 2 = 8.72, P = 0.013). A highly significant association was observed between the APOE*4 allele and AD in this population-based sample. The APOE*4 frequency in AD patients (39%) was about four times higher than in the general Caucasian population (11.5%). The influence of each of the three common APOE alleles on lipid traits was evaluated by the use of the average excess statistic. The E*2 allele is associated with lower levels of triglycerides and of total and non-HDL cholesterol in both men and women. Conversely, the E*4 allele is associated with higher levels of these traits in women only. The effect of APOE alleles was of greater magnitude in women.

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Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4

Cited by 83 publications

References 29 publications

Influence of Birth Weight on the Apo E Genetic Determinants of Plasma Lipid Levels in Children

Influence of Birth Weight on the Apo E Genetic Determinants of Plasma Lipid Levels in Children

ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Study

Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population

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