Apolipoprotein E polymorphism is associated with lower extremity deep venous thrombosis: color-flow Doppler ultrasound evaluation

Zhu, Shuangli; Wang, Zhigang; Wu, Xiaoping; Su, Yan; Lu, DunXiang

doi:10.1186/1476-511x-13-21

Cited by 29 publications

(27 citation statements)

References 43 publications

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“…We did not find a significant association between Triglycerides plasma level and the risk of VTE, also the two studies of Kawasaki et al [11], Inge Van Schouwenburg et al [12], Everett [14] and Zamani have confirmed our finding [15][16][17][18][19][20][21][22][23][24][25][26][27][28], however, Carine Doggen et al [13], Amparo Vaya et al [6], Joel Ray et al [28] and Anders Holst [7] found a significant higher levels in patients.…”

Section: Patients (Mean ± Et) Controls (Mean ± Et) P Valuesupporting

confidence: 86%

“…The difference in the Apo B/Apo A1 ratio between VTE patients and controls was statistically stronger, our results are consistent with Hiroshi Deguchi et al [19] but Amparo Vaya [6] show that Apo B/Apo A1 ratio is not a risk factor for venous thrombosembolism. We did not observe a significant difference in Apo E levels between patients and controls, and the few studies Jose Diaz [29] et al and Shuang Li Zhue [26] addressing this issue have failed to demonstrate a link between Apo E and VTE. When dichotomized into higher or lower than 0.91 mmol/l HDL-C groups, we found a significant association between HDL-C≤0.91 mmol/l in patients groups, this finding is confirmed by the Spanish study of Garcia Raso et al [27] but in contrast with him when we regard LDL-C above 4.66 mmol/L.…”

Section: Patients (Mean ± Et) Controls (Mean ± Et) P Valuecontrasting

confidence: 75%

“…Statistically significant P value were found for VTE associated with elevated Apo B concentration and with concentration decrease of Apo A1 were observed in patients when compared with controls, our finding is confirmed for both Apo A1 and Apo B in Hiroshi Deguchi et al study [19] but Sabine Eichinger et al [16] and Marcial Martinez [5] have uphold this significant association only for Apo A, however, Alanna chamberlain et al [25] did not find this significant association. Also in a recent study by Inge Van Schowenberg et al [12] did not show a significant association of Apo B with VTE [26][27][28].…”

Section: Patients (Mean ± Et) Controls (Mean ± Et) P Valuementioning

confidence: 99%

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The Association between Venous Thromboembolism and Lipid Profile in a Tunisian Population

A¹,

Denguir²

2016

Vasc Med Surg

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Background and objectives: Lipids and lipoproteins modulate the expression and/or the function of thrombotic, fibrinolytic and rheological factors among patients with cardiovascular disease. Many studies have suggested a link between risk factors of venous thromboembolism (VTE) and dyslipidemia but results are heterogeneous. We sought to identify if dyslipidemia is a risk factor of VTE disease. Patients and methods: We have developed an hospital-based case-control study which was conducted in 32 patients with VTE and 33 age-and gender-matched healthy controls. We were proceeding to compare the lipid profile of the two groups after analysing the total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Lipoprotein Lp(a), Apo-A1, Apo-B and Apo-E. Patients who have cancer and whose taken statins or fibrates are excluded. Results: The two groups have the same demographic characteristics but there were more diabetics, arterial hypertension and obese in the VTE group than the control group respectively (Diabetic: 37% vs. 18%, hypertension: 68.6% vs. 15.2% and (body mass index) BMI ≥30 Kg/m 2 : 43.8% vs. 18.2%). The mean value of the total cholesterol (TC), the LDL-C, Lipoprotein Lp (a), and Apo-B were statistically higher in the VTE group compared to control group respectively ; TC (4.942 ± 1.409 vs. 4.362 ± 0.872 mmol/L,P=0.049), LDL-C (3.114 ± 1.100 vs. 2.602 ± 0.695 mmol/L, P=0.001), Lp (a) (0.205 ± 0.115 vs. 0.0819 ± 0.0479 g/l, P <10-3), Apo-B (1.333 ± 0.253 vs. 0.8006 ± 0.238 g/l, P<10-3), but there was no statistical significant difference was observed between the two groups in the value of Triglycerides and Apo E respectively (1.710 ± 0.816 vs. 1.366 ± 0.636 mmol/L, P=0.62), (0.102 ± 0.070 vs. 0.0810 ± 0.153 g/l, P=0.48). However, the mean value of HDL-C and Apo-A1 were statically lower in the VTE group; HDL-C (1.048 ± 0.237 vs. 1.473 ± 0.334 mmol/L, P<0.001) and Apo-A1 (1.010 ± 0.2437 vs. 1.414 ± 0.2911 g/l, P<10-3). Furthermore, enhanced HDL-C ≤0.906 mmol/L was diagnosed in 21 patients (65.6%) in the VTE group versus 4 patients (12.1%) in the control group (P<0.001), so it was also independently associated with a risk of VTE. Conclusion: The present study shows a significant association between the occurrence of venous thromboembolism and lower levels of HDL-C and ApoA1 and higher levels of LDL-C, Apo-B and Lp(a), but, there were no effect of Triglycerides and ApoE. Nevertheless, these results must be confirmed with a large population study to prove an eventual independent factor for VTE and dyslipidemia.

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Section: Patients (Mean ± Et) Controls (Mean ± Et) P Valuesupporting

confidence: 86%

Section: Patients (Mean ± Et) Controls (Mean ± Et) P Valuecontrasting

confidence: 75%

Section: Patients (Mean ± Et) Controls (Mean ± Et) P Valuementioning

confidence: 99%

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The Association between Venous Thromboembolism and Lipid Profile in a Tunisian Population

A¹,

Denguir²

2016

Vasc Med Surg

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“…ApoE can transport cholesterol and regulate lipid metabolism, and has become the focal point of recent studies (Al Harthi et al, 2014;Berkinbayev et al, 2014;Zurnić et al, 2014). In recent years, as the development of molecular biology and genetic engineering technologies has progressed, studies have demonstrated a close association between the ApoE gene polymorphism and serum lipid levels (Shin et al, 2014;Yin et al, 2014;Zhu et al, 2014). It has also been found that dietary factors had some impact on blood lipids, and that this effect could be modified by receptor lipoprotein metabolism (Petkeviciene et al, 2012;Rudkowska et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

et al. 2015

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ABSTRACT. The aim of this study was to explore the relationship between the ApoE gene polymorphism and dietary factors with stroke and circulating lipid levels in the Chinese population. We selected 580 patients with stroke and 580 age-and gender-matched healthy controls, and examined their ApoE polymorphism genotype using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We also analyzed the relationship between the ApoE gene polymorphism and dietary factors as well as plasma lipid concentrations in this cohort. We detected six ApoE genotypes in the study populations, and determined that the E4 allele was positively associated with cerebral infarction (CI), whereas allele E2 was negatively associated with total cholesterol (TC) and low-density lipoprotein-cholesterol levels. The dietary habits of the subjects with descending order of average total TC and triglyceride levels were: subjects addicted to oily food > subjects addicted to sweets > subjects addicted to smoking > subjects addicted to alcohol > subjects following a vegetarian diet (P < 0.05). Our results demonstrated that the ApoE gene polymorphism was associated with a risk for CI in a Chinese population.

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“…Notably, CBF is lower in APOE ε4 carriers regardless of AD diagnosis (Kim et al 2013; Thambisetti et al 2010). In addition, APOE ε4 variant has been linked to venous thrombosis and flow abnormalities in lower extremities (Zhu et al 2014), although at the time of this writing, its effect on cerebral out-flow is not known.…”

Section: Introductionmentioning

confidence: 99%

Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants

et al. 2017

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Sufficient cerebral blood flow (CBF) and venous drainage are critical for normal brain function, and their alterations can affect brain aging. However, to date, most studies focused on arterial CBF (inflow) with little attention paid to the age differences in venous outflow. We measured extra-cerebral arterial and venous blood flow rates with phase-contrast MRI and assessed the influence of vascular risk factors and genetic polymorphisms (ACE insertion/deletion, COMT val158met, and APOEε4) in 73 adults (age 18-74 years). Advanced age, elevated vascular risk, ACE Deletion, and COMT met alleles were linked to lower in- and outflow, with no effects of APOE ε4 noted. Lower age-related CBF rate was unrelated to brain volume and was observed only in val homozygotes of COMTval158met. Thus, in a disease-free population, age differences in CBF may be notable only in persons with high vascular risk and carriers of genetic variants associated with vasoconstriction and lower dopamine availability. It remains to be established if treatments targeting alleviation of the mutable factors can improve the course of cerebrovascular aging in spite of the immutable genetic influence.

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Apolipoprotein E polymorphism is associated with lower extremity deep venous thrombosis: color-flow Doppler ultrasound evaluation

Cited by 29 publications

References 43 publications

The Association between Venous Thromboembolism and Lipid Profile in a Tunisian Population

The Association between Venous Thromboembolism and Lipid Profile in a Tunisian Population

Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants

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