1995
DOI: 10.1016/0304-3940(95)11480-k
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Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases

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Cited by 39 publications
(21 citation statements)
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“…Although there was an important Spanish immigration to Colombia in former centuries, the Colombian population today is relatively stable. APOE ε4 allele frecuencies are lower in European mediterranean countries (Italy, Spain and Greece) than in northern European studies 15,16 .…”
Section: Discussionmentioning
confidence: 78%
“…Although there was an important Spanish immigration to Colombia in former centuries, the Colombian population today is relatively stable. APOE ε4 allele frecuencies are lower in European mediterranean countries (Italy, Spain and Greece) than in northern European studies 15,16 .…”
Section: Discussionmentioning
confidence: 78%
“…Furthermore, the ApoE genotype distribution detected among individuals with FXTAS resembles those found among Spanish patients with AD (Table 3). 20 Contrary to what has been published for AD, 14 no association has been found between the presence of the ApoE ε4 allele and the age of disease onset. Although the sample size is small, to our knowledge and considering that FXTAS is a rare disease and still poorly recognized among specialists, the cohort herein studied corresponds to one of the largest Spanish cohorts ever published.…”
Section: Discussionmentioning
confidence: 83%
“…Adroer et al 20 The study was accomplished in compliance with the Hospital Clinic ethics committee. Written informed consent was obtained from all the subjects before their participation.…”
Section: Original Research Articlementioning
confidence: 99%
“…The prevalence of the APOE-ε4 allele, regardless of ethnic variation, is approximately 15% in controls and 40% in patients with late-onset AD (familial and sporadic) [4, 5]. However, there is no agreement regarding how APOE-ε4 affects the course of the disease.…”
Section: Introductionmentioning
confidence: 99%