Apolipoproteins and metabolism in atherosclerosis

Gotto, Antonio M.

doi:10.1007/978-94-009-0731-7_14

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…The most commonly identified risk predictors were age, family history of diabetes, body mass index, abdominal obesity, hypertension, sex, fasting glucose level, physical inactivity and high density lipoprotein-cholesterol (HDL-C) [ 4 ]. Apolipoprotein A1(ApoA1) and apolipoprotein B (ApoB) are the major parts of the protein moieties of HDL and low density lipoprotein-cholesterol (LDL-C), respectively [ 5 ]. High concentrations of ApoA1 were found to be predictive of type-2 diabetes in Turkish adults [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The association between the apolipoprotein A1/ high density lipoprotein -cholesterol and diabetes in Taiwan — a cross-sectional study

Jian

Lung

et al. 2013

BMC Endocr Disord

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BackgroundTraditional lipid indices have been associated with type 2 diabetes, but it remains uncertain which lipid index is the best discriminator for diabetes. In this study, we aimed to assess lipoproteins, traditional lipid variables, and other variables to discover their association with diabetes in the Taiwanese population.MethodsData from a nationwide cross-sectional population-based survey of 3087 men and 3373 women in 2002 were analyzed in this study. All participants were assessed for anthropometry, glycosylated hemoglobin, fasting sugar and lipid profiles with triglycerides, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and apolipoprotein A1 (ApoA1) and B (ApoB). The ratio of LDL-C/HDL-C, ApoB/ApoA1, ApoB/LDL-C and ApoA1/HDL-C and other variables were analyzed to determine their potential roles in type 2 diabetes in the Taiwanese population. The Odds ratios (ORs) of the risk variables for diabetes were estimated using logistic regression and were adjusted for confounding factors.ResultsThe increased ratio of ApoA1/HDL-C was significantly associated with diabetes in men (top tertile vs. lowest: OR 2.98; 95% CI: 1.12 - 7.92; P-trend = 0.030) and women (top tertile vs. lowest: OR 2.15; 95% CI: 1.00 - 4.59; P-trend = 0.047). A modest increased diabetic risk was evident with ApoB/LDL-C in women (top tertile vs. lowest: OR 2.03; 95% CI: 1.07- 3.85; P-trend = 0.028), but not in men (top tertile v. lowest: OR 1.69; 95% CI: 0.79- 3.62; P-trend = 0.198).ConclusionsApoA1/HDL-C had a significant linear association with diabetes in both sexes and was superior to other lipid and lipoprotein variables among the general Taiwanese population.

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Section: Introductionmentioning

confidence: 99%

The association between the apolipoprotein A1/ high density lipoprotein -cholesterol and diabetes in Taiwan — a cross-sectional study

Jian

Lung

et al. 2013

BMC Endocr Disord

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“…They verified its usefulness by conducting longterm observational clinical cohort studies and comparing clinical information between adult patients with SLE and mouse atherosclerotic models [4].ApoB and apoA1 are major apolipoproteins involved in lipid transport and the pathogenic processes and complications of atherosclerosis. These are the major protein components in very-low-, intermediate-, and low-density lipoproteins, with one protein per particle, and in high-density lipoprotein particles, respectively [5].…”

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confidence: 99%

“…ApoB and apoA1 are major apolipoproteins involved in lipid transport and the pathogenic processes and complications of atherosclerosis. These are the major protein components in very-low-, intermediate-, and low-density lipoproteins, with one protein per particle, and in high-density lipoprotein particles, respectively [5].…”

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confidence: 99%

How to predict the prognosis in juvenile-onset SLE?

Yamamoto

2021

eBioMedicine

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Systemic lupus erythematosus (SLE) is a heterogeneous chronic autoimmune inflammatory disorder that results from widespread immune complex deposition and secondary tissue injury, but its pathogenesis is complex [1]. Juvenile-onset SLE (JSLE), which develops before the age of 18 years and accounts for approximately 20% of all SLE cases, tends to have high disease activities with higher morbidity and mortality rates and require long-term immunosuppressive medications as compared with adult-onset SLE [2]. The main causes of death are renal dysfunction, malignant diseases, and cardiovascular disease (CVD). Owing to the recent improvement in its treatment, fulminant SLE incidence has been decreasing, and premature atherosclerosis greatly influences its mortality. However, to my knowledge, no guidelines have been established for monitoring or managing CVD in patients with SLE or JSLE. Patients at high risk of CVD must be identified, as not all patients with SLE have an equal risk of CVD.Considering the future CVD risk in patients with JSLE and less traditional risk factors, clinicians should use a biomarker or biomarker panel that could easily identify patients. Some clinical studies reported several risk factors of CVD events, such as older age, male sex, dyslipidaemia, hypertension, renal disease, metabolic syndrome, disease duration, and high disease activity, which could be divided into traditional and SLE-specific factors [3]. In this issue of EBioMedicine, Robinson and co-workers identified a novel risk marker, apolipoprotein B (apoB)-to-apoA1 ratio, from an investigation integrating metabolomics, transcriptome, immune profiles, and clinical data of patients with JSLE. They verified its usefulness by conducting longterm observational clinical cohort studies and comparing clinical information between adult patients with SLE and mouse atherosclerotic models [4].ApoB and apoA1 are major apolipoproteins involved in lipid transport and the pathogenic processes and complications of atherosclerosis. These are the major protein components in very-low-, intermediate-, and low-density lipoproteins, with one protein per particle, and in high-density lipoprotein particles, respectively [5].

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“…Apo V é produzida pelo fígado e afeta profundamente as concentrações de triglicerídeos. É um potente ativador da lipólise mediada pela LPL e inibe a produção hepática de VLDL (Gotto, 1990;Mahley et al, 2010).…”

Section: Figura 1 -Representação Esquemática Das Lipoproteínas Ldl E unclassified

Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário

Muramoto¹

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Apolipoproteins and metabolism in atherosclerosis

Cited by 4 publications

References 19 publications

The association between the apolipoprotein A1/ high density lipoprotein -cholesterol and diabetes in Taiwan — a cross-sectional study

The association between the apolipoprotein A1/ high density lipoprotein -cholesterol and diabetes in Taiwan — a cross-sectional study

How to predict the prognosis in juvenile-onset SLE?

Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário

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