Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

Guo, Zhen; Ripoll, Carla Valenzuela; Picataggi, Antonino; Rawnsley, David R.; Özcan, Mualla; Chirinos, Julio A.; Chendamarai, Ezhilarasi; Girardi, Amanda; Riehl, Terrence E.; Evie, Hosannah; Diab, Ahmed; Kovács, Attila; Hyrc, Krzysztof L.; Ma, Xiucui; Asnani, Aarti; Shewale, Swapnil V.; Scherrer‐Crosbie, Marielle; Cowart, L. Ashley; Parks, John S.; Zhao, Lei; Gordon, David; Ramírez‐Valle, Francisco; Margulies, Kenneth B.; Cappola, Thomas P.; Desai, Ankit A.; Pedersen, Lauren N.; Bergom, Carmen; Stitziel, Nathan O.; Rettig, Michael P.; DiPersio, John F.; Hajny, Stefan; Christoffersen, Christina; Diwan, Abhinav; Javaheri, Ali

doi:10.1016/j.jacbts.2022.09.010

Cited by 16 publications

(2 citation statements)

References 56 publications

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“…S1P has been reported to promote autophagy-linked lysosomal degradation [ 101 , 102 ]. Specifically, S1P plays a role in membrane transport, thus protecting the lysosomal structure and controlling lysosomal homeostasis [ 103 , 104 ]. Lack of S1P hampers this homeostasis, consequently impeding the merging of autophagosomes with lysosomes, resulting in fatal autophagy [ 105 ].…”

Section: Regulation Of Autophagy By S1pmentioning

confidence: 99%

The role of sphingosine-1-phosphate in autophagy and related disorders

Xiao,

Peng,

et al. 2023

Cell Death Discov.

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S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such as cell growth, movement, programmed cell death, self-degradation, cell specialization, aging, and immune system reactions. Autophagy is a meticulously controlled mechanism in which cells repurpose their elements to maintain cellular balance. There are five stages in autophagy: initiation, nucleation, elongation and maturation, fusion, and degradation. New research has provided insight into the complex connection between S1P and autophagy, uncovering their interaction in both normal and abnormal circumstances. Gaining knowledge about the regulatory mechanism of S1P signaling on autophagy can offer a valuable understanding of its function in well-being and illness, potentially leading to innovative therapeutic concepts for diverse ailments. Hence, this review analyzes the essential stages in mammalian autophagy, with a specific emphasis on recent research exploring the control of each stage by S1P. Additionally, it sheds light on the roles of S1P-induced autophagy in various disorders.

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Section: Regulation Of Autophagy By S1pmentioning

confidence: 99%

The role of sphingosine-1-phosphate in autophagy and related disorders

Xiao,

Peng,

et al. 2023

Cell Death Discov.

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“…From our vantage point, 20 mg/kg is a very high dose of Dox and single-dose injections cause significant weight loss, mortality, and cardiac atrophy, whereas repetitive injection with a cumulative dose of 15-20 mg/kg also causes atrophy, without significant mortality over the span of 40 days. 4 , 5 It is definitely a strength of the article that the authors did not rely on the high-dose single injection, which probably should not be used on its own as a model of cardiotoxicity.…”

mentioning

confidence: 99%

INKing the Cardiotoxicity Out of Doxorubicin

Guo,

Javaheri

2023

JACC: Basic to Translational Science

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Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length

Glueck,

Lucaciu,

Subburayalu

et al. 2024

Pflugers Arch - Eur J Physiol

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Sphingosine-1-phosphate (S1P) is a bioactive lipid signaling molecule with pleiotropic implications by both auto- and paracrine signaling. Signaling occurs by engaging five G protein-coupled receptors (S1P1-5) or intracellular pathways. While the extensively studied S1P with a chain length of 18 carbon atoms (d18:1 S1P) affects lymphocyte trafficking, immune cell survival and inflammatory responses, the biological implication of atypical S1Ps such as d16:1 or d20:1 remains elusive. As S1P lipids have far-reaching implications in health and disease states in mammalian organisms, the previous contrasting results may be attributed to differences in S1P’s alkyl chain length. Current research is beginning to appreciate these less abundant atypical S1P moieties. This review provides an up-to-date foundation of recent findings on the biological implications of atypical S1P chain lengths and offers a perspective on future research endeavors on S1P alkyl chain length–influenced signaling and its implications for drug discovery.

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Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

Cited by 16 publications

References 56 publications

The role of sphingosine-1-phosphate in autophagy and related disorders

The role of sphingosine-1-phosphate in autophagy and related disorders

INKing the Cardiotoxicity Out of Doxorubicin

Atypical sphingosine-1-phosphate metabolites—biological implications of alkyl chain length

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